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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

557204_55_252: single domain, from Pirellula sp. 1 (has NEQ) 4590561_54_263: with other domain, from Planctomyces maris DSM 8797 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 557204_55_252 has N72 EQ 4590561_54_263 has N65 EQ 557204_55_252 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 557204_55_252 has N E92 Q 4590561_54_263 has N E85 Q 557204_55_252 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 557204_55_252 has NE Q94 4590561_54_263 has NE Q87 557204_55_252 and 1 similar proteins have Q aligning to 166Q 557204_55_252: single domain, from Pirellula sp. 1 557204_55_252557204_55_252: single domain, from Pirellula sp. 1 4590561_54_263: with other domain, from Planctomyces maris DSM 8797 4590561_54_2634590561_54_263: with other domain, from Planctomyces maris DSM 8797 557204_55_252: single domain, from Pirellula sp. 1 (has NEQ)557204_55_252 single domain, from Pirellula sp. 1 4590561_54_263: with other domain, from Planctomyces maris DSM 8797 (has NEQ)4590561_54_263 with other domain, from Planctomyces maris DSM 8797 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory