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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4592619_38_216: single domain, from Planctomyces maris DSM 8797 (has NEQ) 2221277_10_210: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 2224300_9_241: single domain, from Solibacter usitatus Ellin6076 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 4592619_38_216 has N60 EQ 2221277_10_210 has N67 EQ 2224300_9_241 has N68 EQ 4592619_38_216 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 4592619_38_216 has N E71 Q 2221277_10_210 has N E94 Q 2224300_9_241 has N E117 Q 4592619_38_216 and 2 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 4592619_38_216 has NE Q73 2221277_10_210 has NE Q96 2224300_9_241 has NE Q119 4592619_38_216 and 2 similar proteins have Q aligning to 166Q 4592619_38_216: single domain, from Planctomyces maris DSM 8797 4592619_38_2164592619_38_216: single domain, from Planctomyces maris DSM 8797 0.945 2221277_10_210: single domain, from Solibacter usitatus Ellin6076 2221277_10_2102221277_10_210: single domain, from Solibacter usitatus Ellin6076 2224300_9_241: single domain, from Solibacter usitatus Ellin6076 2224300_9_2412224300_9_241: single domain, from Solibacter usitatus Ellin6076 4592619_38_216: single domain, from Planctomyces maris DSM 8797 (has NEQ)4592619_38_216 single domain, from Planctomyces maris DSM 8797 2221277_10_210: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2221277_10_210 single domain, from Solibacter usitatus Ellin6076 2224300_9_241: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2224300_9_241 single domain, from Solibacter usitatus Ellin6076 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory