SitesBLAST
Comparing YP_004142091.1 NCBI__GCF_000185905.1:YP_004142091.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
39% identity, 79% coverage: 13:228/273 of query aligns to 2:218/501 of P04983
- K43 (= K54) mutation to R: Loss of transport.
4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
30% identity, 81% coverage: 21:242/273 of query aligns to 7:223/240 of 4ymuJ
- binding adenosine-5'-triphosphate: F11 (= F25), V16 (≠ A30), S36 (≠ N50), G37 (= G51), S38 (≠ A52), G39 (= G53), K40 (= K54), S41 (= S55), T42 (= T56), E162 (= E177), H194 (= H209)
- binding magnesium ion: S41 (= S55), E162 (= E177)
P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
36% identity, 81% coverage: 16:235/273 of query aligns to 4:218/369 of P19566
- L86 (= L101) mutation to F: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- P160 (= P178) mutation to L: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- D165 (≠ G183) mutation to N: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
Sites not aligning to the query:
- 306 E→K: Loss of transport. No effect on ATP-binding and ATP hydrolysis. Retains repressor activity.
2awnB Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
35% identity, 81% coverage: 16:235/273 of query aligns to 3:217/374 of 2awnB
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state (see paper)
35% identity, 81% coverage: 16:235/273 of query aligns to 3:217/371 of 3puyA
- binding phosphoaminophosphonic acid-adenylate ester: W12 (≠ F25), S37 (≠ N50), G38 (= G51), C39 (≠ A52), G40 (= G53), K41 (= K54), S42 (= S55), T43 (= T56), Q81 (= Q97), R128 (= R141), A132 (≠ S151), S134 (= S153), G136 (= G155), Q137 (= Q156), E158 (= E177), H191 (= H209)
- binding magnesium ion: S42 (= S55), Q81 (= Q97)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3 (see paper)
35% identity, 81% coverage: 16:235/273 of query aligns to 3:217/371 of 3puxA
- binding adenosine-5'-diphosphate: W12 (≠ F25), G38 (= G51), C39 (≠ A52), G40 (= G53), K41 (= K54), S42 (= S55), T43 (= T56), R128 (= R141), S134 (= S153), Q137 (= Q156)
- binding beryllium trifluoride ion: S37 (≠ N50), G38 (= G51), K41 (= K54), Q81 (= Q97), S134 (= S153), G136 (= G155), H191 (= H209)
- binding magnesium ion: S42 (= S55), Q81 (= Q97)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4 (see paper)
35% identity, 81% coverage: 16:235/273 of query aligns to 3:217/371 of 3puwA
- binding adenosine-5'-diphosphate: W12 (≠ F25), V17 (≠ A30), G38 (= G51), C39 (≠ A52), G40 (= G53), K41 (= K54), S42 (= S55), T43 (= T56), R128 (= R141), A132 (≠ S151), S134 (= S153), Q137 (= Q156)
- binding tetrafluoroaluminate ion: S37 (≠ N50), G38 (= G51), K41 (= K54), Q81 (= Q97), S134 (= S153), G135 (= G154), G136 (= G155), E158 (= E177), H191 (= H209)
- binding magnesium ion: S42 (= S55), Q81 (= Q97)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4 (see paper)
35% identity, 81% coverage: 16:235/273 of query aligns to 3:217/371 of 3puvA
- binding adenosine-5'-diphosphate: W12 (≠ F25), V17 (≠ A30), G38 (= G51), C39 (≠ A52), G40 (= G53), K41 (= K54), S42 (= S55), T43 (= T56), R128 (= R141), A132 (≠ S151), S134 (= S153), Q137 (= Q156)
- binding magnesium ion: S42 (= S55), Q81 (= Q97)
P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 5 papers)
35% identity, 81% coverage: 16:235/273 of query aligns to 4:218/371 of P68187
- A85 (= A100) mutation to M: Suppressor of EAA loop mutations in MalFG.
- K106 (vs. gap) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V114 (≠ L122) mutation to C: Suppressor of EAA loop mutations in MalFG.
- V117 (= V125) mutation to M: Suppressor of EAA loop mutations in MalFG.
- E119 (≠ M127) mutation to K: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- A124 (≠ W132) mutation to T: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- G137 (= G155) mutation to A: Loss of maltose transport. Has greater ability to decrease mal gene expression than wild-type MalK.
- D158 (= D176) mutation to N: Loss of maltose transport but retains ability to repress mal genes.
Sites not aligning to the query:
- 228 R→C: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 241 F→I: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 267 W→G: Normal maltose transport but constitutive mal gene expression.
- 278 G→P: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 282 S→L: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 284 G→S: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 302 G→D: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 308 E→Q: Maltose transport is affected but retains ability to interact with MalT.
- 322 S→F: Resistant to inhibitory effects of alpha-methylglucoside but retains transport capacity.
- 340 G→A: Maltose transport is affected but retains ability to interact with MalT.
- 346 G→S: Normal maltose transport but constitutive mal gene expression.
- 355 F→Y: Maltose transport is affected but retains ability to interact with MalT.
1q12A Crystal structure of the atp-bound e. Coli malk (see paper)
35% identity, 81% coverage: 16:235/273 of query aligns to 1:215/367 of 1q12A
- binding adenosine-5'-triphosphate: W10 (≠ F25), S35 (≠ N50), G36 (= G51), C37 (≠ A52), G38 (= G53), K39 (= K54), S40 (= S55), T41 (= T56), R126 (= R141), A130 (≠ S151), S132 (= S153), G134 (= G155), Q135 (= Q156)
4u00A Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 81% coverage: 15:234/273 of query aligns to 2:225/241 of 4u00A
1vciA Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
31% identity, 88% coverage: 16:254/273 of query aligns to 7:236/353 of 1vciA
3c4jA Abc protein artp in complex with atp-gamma-s
31% identity, 77% coverage: 15:224/273 of query aligns to 3:211/242 of 3c4jA
3c41J Abc protein artp in complex with amp-pnp/mg2+
31% identity, 77% coverage: 15:224/273 of query aligns to 3:211/242 of 3c41J
2olkA Abc protein artp in complex with adp-beta-s
31% identity, 77% coverage: 15:224/273 of query aligns to 3:211/242 of 2olkA
2oljA Abc protein artp in complex with adp/mg2+
31% identity, 77% coverage: 15:224/273 of query aligns to 3:211/242 of 2oljA
2d62A Crystal structure of multiple sugar binding transport atp- binding protein
32% identity, 81% coverage: 16:236/273 of query aligns to 7:228/375 of 2d62A
8wm7D Cryo-em structure of cyanobacterial nitrate/nitrite transporter nrtbcd in complex with signalling protein pii (see paper)
33% identity, 78% coverage: 15:227/273 of query aligns to 4:214/257 of 8wm7D
8w9mD Cryo-em structure of the cyanobacterial nitrate transporter nrtbcd in complex with atp (see paper)
33% identity, 78% coverage: 15:227/273 of query aligns to 2:212/256 of 8w9mD
- binding adenosine-5'-triphosphate: Y12 (≠ F25), H40 (≠ D49), S41 (≠ N50), G42 (= G51), G44 (= G53), K45 (= K54), S46 (= S55), T47 (= T56), Q82 (= Q97), Q135 (≠ S151), S137 (= S153), G139 (= G155), M140 (≠ Q156), H194 (= H209)
- binding magnesium ion: S46 (= S55), Q82 (= Q97)
P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
31% identity, 78% coverage: 15:228/273 of query aligns to 17:225/378 of P69874
- C26 (≠ N24) mutation to A: Lower ATPase activity and transport efficiency.
- F27 (= F25) mutation to L: Lower ATPase activity and transport efficiency.
- F45 (≠ V43) mutation to L: Lower ATPase activity and transport efficiency.
- C54 (≠ A52) mutation to T: Loss of ATPase activity and transport.
- L60 (≠ V58) mutation to F: Lower ATPase activity and transport efficiency.
- L76 (≠ F74) mutation to P: Lower ATPase activity and transport efficiency.
- V135 (≠ T133) mutation to M: Loss of ATPase activity and transport.
- D172 (= D176) mutation to N: Loss of ATPase activity and transport.
Sites not aligning to the query:
- 276 C→A: Lower ATPase activity and transport efficiency.
- 297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.
Query Sequence
>YP_004142091.1 NCBI__GCF_000185905.1:YP_004142091.1
MTDTSDEPVPAGELVLSLRGVSKNFGAVSALTDIDLDVHAGEVVALVGDNGAGKSTLVKI
LAGVHQPSSGTISFRGKPVTLADPSAALTLGIATVFQDLALCENLDIVANIFLGRELSPL
RLDEVAMEVRAWTLLNELSARIPSVREVVASLSGGQRQTVAIARSLLLEPKLILLDEPTA
ALGVAQTAEVLNLIERVRDRGLGVVIISHNMEDVRAVADRIVVLRLGRNNGIFSPDASNQ
ELVSAITGASNNSVSRRAERRQARQDQTQEPRP
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory