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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

0.932 0.920 0.259 0.802 0.820 11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 0.324 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 0.859 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 11142916_35_241: single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 0.710 6248949_36_232: single domain, from Chthoniobacter flavus Ellin428 0.929 6248947_52_255: single domain, from Chthoniobacter flavus Ellin428 6254960_116_292: single domain, from Chthoniobacter flavus Ellin428 0.936 6002492_41_212: single domain, from Verrucomicrobium spinosum DSM 4136 0.879 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11127178_250_458 tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 11135123_241_454 tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 10267694_39_236 single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 with other domain, from Runella slithyformis LSU4, DSM 19594 11144788_324_528 with other domain, from Runella slithyformis LSU4, DSM 19594 single domain, from Cyclobacterium marinum DSM 745 11231190_33_234 single domain, from Cyclobacterium marinum DSM 745 single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 11142916_35_241 single domain, near sugar dehydrogenase, from Runella slithyformis LSU4, DSM 19594 single domain, from Chthoniobacter flavus Ellin428 6248949_36_232 single domain, from Chthoniobacter flavus Ellin428 single domain, from Chthoniobacter flavus Ellin428 6248947_52_255 single domain, from Chthoniobacter flavus Ellin428 single domain, from Chthoniobacter flavus Ellin428 6254960_116_292 single domain, from Chthoniobacter flavus Ellin428 single domain, from Verrucomicrobium spinosum DSM 4136 6002492_41_212 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Coraliomargarita akajimensis DSM 45221 10356681_30_214 single domain, from Coraliomargarita akajimensis DSM 45221 tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442 tandem domain, from Coraliomargarita akajimensis DSM 45221 download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory