SitesBLAST
Comparing YP_004139522.1 NCBI__GCF_000185905.1:YP_004139522.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6d9yB Crystal structure of a short chain dehydrogenase/reductase sdr from burkholderia phymatum with partially occupied NAD
53% identity, 100% coverage: 1:248/248 of query aligns to 2:251/251 of 6d9yB
- active site: G20 (= G19), S145 (= S142), Y158 (= Y155)
- binding nicotinamide-adenine-dinucleotide: G16 (= G15), R19 (≠ Q18), G20 (= G19), D40 (= D39), L41 (= L40), V64 (= V61), D65 (= D62), Q66 (≠ V63), A93 (= A90), S145 (= S142), Y158 (= Y155), K162 (= K159), P188 (= P185), A189 (= A186), A190 (≠ T187), A191 (= A188), T193 (= T190)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
36% identity, 97% coverage: 6:246/248 of query aligns to 3:246/248 of 6ixmC
- active site: G16 (= G19), S142 (= S142), Y155 (= Y155), K159 (= K159)
- binding nicotinamide-adenine-dinucleotide: G12 (= G15), S15 (≠ Q18), G16 (= G19), I17 (≠ L20), D36 (= D39), I37 (≠ L40), A61 (≠ V61), D62 (= D62), T63 (≠ V63), N89 (≠ S89), A90 (= A90), M140 (≠ I140), S142 (= S142), Y155 (= Y155), K159 (= K159), P185 (= P185), A186 (= A186), Y187 (≠ T187), I188 (≠ A188), L192 (≠ I192)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
38% identity, 95% coverage: 11:246/248 of query aligns to 9:247/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G15), S16 (≠ Q18), G17 (= G19), I18 (≠ L20), D37 (= D39), I38 (≠ L40), A62 (≠ V61), D63 (= D62), S64 (≠ V63), N90 (≠ S89), M141 (≠ I140), Y156 (= Y155), K160 (= K159), P186 (= P185), G187 (≠ A186), Y188 (≠ T187), I189 (≠ A188), L193 (≠ I192)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
35% identity, 96% coverage: 6:244/248 of query aligns to 5:241/244 of 4nbuB
- active site: G18 (= G19), N111 (= N114), S139 (= S142), Q149 (≠ A152), Y152 (= Y155), K156 (= K159)
- binding acetoacetyl-coenzyme a: D93 (≠ P95), K98 (≠ V101), S139 (= S142), N146 (= N149), V147 (≠ P150), Q149 (≠ A152), Y152 (= Y155), F184 (≠ T187), M189 (≠ I192), K200 (≠ Y203)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G15), N17 (≠ Q18), G18 (= G19), I19 (≠ L20), D38 (= D39), F39 (≠ L40), V59 (= V61), D60 (= D62), V61 (= V63), N87 (≠ S89), A88 (= A90), G89 (= G91), I90 (= I92), T137 (≠ I140), S139 (= S142), Y152 (= Y155), K156 (= K159), P182 (= P185), F184 (≠ T187), T185 (≠ A188), T187 (= T190), M189 (≠ I192)
2rh4A Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
37% identity, 98% coverage: 7:248/248 of query aligns to 1:257/257 of 2rh4A
- active site: G13 (= G19), N110 (= N114), S140 (= S142), Y153 (= Y155), K157 (= K159), Y198 (vs. gap)
- binding 3-methyl-1,6,8-trihydroxyanthraquinone: T141 (≠ V143), Q145 (≠ E147), V147 (≠ N149), Y153 (= Y155), F185 (≠ T187), L254 (≠ R245)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G9 (= G15), T11 (≠ A17), S12 (≠ Q18), G13 (= G19), I14 (≠ L20), A33 (≠ D39), R34 (≠ L40), G35 (≠ D41), C58 (≠ V61), D59 (= D62), V60 (= V63), N86 (≠ S89), G88 (= G91), S140 (= S142), Y153 (= Y155), K157 (= K159), P183 (= P185), G184 (≠ A186), V186 (≠ A188), T188 (= T190), M190 (vs. gap)
P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
37% identity, 98% coverage: 7:248/248 of query aligns to 5:261/261 of P16544
- 11:39 (vs. 13:41, 34% identical) binding NADP(+)
- D63 (= D62) binding NADP(+)
- K161 (= K159) binding NADP(+)
1w4zA Structure of actinorhodin polyketide (actiii) reductase (see paper)
37% identity, 98% coverage: 7:248/248 of query aligns to 3:259/259 of 1w4zA
- active site: G15 (= G19), N112 (= N114), S142 (= S142), Y155 (= Y155), K159 (= K159), Y200 (vs. gap)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G15), T13 (≠ A17), S14 (≠ Q18), G15 (= G19), I16 (≠ L20), R36 (≠ L40), G37 (≠ D41), D61 (= D62), V62 (= V63), N88 (≠ S89), G90 (= G91), S142 (= S142), Y155 (= Y155), K159 (= K159), P185 (= P185), G186 (≠ A186), V188 (≠ A188), T190 (= T190)
2rh4B Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
37% identity, 98% coverage: 7:248/248 of query aligns to 12:268/268 of 2rh4B
- active site: G24 (= G19), N121 (= N114), S151 (= S142), Y164 (= Y155), K168 (= K159), Y209 (vs. gap)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G20 (= G15), T22 (≠ A17), S23 (≠ Q18), I25 (≠ L20), A44 (≠ D39), R45 (≠ L40), G46 (≠ D41), C69 (≠ V61), D70 (= D62), V71 (= V63), N97 (≠ S89), S151 (= S142), Y164 (= Y155), K168 (= K159), G195 (≠ A186), V197 (≠ A188), T199 (= T190), M201 (vs. gap)
1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound (see paper)
37% identity, 96% coverage: 11:248/248 of query aligns to 4:256/256 of 1xr3A
- active site: G12 (= G19), N109 (= N114), S139 (= S142), Y152 (= Y155), K156 (= K159), Y197 (vs. gap)
- binding 4-(diazenylcarbonyl)pyridine: T140 (≠ V143), G141 (≠ A144), V146 (≠ N149)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G15), T10 (≠ A17), S11 (≠ Q18), G12 (= G19), I13 (≠ L20), A32 (≠ D39), R33 (≠ L40), G34 (≠ D41), C57 (≠ V61), D58 (= D62), V59 (= V63), N85 (≠ S89), A86 (= A90), G87 (= G91), S139 (= S142), Y152 (= Y155), K156 (= K159), G183 (≠ A186), V185 (≠ A188), T187 (= T190), P188 (≠ R191)
7pcsB Structure of the heterotetrameric sdr family member bbscd (see paper)
35% identity, 96% coverage: 11:248/248 of query aligns to 7:245/247 of 7pcsB
- binding nicotinamide-adenine-dinucleotide: G11 (= G15), M16 (≠ L20), D35 (= D39), I36 (≠ L40), I62 (≠ V63), N88 (≠ S89), G90 (= G91), I138 (= I140), S140 (= S142), Y152 (= Y155), K156 (= K159), I185 (≠ A188)
5u9pB Crystal structure of a gluconate 5-dehydrogenase from burkholderia cenocepacia j2315 in complex with NADP and tartrate
34% identity, 100% coverage: 1:247/248 of query aligns to 9:259/261 of 5u9pB
- active site: G27 (= G19), S152 (= S142), Y165 (= Y155), K169 (= K159)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G23 (= G15), R26 (≠ Q18), G27 (= G19), I28 (≠ L20), R48 (≠ L40), D73 (= D62), V74 (= V63), N100 (≠ S89), A101 (= A90), I150 (= I140), Y165 (= Y155), K169 (= K159), P195 (= P185), F198 (≠ A188), T200 (= T190), L202 (≠ I192), N203 (≠ L193)
Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
35% identity, 96% coverage: 11:248/248 of query aligns to 8:246/248 of Q9KJF1
- S15 (≠ Q18) binding NAD(+)
- D36 (= D39) binding NAD(+)
- D62 (= D62) binding NAD(+)
- I63 (≠ V63) binding NAD(+)
- N89 (≠ S89) binding NAD(+)
- Y153 (= Y155) binding NAD(+)
- K157 (= K159) binding NAD(+)
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
5ts3A Crystal structure of a 3-oxoacyl-[acyl-carrier protein] reductase with bound NAD from brucella melitensis
38% identity, 95% coverage: 9:244/248 of query aligns to 20:261/265 of 5ts3A
- active site: G30 (= G19), S158 (= S142), V168 (≠ N151), Y172 (= Y155), K176 (= K159)
- binding nicotinamide-adenine-dinucleotide: G26 (= G15), R29 (≠ Q18), G30 (= G19), I31 (≠ L20), D50 (= D39), L51 (= L40), D77 (= D65), V78 (≠ W66), N101 (≠ S89), V129 (= V113), T156 (≠ I140), Y172 (= Y155), K176 (= K159), P202 (= P185), I205 (≠ A188), T207 (= T190)
3ak4A Crystal structure of nadh-dependent quinuclidinone reductase from agrobacterium tumefaciens
37% identity, 97% coverage: 4:244/248 of query aligns to 3:254/258 of 3ak4A
- active site: G18 (= G19), S141 (= S142), L151 (≠ A152), Y154 (= Y155), K158 (= K159), E199 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: K17 (≠ Q18), G18 (= G19), I19 (≠ L20), D38 (= D39), L39 (= L40), V60 (= V61), D61 (= D62), V62 (= V63), N88 (≠ S89), A89 (= A90), G90 (= G91), T139 (≠ I140), S141 (= S142), Y154 (= Y155), K158 (= K159), G185 (≠ A186), V187 (≠ A188), T189 (= T190), M191 (≠ I192)
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
34% identity, 96% coverage: 6:244/248 of query aligns to 2:239/243 of 7emgB
5vmlA Crystal structure of acetoacetyl-coa reductase from burkholderia pseudomallei 1710b with bound NADP
35% identity, 94% coverage: 11:244/248 of query aligns to 5:241/245 of 5vmlA
- active site: G13 (= G19), N111 (= N114), S139 (= S142), Y152 (= Y155), K156 (= K159)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G9 (= G15), G12 (≠ Q18), G13 (= G19), I14 (≠ L20), C33 (≠ V35), G34 (≠ S36), R39 (≠ D41), G59 (≠ V61), N60 (≠ D62), V61 (= V63), N87 (≠ S89), G89 (= G91), I90 (= I92), S139 (= S142), Y152 (= Y155), K156 (= K159), P182 (= P185), G183 (≠ A186), I185 (≠ A188)
9febA Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae in complex with NADP
36% identity, 98% coverage: 1:244/248 of query aligns to 1:256/261 of 9febA
9fe6B Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae
36% identity, 98% coverage: 1:244/248 of query aligns to 1:256/261 of 9fe6B
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
34% identity, 97% coverage: 4:244/248 of query aligns to 1:240/244 of 6t77A
- active site: G16 (= G19), S138 (= S142), Y151 (= Y155)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G15), S14 (≠ A17), R15 (≠ Q18), T37 (≠ L40), L58 (≠ V61), N59 (≠ D62), V60 (= V63), A87 (= A90), G88 (= G91), I89 (= I92)
1zemA Crystal structure of NAD+-bound xylitol dehydrogenase (see paper)
33% identity, 96% coverage: 6:244/248 of query aligns to 3:260/260 of 1zemA
- active site: N16 (≠ G19), S142 (= S142), Y155 (= Y155), K159 (= K159), D212 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: G12 (= G15), G15 (≠ Q18), N16 (≠ G19), I17 (≠ L20), D36 (= D39), M37 (≠ L40), D62 (= D62), V63 (= V63), N89 (≠ S89), A90 (= A90), G91 (= G91), T140 (≠ I140), S142 (= S142), Y155 (= Y155), K159 (= K159), P185 (= P185), M188 (≠ A188)
Query Sequence
>YP_004139522.1 NCBI__GCF_000185905.1:YP_004139522.1
MNRIDLDGQHAVVTGGAQGLGFAMARRFVASGATVSLWDLDEARLETAKKELGNAATTEI
VDVADWTSVDAARARTEDLAGKISILVNSAGIAGPAAPLDVYDIETWKKVIDVNVNGTFY
VNRAVVPGMKERNYGRIVNIASVAGKEGNPNASAYSASKAAVIGLTKSLGKELAQYDIAV
NCISPATAQTRILEQLTPEHIEYMRSRIPRGRLLEVDEAAAMVAWLVSKENSFTTASTFD
LSGGRTTY
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory