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Zoomed into a clade of 19 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ) 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 (has NEQ) 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 (has NEQ) 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 (has NEQ) 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 (has NEQ) 11142916_35_241: single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 (has NEQ) 6248949_36_232: single domain, from Chthoniobacter flavus Ellin428 (has NEQ) 6248947_52_255: single domain, from Chthoniobacter flavus Ellin428 (has KIT) 6254960_116_292: single domain, from Chthoniobacter flavus Ellin428 (has NEQ) 6002492_41_212: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ) 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ) 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ) 11036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 (has NEQ) 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ) 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has NEQ) 3722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 (has NEQ) 11000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 (has NEQ) 7460989_37_237: single domain, from Pedobacter heparinus DSM 2366 (has NEQ) 10265754_21_224: single domain, from Spirosoma linguale DSM 74 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11127178_250_458 has N72 EQ 11135123_241_454 has N72 EQ 10267694_39_236 has N66 EQ 11144788_324_528 has N74 EQ 11231190_33_234 has N65 EQ 11142916_35_241 has N72 EQ 6248949_36_232 has N67 EQ 6248947_52_255 has K73 IT 6254960_116_292 has N72 EQ 6002492_41_212 has N42 EQ 10356681_30_214 has N56 EQ 10359233_256_442 has N63 EQ 11036482_44_240 has N67 EQ 11129142_59_261 has N70 EQ 11227662_34_258 has N74 EQ 3722681_42_255 has N75 EQ 11000384_42_248 has N68 EQ 7460989_37_237 has N68 EQ 10265754_21_224 has N63 EQ 11127178_250_458 and 5 similar proteins have N aligning to 134N 6248949_36_232 has N67 aligning to 134N 6248947_52_255 has K73 aligning to 134K 6254960_116_292 has N72 aligning to 134N 6002492_41_212 and 2 similar proteins have N aligning to 134N 11036482_44_240 and 6 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11127178_250_458 has N E93 Q 11135123_241_454 has N E94 Q 10267694_39_236 has N E85 Q 11144788_324_528 has N E93 Q 11231190_33_234 has N E89 Q 11142916_35_241 has N E95 Q 6248949_36_232 has N E84 Q 6248947_52_255 has K I91 T 6254960_116_292 has N E103 Q 6002492_41_212 has N E61 Q 10356681_30_214 has N E70 Q 10359233_256_442 has N E77 Q 11036482_44_240 has N E87 Q 11129142_59_261 has N E92 Q 11227662_34_258 has N E95 Q 3722681_42_255 has N E97 Q 11000384_42_248 has N E90 Q 7460989_37_237 has N E90 Q 10265754_21_224 has N E85 Q 11127178_250_458 and 5 similar proteins have E aligning to 164E 6248949_36_232 has E84 aligning to 164E 6248947_52_255 has I91 aligning to 164I 6254960_116_292 has E103 aligning to 164E 6002492_41_212 and 2 similar proteins have E aligning to 164E 11036482_44_240 and 6 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11127178_250_458 has NE Q95 11135123_241_454 has NE Q96 10267694_39_236 has NE Q87 11144788_324_528 has NE Q95 11231190_33_234 has NE Q91 11142916_35_241 has NE Q97 6248949_36_232 has NE Q86 6248947_52_255 has KI T93 6254960_116_292 has NE Q105 6002492_41_212 has NE Q63 10356681_30_214 has NE Q72 10359233_256_442 has NE Q79 11036482_44_240 has NE Q89 11129142_59_261 has NE Q94 11227662_34_258 has NE Q97 3722681_42_255 has NE Q99 11000384_42_248 has NE Q92 7460989_37_237 has NE Q92 10265754_21_224 has NE Q87 11127178_250_458 and 5 similar proteins have Q aligning to 166Q 6248949_36_232 has Q86 aligning to 166Q 6248947_52_255 has T93 aligning to 166T 6254960_116_292 has Q105 aligning to 166Q 6002492_41_212 and 2 similar proteins have Q aligning to 166Q 11036482_44_240 and 6 similar proteins have Q aligning to 166Q 0.932 0.920 0.259 0.802 0.820 11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11127178_250_45811127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 11135123_241_45411135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 0.324 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 10267694_39_23610267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 0.859 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 11144788_324_52811144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 11231190_33_23411231190_33_234: single domain, from Cyclobacterium marinum DSM 745 11142916_35_241: single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 11142916_35_24111142916_35_241: single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 0.710 6248949_36_232: single domain, from Chthoniobacter flavus Ellin428 6248949_36_2326248949_36_232: single domain, from Chthoniobacter flavus Ellin428 0.929 6248947_52_255: single domain, from Chthoniobacter flavus Ellin428 6248947_52_2556248947_52_255: single domain, from Chthoniobacter flavus Ellin428 6254960_116_292: single domain, from Chthoniobacter flavus Ellin428 6254960_116_2926254960_116_292: single domain, from Chthoniobacter flavus Ellin428 0.936 6002492_41_212: single domain, from Verrucomicrobium spinosum DSM 4136 6002492_41_2126002492_41_212: single domain, from Verrucomicrobium spinosum DSM 4136 0.879 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 10356681_30_21410356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_44210359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 0.958 0.953 11036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 11036482_44_24011036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 0.953 0.948 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11129142_59_26111129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 11227662_34_25811227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 0.866 0.672 3722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 3722681_42_2553722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 11000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 11000384_42_24811000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 7460989_37_237: single domain, from Pedobacter heparinus DSM 2366 7460989_37_2377460989_37_237: single domain, from Pedobacter heparinus DSM 2366 10265754_21_224: single domain, from Spirosoma linguale DSM 74 10265754_21_22410265754_21_224: single domain, from Spirosoma linguale DSM 74 11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ)11127178_250_458 tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 (has NEQ)11135123_241_454 tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 (has NEQ)10267694_39_236 single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 (has NEQ)11144788_324_528 with other domain, from Runella slithyformis LSU4, DSM 19594 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 (has NEQ)11231190_33_234 single domain, from Cyclobacterium marinum DSM 745 11142916_35_241: single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 (has NEQ)11142916_35_241 single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 6248949_36_232: single domain, from Chthoniobacter flavus Ellin428 (has NEQ)6248949_36_232 single domain, from Chthoniobacter flavus Ellin428 6248947_52_255: single domain, from Chthoniobacter flavus Ellin428 (has KIT)6248947_52_255 single domain, from Chthoniobacter flavus Ellin428 6254960_116_292: single domain, from Chthoniobacter flavus Ellin428 (has NEQ)6254960_116_292 single domain, from Chthoniobacter flavus Ellin428 6002492_41_212: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ)6002492_41_212 single domain, from Verrucomicrobium spinosum DSM 4136 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ)10356681_30_214 single domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ)10359233_256_442 tandem domain, from Coraliomargarita akajimensis DSM 45221 11036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 (has NEQ)11036482_44_240 single domain, from Niastella koreensis GR20-10, DSM 17620 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ)11129142_59_261 single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has NEQ)11227662_34_258 single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 3722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 (has NEQ)3722681_42_255 single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 11000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 (has NEQ)11000384_42_248 tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 7460989_37_237: single domain, from Pedobacter heparinus DSM 2366 (has NEQ)7460989_37_237 single domain, from Pedobacter heparinus DSM 2366 10265754_21_224: single domain, from Spirosoma linguale DSM 74 (has NEQ)10265754_21_224 single domain, from Spirosoma linguale DSM 74 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory