SitesBLAST
Comparing YP_004141818.1 NCBI__GCF_000185905.1:YP_004141818.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
56% identity, 99% coverage: 4:495/496 of query aligns to 2:494/495 of 5iuwA
- active site: N166 (= N168), K189 (= K191), E265 (= E267), C300 (= C302), E399 (= E400), D476 (= D477)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), M170 (≠ D172), C300 (= C302), D457 (= D458), F465 (= F466)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), T241 (= T243), G242 (= G244), S243 (= S245), I246 (≠ V248), Y253 (= Y255), E265 (= E267), A266 (≠ T268), C300 (= C302), E399 (= E400), F401 (= F402)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
56% identity, 99% coverage: 4:495/496 of query aligns to 2:494/495 of 5iuvA
- active site: N166 (= N168), K189 (= K191), E265 (= E267), C300 (= C302), E399 (= E400), D476 (= D477)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), S191 (≠ A193), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), T241 (= T243), G242 (= G244), S243 (= S245), I246 (≠ V248), Y253 (= Y255), E265 (= E267), A266 (≠ T268), C300 (= C302), E399 (= E400), F401 (= F402)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
56% identity, 99% coverage: 4:495/496 of query aligns to 2:494/495 of 7jsoA
- active site: N166 (= N168), E265 (= E267), A300 (≠ C302), D476 (= D477)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), W174 (= W176), V299 (= V301), A300 (≠ C302), T301 (≠ S303), D457 (= D458), F465 (= F466)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), K189 (= K191), E192 (= E194), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), G242 (= G244), S243 (= S245), I246 (≠ V248), A266 (≠ T268), G267 (= G269), A300 (≠ C302), E399 (= E400), F401 (= F402)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
50% identity, 100% coverage: 1:494/496 of query aligns to 1:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V164), L166 (≠ V165), P167 (= P166), W168 (= W167), K192 (= K191), G225 (= G224), G229 (= G228), F243 (= F242), G245 (= G244), S246 (= S245), T249 (≠ V248), L252 (≠ M251), F253 (= F252), Y256 (= Y255), C269 (≠ T268), G270 (= G269), C303 (= C302), H350 (= H349), K353 (≠ N352), F400 (= F402)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
45% identity, 96% coverage: 16:491/496 of query aligns to 3:475/486 of 4pxlA
- active site: N154 (= N168), K177 (= K191), E253 (= E267), C287 (= C302), E384 (= E400), D461 (= D477)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ V164), V151 (= V165), P152 (= P166), W153 (= W167), K177 (= K191), E180 (= E194), G210 (= G224), G214 (= G228), A215 (≠ Q229), F228 (= F242), G230 (= G244), S231 (= S245), V234 (= V248), E253 (= E267), G255 (= G269), C287 (= C302), Q334 (≠ H349), K337 (≠ N352), E384 (= E400), F386 (= F402)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
44% identity, 96% coverage: 21:494/496 of query aligns to 18:488/491 of 5gtlA
- active site: N165 (= N168), K188 (= K191), E263 (= E267), C297 (= C302), E394 (= E400), E471 (≠ D477)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V164), P163 (= P166), K188 (= K191), A190 (= A193), E191 (= E194), Q192 (= Q195), G221 (= G224), G225 (= G228), G241 (= G244), S242 (= S245), T245 (≠ V248), L264 (≠ T268), C297 (= C302), E394 (= E400), F396 (= F402)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
44% identity, 96% coverage: 21:494/496 of query aligns to 18:488/491 of 5gtkA
- active site: N165 (= N168), K188 (= K191), E263 (= E267), C297 (= C302), E394 (= E400), E471 (≠ D477)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V164), I162 (≠ V165), P163 (= P166), W164 (= W167), K188 (= K191), E191 (= E194), G221 (= G224), G225 (= G228), A226 (≠ Q229), F239 (= F242), G241 (= G244), S242 (= S245), T245 (≠ V248), Y248 (≠ M251), L264 (≠ T268), C297 (= C302), Q344 (≠ H349), R347 (≠ N352), E394 (= E400), F396 (= F402)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
44% identity, 97% coverage: 12:491/496 of query aligns to 13:490/501 of Q56YU0
- G152 (vs. gap) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A417) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
47% identity, 96% coverage: 16:492/496 of query aligns to 8:484/494 of 4pz2B
- active site: N159 (= N168), K182 (= K191), E258 (= E267), C292 (= C302), E392 (= E400), D469 (= D477)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V164), I156 (≠ V165), P157 (= P166), W158 (= W167), N159 (= N168), M164 (= M173), K182 (= K191), A184 (= A193), E185 (= E194), G215 (= G224), G219 (= G228), F233 (= F242), T234 (= T243), G235 (= G244), S236 (= S245), V239 (= V248), E258 (= E267), L259 (≠ T268), C292 (= C302), E392 (= E400), F394 (= F402)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
44% identity, 97% coverage: 17:495/496 of query aligns to 1:478/489 of 4o6rA
- active site: N150 (= N168), K173 (= K191), E248 (= E267), C282 (= C302), E383 (= E400), E460 (≠ D477)
- binding adenosine monophosphate: I146 (≠ V164), V147 (= V165), K173 (= K191), G206 (= G224), G210 (= G228), Q211 (= Q229), F224 (= F242), G226 (= G244), S227 (= S245), T230 (≠ V248), R233 (≠ M251)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 5l13A
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F169), M168 (= M173), W171 (= W176), F290 (= F296), C295 (≠ V301), C296 (= C302), C297 (≠ S303), D451 (= D458), F453 (≠ L460)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 4kwgA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F169), M168 (= M173), C295 (≠ V301), C296 (= C302), C297 (≠ S303), D451 (= D458), F453 (≠ L460)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 4kwfA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F169), M168 (= M173), W171 (= W176), E262 (= E267), C295 (≠ V301), C296 (= C302), C297 (≠ S303), D451 (= D458), F453 (≠ L460), F459 (= F466)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 3sz9A
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F169), C295 (≠ V301), C296 (= C302), D451 (= D458), F453 (≠ L460), F459 (= F466)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 3injA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ G123), F164 (= F169), L167 (≠ D172), F286 (= F292), F290 (= F296), D451 (= D458), F453 (≠ L460)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 2vleA
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding daidzin: M118 (≠ G123), F164 (= F169), M168 (= M173), W171 (= W176), F286 (= F292), F290 (= F296), C295 (≠ V301), C296 (= C302), D451 (= D458), V452 (≠ A459), F453 (≠ L460)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 1o01B
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding (2e)-but-2-enal: C296 (= C302), C297 (≠ S303), F453 (≠ L460)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V164), I160 (≠ V165), P161 (= P166), W162 (= W167), K186 (= K191), E189 (= E194), G219 (= G224), G223 (= G228), A224 (≠ Q229), F237 (= F242), G239 (= G244), S240 (= S245), I243 (≠ V248), L263 (≠ T268), G264 (= G269), C296 (= C302), Q343 (≠ H349), E393 (= E400), F395 (= F402)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 12:488/494 of 1cw3A
- active site: N163 (= N168), K186 (= K191), E262 (= E267), C296 (= C302), E393 (= E400), E470 (≠ D477)
- binding magnesium ion: V34 (= V40), D103 (= D108), Q190 (= Q195)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V164), I160 (≠ V165), P161 (= P166), W162 (= W167), K186 (= K191), G219 (= G224), G223 (= G228), A224 (≠ Q229), F237 (= F242), G239 (= G244), S240 (= S245), I243 (≠ V248), L263 (≠ T268), G264 (= G269), C296 (= C302), Q343 (≠ H349), K346 (≠ N352), E393 (= E400), F395 (= F402)
P05091 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Homo sapiens (Human) (see 5 papers)
44% identity, 96% coverage: 18:495/496 of query aligns to 35:511/517 of P05091
- E337 (= E320) to V: in dbSNP:rs1062136
- E496 (≠ L480) to K: in allele ALDH2*3; dbSNP:rs769724893
- E504 (≠ A488) to K: in AMEDS; allele ALDH2*2; drastic reduction of enzyme activity; dbSNP:rs671
Sites not aligning to the query:
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 96% coverage: 18:495/496 of query aligns to 11:487/493 of 4fr8A
- active site: N162 (= N168), K185 (= K191), Q261 (≠ E267), C295 (= C302), E392 (= E400), E469 (≠ D477)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ V164), I159 (≠ V165), W161 (= W167), K185 (= K191), G218 (= G224), G222 (= G228), A223 (≠ Q229), F236 (= F242), G238 (= G244), S239 (= S245), I242 (≠ V248), Q342 (≠ H349), K345 (≠ N352), E392 (= E400), F394 (= F402)
- binding propane-1,2,3-triyl trinitrate: F163 (= F169), L166 (≠ D172), W170 (= W176), F289 (= F296), S294 (≠ V301), C295 (= C302), D450 (= D458), F452 (≠ L460)
Query Sequence
>YP_004141818.1 NCBI__GCF_000185905.1:YP_004141818.1
MSELSHKDWIGKASAIRFRDKAFIDGKTVAARSGRTFASVNPATGEVLAEVASCGEEDID
LAVAAARRSFNAGVWSRTSPAHRKEVLLRLAQLLRDNLHELALLESLDMGKLVRDAASVD
VPGSAAIFQWYGEAIDKIYGEVAPTGEGDLVLVRREPLGVVGAVVPWNFPLDMATWKCAP
ALAAGNSVVLKPAEQSPLSALLLAELAMEAGLPAGVLNVVPGLGETAGQALGRHMDVDCL
AFTGSTAVGKMFLQYSGQSNMKQVWLETGGKSPNLVFADCGDLDVVADMAAFGIFFNQGE
VCSANSRLLVQRGIKDALVEKLVQRAAATQPGDPLDPISKMGAMVDSRHAANVMRFVEAG
KKTARLVAGGDMVTVNGRGSFVQPTIFDDVAPADPIARDEIFGPVLSVIAFDDEADAIRI
ANDSPYGLAASLWTDSLSRAHRIAGRLQAGTVSVNTVDALSPMTPFGGFKQSGFGRDLSL
HALDKYTALKTTWIKY
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory