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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ) 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 10356681_30_214 has N56 EQ 10359233_256_442 has N63 EQ 10356681_30_214 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 10356681_30_214 has N E70 Q 10359233_256_442 has N E77 Q 10356681_30_214 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 10356681_30_214 has NE Q72 10359233_256_442 has NE Q79 10356681_30_214 and 1 similar proteins have Q aligning to 166Q 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 10356681_30_21410356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_44210359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ)10356681_30_214 single domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ)10359233_256_442 tandem domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory