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Showing 10 alignment positions with known function (in at least one sequence) from BioLiP or SwissProt.

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Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.

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0.832 BRENDA__Q980A0: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] 0.464 SwissProt__Q59007: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] 1.000 SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 12#12 Alignment position 41#41 Alignment position 369#369 Alignment position 324#324 Alignment position 395#395 Alignment position 59#59 Alignment position 378#378 Alignment position 328#328 Alignment position 368#368 Alignment position 396#396 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] BRENDA__Q980A0 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] BRENDA__Q980A0 at #12: D12 BRENDA__Q980A0 at #12: D12 D BRENDA__Q980A0 at #41: K41 BRENDA__Q980A0 at #41: K41 K BRENDA__Q980A0 at #59: S59 BRENDA__Q980A0 at #59: S59 S BRENDA__Q980A0 at #324: D307 BRENDA__Q980A0 at #324: D307 D BRENDA__Q980A0 at #328: H311 BRENDA__Q980A0 at #328: H311 H BRENDA__Q980A0 at #368: D348 BRENDA__Q980A0 at #368: D348 D BRENDA__Q980A0 at #369: H349 BRENDA__Q980A0 at #369: H349 H BRENDA__Q980A0 at #378: H358 BRENDA__Q980A0 at #378: H358 H BRENDA__Q980A0 at #395: N375 BRENDA__Q980A0 at #395: N375 N BRENDA__Q980A0 at #396: D376 BRENDA__Q980A0 at #396: D376 D phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__Q59007 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__Q59007 at #12: D12 SwissProt__Q59007 at #12: D12 D SwissProt__Q59007 at #41: K39 SwissProt__Q59007 at #41: K39 K SwissProt__Q59007 at #59: S57 SwissProt__Q59007 at #59: S57 S SwissProt__Q59007 at #324: D304 SwissProt__Q59007 at #324: D304 D SwissProt__Q59007 at #328: H308 SwissProt__Q59007 at #328: H308 H SwissProt__Q59007 at #368: D345 SwissProt__Q59007 at #368: D345 D SwissProt__Q59007 at #369: H346 SwissProt__Q59007 at #369: H346 H SwissProt__Q59007 at #378: H355 SwissProt__Q59007 at #378: H355 H SwissProt__Q59007 at #395: V371 SwissProt__Q59007 at #395: V371 V SwissProt__Q59007 at #396: D372 SwissProt__Q59007 at #396: D372 D phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] SwissProt__P58814 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] SwissProt__P58814 at #12: D12 SwissProt__P58814 at #12: D12 D SwissProt__P58814 at #41: K41 SwissProt__P58814 at #41: K41 K SwissProt__P58814 at #59: S59 SwissProt__P58814 at #59: S59 S SwissProt__P58814 at #324: D304 SwissProt__P58814 at #324: D304 D SwissProt__P58814 at #328: H308 SwissProt__P58814 at #328: H308 H SwissProt__P58814 at #368: D345 SwissProt__P58814 at #368: D345 D SwissProt__P58814 at #369: H346 SwissProt__P58814 at #369: H346 H SwissProt__P58814 at #378: H355 SwissProt__P58814 at #378: H355 H SwissProt__P58814 at #395: A371 SwissProt__P58814 at #395: A371 A SwissProt__P58814 at #396: D372 SwissProt__P58814 at #396: D372 D structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] biolip__2zktB structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] biolip__2zktB at #12: D12 binds zinc ion biolip__2zktB at #12: D12 binds zinc ion D biolip__2zktB at #41: E41 binds calcium ion biolip__2zktB at #41: E41 binds calcium ion E biolip__2zktB at #59: S59 binds zinc ion biolip__2zktB at #59: S59 binds zinc ion S biolip__2zktB at #324: D274 binds zinc ion biolip__2zktB at #324: D274 binds zinc ion D biolip__2zktB at #328: H278 binds zinc ion biolip__2zktB at #328: H278 binds zinc ion H biolip__2zktB at #368: D315 binds zinc ion biolip__2zktB at #368: D315 binds zinc ion D biolip__2zktB at #369: H316 binds zinc ion biolip__2zktB at #369: H316 binds zinc ion H biolip__2zktB at #378: H325 binds zinc ion biolip__2zktB at #378: H325 binds zinc ion H biolip__2zktB at #395: T341 binds calcium ion biolip__2zktB at #395: T341 binds calcium ion T biolip__2zktB at #396: D342 binds calcium ion biolip__2zktB at #396: D342 binds calcium ion D download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory