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Showing 10 alignment positions with known function (in at least one sequence) from BioLiP or SwissProt.
Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.
Lawrence Berkeley National Laboratory