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Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.

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SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] SwissProt__P58814SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] biolip__2zktBbiolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587]SwissProt__P58814 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii]biolip__2zktB structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] 0.05 /site download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory