Comparing YP_426618.1 NCBI__GCF_000013085.1:YP_426618.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
51% identity, 71% coverage: 4:847/1182 of query aligns to 5:836/841 of 8g3hA
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
32% identity, 99% coverage: 7:1182/1182 of query aligns to 11:1192/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
30% identity, 99% coverage: 8:1182/1182 of query aligns to 26:1230/1265 of Q99707
8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
44% identity, 46% coverage: 635:1182/1182 of query aligns to 4:506/507 of 8sseA
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
30% identity, 50% coverage: 8:602/1182 of query aligns to 10:598/611 of 4cczA
5vooA Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
47% identity, 23% coverage: 343:618/1182 of query aligns to 5:280/282 of 5vooA
3bulA E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
33% identity, 47% coverage: 629:1182/1182 of query aligns to 5:542/577 of 3bulA
3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound (see paper)
33% identity, 47% coverage: 629:1182/1182 of query aligns to 5:542/576 of 3ivaA
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
31% identity, 48% coverage: 8:577/1182 of query aligns to 11:538/560 of 3bofA
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
31% identity, 48% coverage: 8:577/1182 of query aligns to 11:538/559 of 1q8jA
1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase (see paper)
42% identity, 18% coverage: 629:841/1182 of query aligns to 5:218/246 of 1bmtA
3k13C Structure of the pterin-binding domain metr of 5- methyltetrahydrofolate-homocysteine methyltransferase from bacteroides thetaiotaomicron
31% identity, 22% coverage: 340:603/1182 of query aligns to 4:271/287 of 3k13C
2ycjA Methyltransferase bound with methyltetrahydrofolate (see paper)
32% identity, 21% coverage: 330:576/1182 of query aligns to 1:237/271 of 2ycjA
2yciX Methyltransferase native (see paper)
32% identity, 21% coverage: 330:576/1182 of query aligns to 1:237/271 of 2yciX
2yckX Methyltransferase bound with tetrahydrofolate (see paper)
32% identity, 21% coverage: 330:576/1182 of query aligns to 2:238/272 of 2yckX
1mskA Methionine synthase (activation domain) (see paper)
34% identity, 17% coverage: 979:1182/1182 of query aligns to 82:292/327 of 1mskA
Sites not aligning to the query:
6bdyA Crystal structure of the meth reactivation domain bound to sinefungin (see paper)
34% identity, 17% coverage: 979:1182/1182 of query aligns to 82:292/326 of 6bdyA
Sites not aligning to the query:
7xcnP Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
31% identity, 14% coverage: 662:831/1182 of query aligns to 36:209/215 of 7xcnP
4djfA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate and ti(iii) citrate reductant (see paper)
32% identity, 20% coverage: 340:575/1182 of query aligns to 1:227/262 of 4djfA
4djeA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate (see paper)
32% identity, 20% coverage: 340:575/1182 of query aligns to 1:227/262 of 4djeA
>YP_426618.1 NCBI__GCF_000013085.1:YP_426618.1
MSRFLDHLRNRVLLCDGGMGSLVQAMDLSVDGDFMGRENCTEVLNLSRPDVVRDIHTRYF
AAGADCVETNTFGGSTLTLAEFDLADRTREINRRAAEIAREAAESFADGRDRFVLGSIGP
GTKLPSLGHIDYDTLKDAITVQCEGLIEGGADAILVETCQDPLQFKAAINAAKAARLALG
SDTAILLQVTVETTGTLLVGADIAAAATVAHALGVDSLGLNCATGPQEMSEHVRWLKENW
PGLISLQPNAGLPELLDGKTHYPLTPAELADWHGRFIREDGVNLIGGCCGTTPDHIAAVN
AMLETLGQGRRPAPVKRSVHWVPSVASLYGAVPMRQENAFLSIGERCNANGSKKFRTFQD
NEDWDAIVGMAREQVKEGSHTLDVCTAFVGRKEGADMTEVVSRLRGGVNAPLVIDSTETP
VLTQALKLYGGKAIINSINFEDGEESAAQRLALAREFGAAVIALTIDEEGMAKDAEAKLR
IAHRLYDFAVTQHGLPASDLMFDPLTFTICTGNTDDRRLGLETLDAIRRIRTELPECQII
LGLSNISFGLKPVARHVLNSVFLDKAVEAGMTGAIVHISKILPLHKIPADEVKAAEDLIF
DRRAPGYDPLHAFIALFEDRSETKVAVKRAETVEERLKQRIVDGDRLGLDADLTEAMGKY
PPLEIINSLLLDGMKVVGELFGAGKMQLPFVLQSAETMKAAVAFLEPHMEKIEGQEKGII
VLATVKGDVHDIGKNLVDIILSNNGYKVINIGIKQPIAAILASARENRADAIGMSGLLVK
STVIMKDNLEEMAREGWNTPVLLGGAALTRAFVEEDCVSAYAGSGRVAYARDAFDGLDLM
AKVAEGRFDTHLSAVQQKRAGRPSRRPKAPPLWPANDPSSKIAPRTLDDQDTAIHKISER
PVDAEEILLRRAELARDHVVPTPPFWGAKVLESISLKSLVPYINEATLFQFQWGFRKGGR
TREEWKDWAASEIRPIMFDMLKTCAQEEILKPRAVYGFWKAASQGDAIVLFAEDGTTEVG
RFDLPRQTIEGGICLADFVRDIDSGERDVIALQAVTVGARASDVCRDWFAANRYKDYLYL
HGISVEVAEAMAEYVHKRIRAELGFAAEEARDIERMIKQEYRGSRYSFGYPACPNLGDQR
QLLDLLGAERIELDLSDEDELVPEQSTSALVLLHPQAKYFRI
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory