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Showing 12 alignment positions with known function (in at least one sequence) from BioLiP or SwissProt.

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Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.

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1.000 BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] 1.000 BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] 1.000 SwissProt__O28523: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] 0.832 BRENDA__Q980A0: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] 0.464 SwissProt__Q59007: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] 1.000 SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 12#12 Alignment position 41#41 Alignment position 369#369 Alignment position 324#324 Alignment position 395#395 Alignment position 59#59 Alignment position 397#397 Alignment position 378#378 Alignment position 328#328 Alignment position 368#368 Alignment position 398#398 Alignment position 396#396 putative phosphoglycerate mutase [Anaerobium acetethylicum] BRENDA__A0A1D3TXG7 putative phosphoglycerate mutase [Anaerobium acetethylicum] BRENDA__A0A1D3TXG7 at #12: D9 BRENDA__A0A1D3TXG7 at #12: D9 D BRENDA__A0A1D3TXG7 at #41: K38 BRENDA__A0A1D3TXG7 at #41: K38 K BRENDA__A0A1D3TXG7 at #59: S56 BRENDA__A0A1D3TXG7 at #59: S56 S BRENDA__A0A1D3TXG7 at #324: D299 BRENDA__A0A1D3TXG7 at #324: D299 D BRENDA__A0A1D3TXG7 at #328: H303 BRENDA__A0A1D3TXG7 at #328: H303 H BRENDA__A0A1D3TXG7 at #368: D343 BRENDA__A0A1D3TXG7 at #368: D343 D BRENDA__A0A1D3TXG7 at #369: H344 BRENDA__A0A1D3TXG7 at #369: H344 H BRENDA__A0A1D3TXG7 at #378: H353 BRENDA__A0A1D3TXG7 at #378: H353 H BRENDA__A0A1D3TXG7 at #395: L369 BRENDA__A0A1D3TXG7 at #395: L369 L BRENDA__A0A1D3TXG7 at #396: E370 BRENDA__A0A1D3TXG7 at #396: E370 E BRENDA__A0A1D3TXG7 at #397: K371 BRENDA__A0A1D3TXG7 at #397: K371 K BRENDA__A0A1D3TXG7 at #398: E372 BRENDA__A0A1D3TXG7 at #398: E372 E alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] BT2402 alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] BT2402 at #12: D9 BT2402 at #12: D9 D BT2402 at #41: R38 BT2402 at #41: R38 R BT2402 at #59: S56 BT2402 at #59: S56 S BT2402 at #324: D302 BT2402 at #324: D302 D BT2402 at #328: H306 BT2402 at #328: H306 H BT2402 at #368: D346 BT2402 at #368: D346 D BT2402 at #369: H347 BT2402 at #369: H347 H BT2402 at #378: H356 BT2402 at #378: H356 H BT2402 at #395: P372 BT2402 at #395: P372 P BT2402 at #396: D373 BT2402 at #396: D373 D BT2402 at #397: E374 BT2402 at #397: E374 E BT2402 at #398: V375 BT2402 at #398: V375 V alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] HMPREF1058_RS14725 alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] HMPREF1058_RS14725 at #12: D9 HMPREF1058_RS14725 at #12: D9 D HMPREF1058_RS14725 at #41: A38 HMPREF1058_RS14725 at #41: A38 A HMPREF1058_RS14725 at #59: S56 HMPREF1058_RS14725 at #59: S56 S HMPREF1058_RS14725 at #324: D302 HMPREF1058_RS14725 at #324: D302 D HMPREF1058_RS14725 at #328: H306 HMPREF1058_RS14725 at #328: H306 H HMPREF1058_RS14725 at #368: D346 HMPREF1058_RS14725 at #368: D346 D HMPREF1058_RS14725 at #369: H347 HMPREF1058_RS14725 at #369: H347 H HMPREF1058_RS14725 at #378: H356 HMPREF1058_RS14725 at #378: H356 H HMPREF1058_RS14725 at #395: P372 HMPREF1058_RS14725 at #395: P372 P HMPREF1058_RS14725 at #396: D373 HMPREF1058_RS14725 at #396: D373 D HMPREF1058_RS14725 at #397: C374 HMPREF1058_RS14725 at #397: C374 C HMPREF1058_RS14725 at #398: V375 HMPREF1058_RS14725 at #398: V375 V phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] SwissProt__O28523 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] SwissProt__O28523 at #12: D9 SwissProt__O28523 at #12: D9 D SwissProt__O28523 at #41: E35 SwissProt__O28523 at #41: E35 E SwissProt__O28523 at #59: S53 SwissProt__O28523 at #59: S53 S SwissProt__O28523 at #324: D302 SwissProt__O28523 at #324: D302 D SwissProt__O28523 at #328: H306 SwissProt__O28523 at #328: H306 H SwissProt__O28523 at #368: D342 SwissProt__O28523 at #368: D342 D SwissProt__O28523 at #369: H343 SwissProt__O28523 at #369: H343 H SwissProt__O28523 at #378: H352 SwissProt__O28523 at #378: H352 H SwissProt__O28523 at #395: R368 SwissProt__O28523 at #395: R368 R SwissProt__O28523 at #396: D369 SwissProt__O28523 at #396: D369 D SwissProt__O28523 at #397: E370 SwissProt__O28523 at #397: E370 E SwissProt__O28523 at #398: V371 SwissProt__O28523 at #398: V371 V phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] BRENDA__Q980A0 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] BRENDA__Q980A0 at #12: D12 BRENDA__Q980A0 at #12: D12 D BRENDA__Q980A0 at #41: K41 BRENDA__Q980A0 at #41: K41 K BRENDA__Q980A0 at #59: S59 BRENDA__Q980A0 at #59: S59 S BRENDA__Q980A0 at #324: D307 BRENDA__Q980A0 at #324: D307 D BRENDA__Q980A0 at #328: H311 BRENDA__Q980A0 at #328: H311 H BRENDA__Q980A0 at #368: D348 BRENDA__Q980A0 at #368: D348 D BRENDA__Q980A0 at #369: H349 BRENDA__Q980A0 at #369: H349 H BRENDA__Q980A0 at #378: H358 BRENDA__Q980A0 at #378: H358 H BRENDA__Q980A0 at #395: N375 BRENDA__Q980A0 at #395: N375 N BRENDA__Q980A0 at #396: D376 BRENDA__Q980A0 at #396: D376 D BRENDA__Q980A0 at #397: N377 BRENDA__Q980A0 at #397: N377 N BRENDA__Q980A0 at #398: V378 BRENDA__Q980A0 at #398: V378 V phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__Q59007 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__Q59007 at #12: D12 SwissProt__Q59007 at #12: D12 D SwissProt__Q59007 at #41: K39 SwissProt__Q59007 at #41: K39 K SwissProt__Q59007 at #59: S57 SwissProt__Q59007 at #59: S57 S SwissProt__Q59007 at #324: D304 SwissProt__Q59007 at #324: D304 D SwissProt__Q59007 at #328: H308 SwissProt__Q59007 at #328: H308 H SwissProt__Q59007 at #368: D345 SwissProt__Q59007 at #368: D345 D SwissProt__Q59007 at #369: H346 SwissProt__Q59007 at #369: H346 H SwissProt__Q59007 at #378: H355 SwissProt__Q59007 at #378: H355 H SwissProt__Q59007 at #395: V371 SwissProt__Q59007 at #395: V371 V SwissProt__Q59007 at #396: D372 SwissProt__Q59007 at #396: D372 D SwissProt__Q59007 at #397: D373 SwissProt__Q59007 at #397: D373 D SwissProt__Q59007 at #398: V374 SwissProt__Q59007 at #398: V374 V phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] SwissProt__P58814 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] SwissProt__P58814 at #12: D12 SwissProt__P58814 at #12: D12 D SwissProt__P58814 at #41: K41 SwissProt__P58814 at #41: K41 K SwissProt__P58814 at #59: S59 SwissProt__P58814 at #59: S59 S SwissProt__P58814 at #324: D304 SwissProt__P58814 at #324: D304 D SwissProt__P58814 at #328: H308 SwissProt__P58814 at #328: H308 H SwissProt__P58814 at #368: D345 SwissProt__P58814 at #368: D345 D SwissProt__P58814 at #369: H346 SwissProt__P58814 at #369: H346 H SwissProt__P58814 at #378: H355 SwissProt__P58814 at #378: H355 H SwissProt__P58814 at #395: A371 SwissProt__P58814 at #395: A371 A SwissProt__P58814 at #396: D372 SwissProt__P58814 at #396: D372 D SwissProt__P58814 at #397: Y373 SwissProt__P58814 at #397: Y373 Y SwissProt__P58814 at #398: T374 SwissProt__P58814 at #398: T374 T structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] biolip__2zktB structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] biolip__2zktB at #12: D12 binds zinc ion biolip__2zktB at #12: D12 binds zinc ion D biolip__2zktB at #41: E41 binds calcium ion biolip__2zktB at #41: E41 binds calcium ion E biolip__2zktB at #59: S59 binds zinc ion biolip__2zktB at #59: S59 binds zinc ion S biolip__2zktB at #324: D274 binds zinc ion biolip__2zktB at #324: D274 binds zinc ion D biolip__2zktB at #328: H278 binds zinc ion biolip__2zktB at #328: H278 binds zinc ion H biolip__2zktB at #368: D315 binds zinc ion biolip__2zktB at #368: D315 binds zinc ion D biolip__2zktB at #369: H316 binds zinc ion biolip__2zktB at #369: H316 binds zinc ion H biolip__2zktB at #378: H325 binds zinc ion biolip__2zktB at #378: H325 binds zinc ion H biolip__2zktB at #395: T341 binds calcium ion biolip__2zktB at #395: T341 binds calcium ion T biolip__2zktB at #396: D342 binds calcium ion biolip__2zktB at #396: D342 binds calcium ion D biolip__2zktB at #397: D343 binds calcium ion biolip__2zktB at #397: D343 binds calcium ion D biolip__2zktB at #398: T344 binds calcium ion biolip__2zktB at #398: T344 binds calcium ion T download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory