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Showing 10 alignment positions with known function (in at least one sequence) from BioLiP or SwissProt.

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Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.

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1.000 BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] 1.000 BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 12#12 Alignment position 41#41 Alignment position 369#369 Alignment position 324#324 Alignment position 395#395 Alignment position 59#59 Alignment position 378#378 Alignment position 328#328 Alignment position 368#368 Alignment position 396#396 putative phosphoglycerate mutase [Anaerobium acetethylicum] BRENDA__A0A1D3TXG7 putative phosphoglycerate mutase [Anaerobium acetethylicum] BRENDA__A0A1D3TXG7 at #12: D9 BRENDA__A0A1D3TXG7 at #12: D9 D BRENDA__A0A1D3TXG7 at #41: K38 BRENDA__A0A1D3TXG7 at #41: K38 K BRENDA__A0A1D3TXG7 at #59: S56 BRENDA__A0A1D3TXG7 at #59: S56 S BRENDA__A0A1D3TXG7 at #324: D299 BRENDA__A0A1D3TXG7 at #324: D299 D BRENDA__A0A1D3TXG7 at #328: H303 BRENDA__A0A1D3TXG7 at #328: H303 H BRENDA__A0A1D3TXG7 at #368: D343 BRENDA__A0A1D3TXG7 at #368: D343 D BRENDA__A0A1D3TXG7 at #369: H344 BRENDA__A0A1D3TXG7 at #369: H344 H BRENDA__A0A1D3TXG7 at #378: H353 BRENDA__A0A1D3TXG7 at #378: H353 H BRENDA__A0A1D3TXG7 at #395: L369 BRENDA__A0A1D3TXG7 at #395: L369 L BRENDA__A0A1D3TXG7 at #396: E370 BRENDA__A0A1D3TXG7 at #396: E370 E alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] BT2402 alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] BT2402 at #12: D9 BT2402 at #12: D9 D BT2402 at #41: R38 BT2402 at #41: R38 R BT2402 at #59: S56 BT2402 at #59: S56 S BT2402 at #324: D302 BT2402 at #324: D302 D BT2402 at #328: H306 BT2402 at #328: H306 H BT2402 at #368: D346 BT2402 at #368: D346 D BT2402 at #369: H347 BT2402 at #369: H347 H BT2402 at #378: H356 BT2402 at #378: H356 H BT2402 at #395: P372 BT2402 at #395: P372 P BT2402 at #396: D373 BT2402 at #396: D373 D alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] HMPREF1058_RS14725 alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] HMPREF1058_RS14725 at #12: D9 HMPREF1058_RS14725 at #12: D9 D HMPREF1058_RS14725 at #41: A38 HMPREF1058_RS14725 at #41: A38 A HMPREF1058_RS14725 at #59: S56 HMPREF1058_RS14725 at #59: S56 S HMPREF1058_RS14725 at #324: D302 HMPREF1058_RS14725 at #324: D302 D HMPREF1058_RS14725 at #328: H306 HMPREF1058_RS14725 at #328: H306 H HMPREF1058_RS14725 at #368: D346 HMPREF1058_RS14725 at #368: D346 D HMPREF1058_RS14725 at #369: H347 HMPREF1058_RS14725 at #369: H347 H HMPREF1058_RS14725 at #378: H356 HMPREF1058_RS14725 at #378: H356 H HMPREF1058_RS14725 at #395: P372 HMPREF1058_RS14725 at #395: P372 P HMPREF1058_RS14725 at #396: D373 HMPREF1058_RS14725 at #396: D373 D download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory