SitesBLAST
Comparing YP_004142733.1 NCBI__GCF_000185905.1:YP_004142733.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6umfA Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6umfA
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide: L185 (≠ I104), L187 (≠ E108), Y258 (= Y179)
6uljA Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6uljA
6ulaA Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6ulaA
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide: K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), N188 (≠ H109), Y258 (= Y179)
6ukbA Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6ukbA
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide: K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), Y258 (= Y179)
6ujmA Crystal structure of human gac in complex with inhibitor upgl00013
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6ujmA
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide: K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), Y258 (= Y179)
6umcB Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/410 of 6umcB
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide: K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), E189 (= E110), Y258 (= Y179)
6ujgA Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/410 of 6ujgA
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding N-{5-[(3S)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide: K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), Y258 (= Y179)
5wj6A Crystal structure of glutaminasE C in complex with inhibitor 2-phenyl- n-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino) piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (upgl-00004) (see paper)
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/410 of 5wj6A
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide: R181 (≠ P100), K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), N188 (≠ H109), E189 (= E110), Y258 (= Y179)
5i94A Crystal structure of human glutaminasE C in complex with the inhibitor upgl-00019 (see paper)
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/410 of 5i94A
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide: R181 (≠ P100), K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), Y258 (= Y179)
P77454 Glutaminase 1; EC 3.5.1.2 from Escherichia coli (strain K12) (see 2 papers)
40% identity, 97% coverage: 7:313/315 of query aligns to 4:308/310 of P77454
- K69 (= K73) mutation to A: Loss of activity.
- N117 (= N120) mutation to A: Loss of activity.
- S160 (= S165) mutation to A: Loss of activity.
- E161 (= E166) mutation to A: Strongly reduced activity.
- Q162 (≠ R167) mutation to A: No effect.
- N168 (= N173) mutation to A: Loss of activity.
- Y192 (= Y197) mutation to A: Loss of activity.
- Y244 (= Y249) mutation to A: Loss of activity.
- S260 (= S265) mutation to A: Reduced activity.
- K294 (≠ I299) modified: N6-acetyllysine
6umdB Crystal structure of human gac in complex with inhibitor upgl00012
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6umdB
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide: R181 (≠ P100), K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), N188 (≠ H109), E189 (= E110), Y258 (= Y179)
6ul9B Crystal structure of human gac in complex with inhibitor upgl00023
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/409 of 6ul9B
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide: R181 (≠ P100), K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), N188 (≠ H109), E189 (= E110), Y258 (= Y179)
8jubA Crystal structure of glutaminasE C in complex with compound 27 (see paper)
37% identity, 92% coverage: 20:310/315 of query aligns to 92:383/401 of 8jubA
5fi7A Crystal structure of human gac in complex with inhibitor upgl_00015: 2-phenyl-~{n}-[5-[(3~{s})-3-[[5-(2-phenylethanoylamino)-1,3,4- thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide (see paper)
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/410 of 5fi7A
- active site: S150 (= S70), K153 (= K73), Y278 (= Y197), Y330 (= Y249), V348 (= V267)
- binding 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide: K184 (≠ S103), L185 (≠ I104), F186 (≠ L107), L187 (≠ E108), E189 (= E110), Y258 (= Y179)
5fi6A Crystal structure of human gac in complex with inhibitor upgl_00011: 2-phenyl-~{n}-[5-[[(3~{s})-1-[5-(2-phenylethanoylamino)-1,3,4- thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2- yl]ethanamide (see paper)
37% identity, 92% coverage: 20:310/315 of query aligns to 100:391/410 of 5fi6A