SitesBLAST
Comparing YP_002827141.1 NCBI__GCF_000018545.1:YP_002827141.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6laaA Crystal structure of full-length cyp116b46 from tepidiphilus thermophilus (see paper)
27% identity, 84% coverage: 55:362/368 of query aligns to 470:746/753 of 6laaA
- binding fe2/s2 (inorganic) cluster: S700 (≠ A316), C702 (= C318), E703 (= E319), G705 (= G321), C707 (= C323), G708 (= G324), C710 (= C326), C740 (= C356)
- binding flavin mononucleotide: R487 (= R74), Q488 (≠ T75), Y489 (= Y76), S490 (≠ T77), Q506 (≠ K93), S511 (= S98), R512 (≠ I99), G514 (vs. gap), S515 (≠ T101), I553 (≠ S140), E651 (≠ G252), F653 (≠ Y254)
Sites not aligning to the query:
- active site: 177, 251, 252, 359, 360, 361
- binding carbonate ion: 90, 91, 92, 241
- binding protoporphyrin ix containing fe: 54, 91, 92, 99, 103, 249, 252, 253, 298, 351, 352, 353, 357, 359, 361
3ozwA The crystal structure of flavohemoglobin from r. Eutrophus in complex with ketoconazole (see paper)
30% identity, 60% coverage: 48:266/368 of query aligns to 178:403/403 of 3ozwA
- binding flavin-adenine dinucleotide: R206 (= R74), Q207 (≠ T75), Y208 (= Y76), S209 (≠ T77), S222 (≠ A89), V223 (≠ I90), K224 (≠ T91), E226 (≠ K93), P232 (= P96), G234 (≠ S98), Y235 (≠ I99), V236 (≠ G100), S237 (≠ T101), V276 (≠ S140), T279 (= T143), V395 (≠ S258), F396 (= F259)
- binding 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine: P398 (≠ A261)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 46, 50
- binding protoporphyrin ix containing fe: 42, 43, 81, 85, 88, 90, 94, 95, 98, 126, 130, 133
- binding 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine: 53, 56, 102
3ozvA The crystal structure of flavohemoglobin from r. Eutrophus in complex with econazole (see paper)
30% identity, 60% coverage: 48:266/368 of query aligns to 178:403/403 of 3ozvA
- binding flavin-adenine dinucleotide: R206 (= R74), Q207 (≠ T75), Y208 (= Y76), S209 (≠ T77), S222 (≠ A89), V223 (≠ I90), K224 (≠ T91), E226 (≠ K93), P232 (= P96), G234 (≠ S98), Y235 (≠ I99), V236 (≠ G100), S237 (≠ T101), V276 (≠ S140), T279 (= T143), F396 (= F259)
Sites not aligning to the query:
- binding 1-[(2s)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole: 24, 28, 57, 102, 106
- binding flavin-adenine dinucleotide: 44, 46, 48
- binding protoporphyrin ix containing fe: 43, 81, 84, 85, 88, 90, 94, 95, 98, 126, 130, 133
3ozuA The crystal structure of flavohemoglobin from r. Eutrophus in complex with miconazole (see paper)
30% identity, 60% coverage: 48:266/368 of query aligns to 178:403/403 of 3ozuA
- binding flavin-adenine dinucleotide: R206 (= R74), Q207 (≠ T75), Y208 (= Y76), S209 (≠ T77), S222 (≠ A89), V223 (≠ I90), K224 (≠ T91), E226 (≠ K93), P232 (= P96), G234 (≠ S98), Y235 (≠ I99), V236 (≠ G100), S237 (≠ T101), E394 (= E257), V395 (≠ S258), G397 (= G260), P398 (≠ A261)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 46, 47
- binding protoporphyrin ix containing fe: 43, 44, 81, 85, 88, 90, 94, 95, 98, 126, 129, 130, 133
- binding 1-[(2R)-2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole: 25, 28, 43, 56, 57, 102, 122, 125, 126
P39662 Flavohemoprotein; FHP; Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD; EC 1.14.12.17 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
30% identity, 60% coverage: 48:266/368 of query aligns to 178:403/403 of P39662
Sites not aligning to the query:
- 60 A→Y: Does not affect phospholipid-binding.
- 98 V→F: Blocks phospholipid-binding.
1cqxA Crystal structure of the flavohemoglobin from alcaligenes eutrophus at 1.75 a resolution (see paper)
30% identity, 60% coverage: 48:266/368 of query aligns to 178:403/403 of 1cqxA
- binding flavin-adenine dinucleotide: Y190 (≠ F60), R206 (= R74), Q207 (≠ T75), Y208 (= Y76), S209 (≠ T77), S222 (≠ A89), E226 (≠ K93), Q231 (= Q95), P232 (= P96), G234 (≠ S98), Y235 (≠ I99), V236 (≠ G100), S237 (≠ T101), V395 (≠ S258), G397 (= G260), P398 (≠ A261)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 46, 47
- binding protoporphyrin ix containing fe: 43, 44, 81, 85, 88, 90, 94, 95, 98, 126, 129, 130, 133
6kbhA Crystal structure of an intact type iv self-sufficient cytochrome p450 monooxygenase
26% identity, 79% coverage: 70:359/368 of query aligns to 495:755/765 of 6kbhA
- binding fe2/s2 (inorganic) cluster: C714 (= C318), E715 (= E319), G717 (= G321), C719 (= C323), G720 (= G324), C722 (= C326), C752 (= C356)
- binding flavin mononucleotide: R499 (= R74), Q500 (≠ T75), Y501 (= Y76), S502 (≠ T77), A516 (≠ T91), L518 (vs. gap), S523 (≠ T97), R524 (≠ S98), G526 (= G100), S527 (≠ T101), I565 (≠ S140), T568 (= T143), E663 (= E257), F665 (= F259), I718 (= I322)
Sites not aligning to the query:
- active site: 190, 264, 265, 372, 373, 374
- binding protoporphyrin ix containing fe: 67, 104, 105, 112, 116, 261, 262, 265, 266, 308, 311, 313, 364, 365, 370, 372, 373, 374, 378
2piaA Phthalate dioxygenase reductase: a modular structure for electron transfer from pyridine nucleotides to [2fe-2s] (see paper)
27% identity, 78% coverage: 74:359/368 of query aligns to 55:311/321 of 2piaA
- binding fe2/s2 (inorganic) cluster: S270 (≠ A316), C272 (= C318), E273 (= E319), G275 (= G321), C277 (= C323), G278 (= G324), C280 (= C326), C308 (= C356)
- binding flavin mononucleotide: R55 (= R74), T56 (= T75), Y57 (= Y76), S58 (≠ T77), A72 (≠ T91), V73 (≠ I92), G79 (≠ S98), R80 (≠ I99), G82 (≠ T101), S83 (≠ R102), I121 (≠ S140), T124 (= T143), E223 (= E257), F225 (= F259)
Sites not aligning to the query:
P33164 Phthalate dioxygenase reductase; PDR; EC 1.-.-.- from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
27% identity, 78% coverage: 74:359/368 of query aligns to 56:312/322 of P33164
- RT 56:57 (= RT 74:75) binding FMN
- AVK 73:75 (≠ TIK 91:93) binding FMN
- RGGS 81:84 (≠ IGTR 99:102) binding FMN
- T125 (= T143) binding FMN
- F226 (= F259) binding FMN
- C273 (= C318) binding [2Fe-2S] cluster
- S275 (= S320) binding FMN
- C278 (= C323) binding [2Fe-2S] cluster
- C281 (= C326) binding [2Fe-2S] cluster
- C309 (= C356) binding [2Fe-2S] cluster
4eh1A Crystal structure of the flavohem-like-fad/NAD binding domain of nitric oxide dioxygenase from vibrio cholerae o1 biovar el tor
27% identity, 61% coverage: 36:260/368 of query aligns to 14:236/237 of 4eh1A
- binding flavin-adenine dinucleotide: Y39 (≠ F60), R55 (= R74), Q56 (≠ T75), Y57 (= Y76), S58 (≠ T77), S71 (≠ A89), V72 (≠ I90), E75 (vs. gap), N81 (≠ P96), G83 (≠ S98), L84 (≠ I99), V85 (≠ G100), S86 (≠ T101), T127 (= T143), E233 (= E257), F235 (= F259)
1gvhA The x-ray structure of ferric escherichia coli flavohemoglobin reveals an unespected geometry of the distal heme pocket (see paper)
26% identity, 58% coverage: 47:260/368 of query aligns to 175:391/396 of 1gvhA
- binding flavin-adenine dinucleotide: Y188 (≠ F60), R204 (= R74), Q205 (≠ T75), Y206 (= Y76), S207 (≠ T77), A220 (= A89), V221 (≠ I90), E224 (≠ Q95), G227 (≠ S98), Q228 (≠ I99), V229 (≠ G100), S230 (≠ T101), V269 (≠ S140), T272 (= T143), E388 (= E257), F390 (= F259)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 46, 48, 50
- binding protoporphyrin ix containing fe: 43, 53, 56, 57, 60, 61, 81, 84, 85, 90, 94, 95, 127, 131, 393
P24232 Flavohemoprotein; Flavohemoglobin; HMP; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD; EC 1.14.12.17 from Escherichia coli (strain K12) (see 2 papers)
26% identity, 58% coverage: 47:260/368 of query aligns to 175:391/396 of P24232
Sites not aligning to the query:
- 29 mutation Y->E,H: 15 to 35-fold reduction in NO dioxygenase activity.; Y→F: 30-fold reduction in NO dioxygenase activity, and 80-fold increase in the O(2) dissociation rate constant.
- 95 active site, Charge relay system
- 135 active site, Charge relay system
1tvcA Fad and nadh binding domain of methane monooxygenase reductase from methylococcus capsulatus (bath) (see paper)
26% identity, 56% coverage: 54:259/368 of query aligns to 43:244/250 of 1tvcA
- active site: Y63 (= Y76), S64 (≠ T77), L215 (≠ C230)
- binding dihydroflavine-adenine dinucleotide: F49 (= F60), R61 (= R74), S62 (≠ T75), Y63 (= Y76), S64 (≠ T77), L78 (≠ T91), I79 (= I92), R80 (≠ K93), L82 (≠ Q95), F87 (≠ G100), G128 (= G141), N155 (≠ A167), E159 (= E172), S186 (vs. gap), G187 (vs. gap), E242 (= E257), F244 (= F259)
Sites not aligning to the query:
1krhA X-ray structure of benzoate dioxygenase reductase (see paper)
23% identity, 60% coverage: 42:262/368 of query aligns to 122:337/337 of 1krhA
- active site: C306 (= C231)
- binding flavin-adenine dinucleotide: Y143 (≠ F60), R155 (= R74), S156 (≠ T75), Y157 (= Y76), S158 (≠ T77), V171 (≠ T91), V172 (≠ I92), G178 (≠ S98), K179 (≠ I99), M180 (≠ G100), S181 (≠ T101), T219 (≠ S140), E332 (= E257), F334 (= F259), S335 (≠ G260), A336 (= A261), N337 (≠ T262)
Sites not aligning to the query:
2eixA The structure of physarum polycephalum cytochrome b5 reductase (see paper)
23% identity, 52% coverage: 58:249/368 of query aligns to 45:235/243 of 2eixA
- active site: H47 (≠ F60), Y63 (= Y76), T64 (= T77), C217 (= C231)
- binding flavin-adenine dinucleotide: R61 (= R74), P62 (≠ T75), Y63 (= Y76), T64 (= T77), I78 (≠ T91), Y82 (≠ Q95), K84 (≠ T97), G85 (≠ S98), M87 (≠ G100), S88 (≠ T101), T126 (≠ S140), T129 (= T143), F195 (≠ R210), M221 (≠ P235), A225 (= A239)
P0DPQ8 Aromatic O-demethylase, reductase subunit; NADH--hemoprotein reductase; EC 1.6.2.- from Amycolatopsis sp. (strain ATCC 39116 / 75iv2) (see paper)
42% identity, 20% coverage: 297:368/368 of query aligns to 14:87/334 of P0DPQ8
- C35 (= C318) binding [2Fe-2S] cluster
- C40 (= C323) binding [2Fe-2S] cluster
- C43 (= C326) binding [2Fe-2S] cluster
- C75 (= C356) binding [2Fe-2S] cluster
Sites not aligning to the query:
- 145:148 binding FAD
- 162:164 binding FAD
- 170:172 binding FAD
- 215 binding FAD
- 330 binding FAD
- 334 binding FAD
5ogxA Crystal structure of amycolatopsis cytochrome p450 reductase gcob. (see paper)
42% identity, 20% coverage: 297:368/368 of query aligns to 13:86/333 of 5ogxA
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 132, 144, 145, 146, 147, 161, 162, 165, 168, 169, 170, 171, 214, 329, 331, 333
7ylrA Structure of a bacteria protein
26% identity, 74% coverage: 86:357/368 of query aligns to 76:314/326 of 7ylrA
- binding fe2/s2 (inorganic) cluster: C276 (= C318), K277 (≠ E319), G279 (= G321), C281 (= C323), G282 (= G324), C284 (= C326), C314 (= C357)
- binding flavin mononucleotide: A79 (= A89), V80 (≠ I90), R81 (≠ T91), G86 (≠ P96), R87 (≠ T97), G89 (= G100), S90 (≠ T101), T131 (= T143), E229 (= E257), F231 (= F259), E233 (= E274), R278 (≠ S320)
Sites not aligning to the query:
4fxcA Tertiary structure of [2fe-2s] ferredoxin from spirulina platensis refined at 2.5 angstroms resolution: structural comparisons of plant- type ferredoxins and an electrostatic potential analysis (see paper)
36% identity, 21% coverage: 290:367/368 of query aligns to 13:90/98 of 4fxcA
7c3bC Ferredoxin reductase in carbazole 1,9a-dioxygenase (fad apo form) (see paper)
24% identity, 56% coverage: 54:259/368 of query aligns to 134:333/334 of 7c3bC
Sites not aligning to the query:
Query Sequence
>YP_002827141.1 NCBI__GCF_000018545.1:YP_002827141.1
MTMMLTGTTPTPLPLDQMKPWNSARQMLVCTSVTDEAPDVKTFTFAVEGGGWFNYMPGQF
ITVELRAKGGDLHRTYTVSSSPSRPYAIAITIKAQPTSIGTRWMFENVRSGSRVRAYGPS
GHFTLSRNPGKKYLFISAGSGITPMMSMLRWLSDCAPDIDVVFINSARRPEEIIFREELE
LLAKRMPNLSLGFLPEARSVASPWAGLMGRIDRHKLSMLTPDFMGREIFCCGPDPFMRAV
SAIVRAEGFDMGHYHQESFGATSIAETVHKQAREIVLDGKPTGVTVSFLGSNEEQVCEPG
KTILETARAAGVRIPAACESGICGTCKVLKRSGEVVMHHNGGISDQEINAGYVLACCSRP
TTPVEIEA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory