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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 (has NEQ) 2766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 2107363_45_249 has N70 EQ 2766526_24_229 has N70 EQ 2107363_45_249 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2107363_45_249 has N E92 Q 2766526_24_229 has N E92 Q 2107363_45_249 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 2107363_45_249 has NE Q94 2766526_24_229 has NE Q94 2107363_45_249 and 1 similar proteins have Q aligning to 166Q 2107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 2107363_45_2492107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 2766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 2766526_24_2292766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 2107363_45_249: single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 (has NEQ)2107363_45_249 single domain, near sugar dehydrogenase, from Gramella forsetii KT0803 2766526_24_229: single domain, from Flavobacteriales bacterium HTCC2170 (has NEQ)2766526_24_229 single domain, from Flavobacteriales bacterium HTCC2170 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory