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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ) 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 (has NEQ) 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 (has NEQ) 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 (has NEQ) 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11127178_250_458 has N72 EQ 11135123_241_454 has N72 EQ 10267694_39_236 has N66 EQ 11144788_324_528 has N74 EQ 11231190_33_234 has N65 EQ 11127178_250_458 and 4 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11127178_250_458 has N E93 Q 11135123_241_454 has N E94 Q 10267694_39_236 has N E85 Q 11144788_324_528 has N E93 Q 11231190_33_234 has N E89 Q 11127178_250_458 and 4 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11127178_250_458 has NE Q95 11135123_241_454 has NE Q96 10267694_39_236 has NE Q87 11144788_324_528 has NE Q95 11231190_33_234 has NE Q91 11127178_250_458 and 4 similar proteins have Q aligning to 166Q 0.820 11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11127178_250_45811127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 11135123_241_45411135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 0.324 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 10267694_39_23610267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 0.859 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 11144788_324_52811144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 11231190_33_23411231190_33_234: single domain, from Cyclobacterium marinum DSM 745 11127178_250_458: tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ)11127178_250_458 tandem domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11135123_241_454: tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 (has NEQ)11135123_241_454 tandem domain, from Haliscomenobacter hydrossis O, DSM 1100 10267694_39_236: single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 (has NEQ)10267694_39_236 single domain, near sugar dehydrogenase, from Spirosoma linguale DSM 74 11144788_324_528: with other domain, from Runella slithyformis LSU4, DSM 19594 (has NEQ)11144788_324_528 with other domain, from Runella slithyformis LSU4, DSM 19594 11231190_33_234: single domain, from Cyclobacterium marinum DSM 745 (has NEQ)11231190_33_234 single domain, from Cyclobacterium marinum DSM 745 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory