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Zoomed into a clade of 10 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

5635396_34_225: single domain, from Phenylobacterium zucineum HLK1 (has NEQ) 5650395_26_219: single domain, from Opitutus terrae PB90-1 (has NEQ) 4592619_38_216: single domain, from Planctomyces maris DSM 8797 (has NEQ) 2221277_10_210: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 2224300_9_241: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 6254732_35_232: single domain, from Chthoniobacter flavus Ellin428 (has NEQ) 557204_55_252: single domain, from Pirellula sp. 1 (has NEQ) 4590561_54_263: with other domain, from Planctomyces maris DSM 8797 (has NEQ) 2107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 (has NEQ) 2766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 5635396_34_225 has N65 EQ 5650395_26_219 has N64 EQ 4592619_38_216 has N60 EQ 2221277_10_210 has N67 EQ 2224300_9_241 has N68 EQ 6254732_35_232 has N67 EQ 557204_55_252 has N72 EQ 4590561_54_263 has N65 EQ 2107363_45_249 has N70 EQ 2766526_24_229 has N70 EQ 5635396_34_225 and 9 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 5635396_34_225 has N E85 Q 5650395_26_219 has N E84 Q 4592619_38_216 has N E71 Q 2221277_10_210 has N E94 Q 2224300_9_241 has N E117 Q 6254732_35_232 has N E87 Q 557204_55_252 has N E92 Q 4590561_54_263 has N E85 Q 2107363_45_249 has N E92 Q 2766526_24_229 has N E92 Q 5635396_34_225 and 9 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 5635396_34_225 has NE Q87 5650395_26_219 has NE Q86 4592619_38_216 has NE Q73 2221277_10_210 has NE Q96 2224300_9_241 has NE Q119 6254732_35_232 has NE Q89 557204_55_252 has NE Q94 4590561_54_263 has NE Q87 2107363_45_249 has NE Q94 2766526_24_229 has NE Q94 5635396_34_225 and 9 similar proteins have Q aligning to 166Q 0.427 0.957 5635396_34_225: single domain, from Phenylobacterium zucineum HLK1 5635396_34_2255635396_34_225: single domain, from Phenylobacterium zucineum HLK1 5650395_26_219: single domain, from Opitutus terrae PB90-1 5650395_26_2195650395_26_219: single domain, from Opitutus terrae PB90-1 0.840 4592619_38_216: single domain, from Planctomyces maris DSM 8797 4592619_38_2164592619_38_216: single domain, from Planctomyces maris DSM 8797 0.945 2221277_10_210: single domain, from Solibacter usitatus Ellin6076 2221277_10_2102221277_10_210: single domain, from Solibacter usitatus Ellin6076 2224300_9_241: single domain, from Solibacter usitatus Ellin6076 2224300_9_2412224300_9_241: single domain, from Solibacter usitatus Ellin6076 0.854 0.989 6254732_35_232: single domain, from Chthoniobacter flavus Ellin428 6254732_35_2326254732_35_232: single domain, from Chthoniobacter flavus Ellin428 0.945 557204_55_252: single domain, from Pirellula sp. 1 557204_55_252557204_55_252: single domain, from Pirellula sp. 1 4590561_54_263: with other domain, from Planctomyces maris DSM 8797 4590561_54_2634590561_54_263: with other domain, from Planctomyces maris DSM 8797 0.987 2107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 2107363_45_2492107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 2766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 2766526_24_2292766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 5635396_34_225: single domain, from Phenylobacterium zucineum HLK1 (has NEQ)5635396_34_225 single domain, from Phenylobacterium zucineum HLK1 5650395_26_219: single domain, from Opitutus terrae PB90-1 (has NEQ)5650395_26_219 single domain, from Opitutus terrae PB90-1 4592619_38_216: single domain, from Planctomyces maris DSM 8797 (has NEQ)4592619_38_216 single domain, from Planctomyces maris DSM 8797 2221277_10_210: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2221277_10_210 single domain, from Solibacter usitatus Ellin6076 2224300_9_241: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2224300_9_241 single domain, from Solibacter usitatus Ellin6076 6254732_35_232: single domain, from Chthoniobacter flavus Ellin428 (has NEQ)6254732_35_232 single domain, from Chthoniobacter flavus Ellin428 557204_55_252: single domain, from Pirellula sp. 1 (has NEQ)557204_55_252 single domain, from Pirellula sp. 1 4590561_54_263: with other domain, from Planctomyces maris DSM 8797 (has NEQ)4590561_54_263 with other domain, from Planctomyces maris DSM 8797 2107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 (has NEQ)2107363_45_249 single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 2766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 (has NEQ)2766526_24_229 single domain, from Flavobacteriales bacterium HTCC2170 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory