Sites on a Tree

 

Download tree, alignment (8 x 435), or descriptions, or see permanent link to this page, or start over.

Upload descriptions:
The table should be tab-delimited with the sequence identifier in the 1st column and the description in the 2nd column. Optionally, add fields named color and URL.

Select positions to show: in

Or see functional positions, see filtered positions, or see all positions.

Zoomed into a clade of 3 proteins, or see all 8 proteins.

Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.

Find sequence pattern:

Highlight proteins:

BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] BRENDA__A0A1D3TXG7BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] 1.000 BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] BT2402BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] HMPREF1058_RS14725HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum]BRENDA__A0A1D3TXG7 putative phosphoglycerate mutase [Anaerobium acetethylicum] BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482]BT2402 alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04]HMPREF1058_RS14725 alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] 0.5 /site download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory