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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.879 10356681_30_214: single domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442: tandem domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Coraliomargarita akajimensis DSM 45221 10356681_30_214 single domain, from Coraliomargarita akajimensis DSM 45221 10356681_30_214 at #155 10356681_30_214 at #155 - 10356681_30_214 at #156 10356681_30_214 at #156 - 10356681_30_214 at #157 10356681_30_214 at #157 - 10356681_30_214 at #158 10356681_30_214 at #158 - 10356681_30_214 at #159 10356681_30_214 at #159 - 10356681_30_214 at #160 10356681_30_214 at #160 - 10356681_30_214 at #162 10356681_30_214 at #162 - 10356681_30_214 at #164 10356681_30_214 at #164 - 10356681_30_214 at #165 10356681_30_214 at #165 - 10356681_30_214 at #168 10356681_30_214 at #168 - 10356681_30_214 at #169: M2 10356681_30_214 at #169: M2 M 10356681_30_214 at #171: E3 10356681_30_214 at #171: E3 E 10356681_30_214 at #172: H4 10356681_30_214 at #172: H4 H 10356681_30_214 at #180: W5 10356681_30_214 at #180: W5 W 10356681_30_214 at #181: R6 10356681_30_214 at #181: R6 R 10356681_30_214 at #185: T7 10356681_30_214 at #185: T7 T 10356681_30_214 at #186: S8 10356681_30_214 at #186: S8 S 10356681_30_214 at #187: K9 10356681_30_214 at #187: K9 K 10356681_30_214 at #188: Q10 10356681_30_214 at #188: Q10 Q 10356681_30_214 at #189: T11 10356681_30_214 at #189: T11 T 10356681_30_214 at #190 10356681_30_214 at #190 - 10356681_30_214 at #191: G12 10356681_30_214 at #191: G12 G 10356681_30_214 at #195: P13 10356681_30_214 at #195: P13 P 10356681_30_214 at #196: G14 10356681_30_214 at #196: G14 G 10356681_30_214 at #197: G15 10356681_30_214 at #197: G15 G 10356681_30_214 at #198: W16 10356681_30_214 at #198: W16 W 10356681_30_214 at #235: I18 10356681_30_214 at #235: I18 I 10356681_30_214 at #236: N19 10356681_30_214 at #236: N19 N 10356681_30_214 at #237: P20 10356681_30_214 at #237: P20 P 10356681_30_214 at #238: E21 10356681_30_214 at #238: E21 E 10356681_30_214 at #240: G22 10356681_30_214 at #240: G22 G 10356681_30_214 at #268: V23 10356681_30_214 at #268: V23 V 10356681_30_214 at #269: I24 10356681_30_214 at #269: I24 I 10356681_30_214 at #270: H25 10356681_30_214 at #270: H25 H 10356681_30_214 at #294 10356681_30_214 at #294 - 10356681_30_214 at #295: L26 10356681_30_214 at #295: L26 L 10356681_30_214 at #296: I27 10356681_30_214 at #296: I27 I 10356681_30_214 at #297: P28 10356681_30_214 at #297: P28 P 10356681_30_214 at #298: H29 10356681_30_214 at #298: H29 H 10356681_30_214 at #299: K30 10356681_30_214 at #299: K30 K 10356681_30_214 at #300: S31 10356681_30_214 at #300: S31 S 10356681_30_214 at #301: G32 10356681_30_214 at #301: G32 G 10356681_30_214 at #303: A33 10356681_30_214 at #303: A33 A 10356681_30_214 at #304: L34 10356681_30_214 at #304: L34 L 10356681_30_214 at #305: V35 10356681_30_214 at #305: V35 V 10356681_30_214 at #306: S36 10356681_30_214 at #306: S36 S 10356681_30_214 at #312: K37 10356681_30_214 at #312: K37 K 10356681_30_214 at #318: E38 10356681_30_214 at #318: E38 E 10356681_30_214 at #321: K39 10356681_30_214 at #321: K39 K 10356681_30_214 at #322: F40 10356681_30_214 at #322: F40 F 10356681_30_214 at #324: L41 10356681_30_214 at #324: L41 L 10356681_30_214 at #326: D42 10356681_30_214 at #326: D42 D 10356681_30_214 at #327: F43 10356681_30_214 at #327: F43 F 10356681_30_214 at #328: E44 10356681_30_214 at #328: E44 E 10356681_30_214 at #329: L45 10356681_30_214 at #329: L45 L 10356681_30_214 at #330: V46 10356681_30_214 at #330: V46 V 10356681_30_214 at #331: F47 10356681_30_214 at #331: F47 F 10356681_30_214 at #332: E48 10356681_30_214 at #332: E48 E 10356681_30_214 at #333: W49 10356681_30_214 at #333: W49 W 10356681_30_214 at #334: K50 10356681_30_214 at #334: K50 K 10356681_30_214 at #335: V51 10356681_30_214 at #335: V51 V 10356681_30_214 at #351: A52 10356681_30_214 at #351: A52 A 10356681_30_214 at #352: K53 10356681_30_214 at #352: K53 K 10356681_30_214 at #354: G54 10356681_30_214 at #354: G54 G 10356681_30_214 at #355: V55 10356681_30_214 at #355: V55 V 10356681_30_214 at #385: N56 10356681_30_214 at #385: N56 N 10356681_30_214 at #386: S57 10356681_30_214 at #386: S57 S 10356681_30_214 at #387: G58 10356681_30_214 at #387: G58 G 10356681_30_214 at #388: V59 10356681_30_214 at #388: V59 V 10356681_30_214 at #389: F60 10356681_30_214 at #389: F60 F 10356681_30_214 at #390: Y61 10356681_30_214 at #390: Y61 Y 10356681_30_214 at #391: R62 10356681_30_214 at #391: R62 R 10356681_30_214 at #392: S63 10356681_30_214 at #392: S63 S 10356681_30_214 at #393: A64 10356681_30_214 at #393: A64 A 10356681_30_214 at #423 10356681_30_214 at #423 - 10356681_30_214 at #424 10356681_30_214 at #424 - 10356681_30_214 at #425 10356681_30_214 at #425 - 10356681_30_214 at #426 10356681_30_214 at #426 - 10356681_30_214 at #430 10356681_30_214 at #430 - 10356681_30_214 at #431 10356681_30_214 at #431 - 10356681_30_214 at #432: K65 10356681_30_214 at #432: K65 K 10356681_30_214 at #433: G66 10356681_30_214 at #433: G66 G 10356681_30_214 at #434: R67 10356681_30_214 at #434: R67 R 10356681_30_214 at #435: S68 10356681_30_214 at #435: S68 S 10356681_30_214 at #436: P69 10356681_30_214 at #436: P69 P 10356681_30_214 at #438: E70 10356681_30_214 at #438: E70 E 10356681_30_214 at #439: Y71 10356681_30_214 at #439: Y71 Y 10356681_30_214 at #440: Q72 10356681_30_214 at #440: Q72 Q 10356681_30_214 at #441: I73 10356681_30_214 at #441: I73 I 10356681_30_214 at #442: L74 10356681_30_214 at #442: L74 L 10356681_30_214 at #443: D75 10356681_30_214 at #443: D75 D 10356681_30_214 at #450: D76 10356681_30_214 at #450: D76 D 10356681_30_214 at #451: A77 10356681_30_214 at #451: A77 A 10356681_30_214 at #452: N78 10356681_30_214 at #452: N78 N 10356681_30_214 at #453: H79 10356681_30_214 at #453: H79 H 10356681_30_214 at #475: Q83 10356681_30_214 at #475: Q83 Q 10356681_30_214 at #476: W84 10356681_30_214 at #476: W84 W 10356681_30_214 at #477: E85 10356681_30_214 at #477: E85 E 10356681_30_214 at #478: V86 10356681_30_214 at #478: V86 V 10356681_30_214 at #479: S87 10356681_30_214 at #479: S87 S 10356681_30_214 at #480: R88 10356681_30_214 at #480: R88 R 10356681_30_214 at #481: A89 10356681_30_214 at #481: A89 A 10356681_30_214 at #482: A90 10356681_30_214 at #482: A90 A 10356681_30_214 at #483: A91 10356681_30_214 at #483: A91 A 10356681_30_214 at #484: L92 10356681_30_214 at #484: L92 L 10356681_30_214 at #485: Y93 10356681_30_214 at #485: Y93 Y 10356681_30_214 at #486: D94 10356681_30_214 at #486: D94 D 10356681_30_214 at #487: L95 10356681_30_214 at #487: L95 L 10356681_30_214 at #530: Y96 10356681_30_214 at #530: Y96 Y 10356681_30_214 at #532 10356681_30_214 at #532 - 10356681_30_214 at #533 10356681_30_214 at #533 - 10356681_30_214 at #534 10356681_30_214 at #534 - 10356681_30_214 at #535: R98 10356681_30_214 at #535: R98 R 10356681_30_214 at #544: S99 10356681_30_214 at #544: S99 S 10356681_30_214 at #545: D100 10356681_30_214 at #545: D100 D 10356681_30_214 at #548: D101 10356681_30_214 at #548: D101 D 10356681_30_214 at #549: D102 10356681_30_214 at #549: D102 D 10356681_30_214 at #550: C103 10356681_30_214 at #550: C103 C 10356681_30_214 at #551: V104 10356681_30_214 at #551: V104 V 10356681_30_214 at #552: K105 10356681_30_214 at #552: K105 K 10356681_30_214 at #553: P106 10356681_30_214 at #553: P106 P 10356681_30_214 at #554: F107 10356681_30_214 at #554: F107 F 10356681_30_214 at #555: G108 10356681_30_214 at #555: G108 G 10356681_30_214 at #556: E109 10356681_30_214 at #556: E109 E 10356681_30_214 at #557: W110 10356681_30_214 at #557: W110 W 10356681_30_214 at #558: N111 10356681_30_214 at #558: N111 N 10356681_30_214 at #559: T112 10356681_30_214 at #559: T112 T 10356681_30_214 at #560: G113 10356681_30_214 at #560: G113 G 10356681_30_214 at #561: R114 10356681_30_214 at #561: R114 R 10356681_30_214 at #562: I115 10356681_30_214 at #562: I115 I 10356681_30_214 at #565: I116 10356681_30_214 at #565: I116 I 10356681_30_214 at #566: A117 10356681_30_214 at #566: A117 A 10356681_30_214 at #568: K118 10356681_30_214 at #568: K118 K 10356681_30_214 at #570: G119 10356681_30_214 at #570: G119 G 10356681_30_214 at #571: K120 10356681_30_214 at #571: K120 K 10356681_30_214 at #572: R121 10356681_30_214 at #572: R121 R 10356681_30_214 at #588: L122 10356681_30_214 at #588: L122 L 10356681_30_214 at #589: Q123 10356681_30_214 at #589: Q123 Q 10356681_30_214 at #592: H124 10356681_30_214 at #592: H124 H 10356681_30_214 at #594: W125 10356681_30_214 at #594: W125 W 10356681_30_214 at #595: L126 10356681_30_214 at #595: L126 L 10356681_30_214 at #596: N127 10356681_30_214 at #596: N127 N 10356681_30_214 at #598: G128 10356681_30_214 at #598: G128 G 10356681_30_214 at #599: V129 10356681_30_214 at #599: V129 V 10356681_30_214 at #600: L130 10356681_30_214 at #600: L130 L 10356681_30_214 at #601: V131 10356681_30_214 at #601: V131 V 10356681_30_214 at #602: V132 10356681_30_214 at #602: V132 V 10356681_30_214 at #603: D133 10356681_30_214 at #603: D133 D 10356681_30_214 at #604: V134 10356681_30_214 at #604: V134 V 10356681_30_214 at #605: E135 10356681_30_214 at #605: E135 E 10356681_30_214 at #606: V136 10356681_30_214 at #606: V136 V 10356681_30_214 at #607: G137 10356681_30_214 at #607: G137 G 10356681_30_214 at #608: S138 10356681_30_214 at #608: S138 S 10356681_30_214 at #609: E139 10356681_30_214 at #609: E139 E 10356681_30_214 at #610: D140 10356681_30_214 at #610: D140 D 10356681_30_214 at #611: W141 10356681_30_214 at #611: W141 W 10356681_30_214 at #612: N142 10356681_30_214 at #612: N142 N 10356681_30_214 at #613: A143 10356681_30_214 at #613: A143 A 10356681_30_214 at #614: R144 10356681_30_214 at #614: R144 R 10356681_30_214 at #615: F145 10356681_30_214 at #615: F145 F 10356681_30_214 at #616: I146 10356681_30_214 at #616: I146 I 10356681_30_214 at #640: F161 10356681_30_214 at #640: F161 F 10356681_30_214 at #641: G162 10356681_30_214 at #641: G162 G 10356681_30_214 at #642: L163 10356681_30_214 at #642: L163 L 10356681_30_214 at #643: Q164 10356681_30_214 at #643: Q164 Q 10356681_30_214 at #644: K165 10356681_30_214 at #644: K165 K 10356681_30_214 at #645: G166 10356681_30_214 at #645: G166 G 10356681_30_214 at #646: S167 10356681_30_214 at #646: S167 S 10356681_30_214 at #647: I168 10356681_30_214 at #647: I168 I 10356681_30_214 at #648: W169 10356681_30_214 at #648: W169 W 10356681_30_214 at #649: L170 10356681_30_214 at #649: L170 L 10356681_30_214 at #650: Q171 10356681_30_214 at #650: Q171 Q 10356681_30_214 at #653: D172 10356681_30_214 at #653: D172 D 10356681_30_214 at #654: H173 10356681_30_214 at #654: H173 H 10356681_30_214 at #655: G174 10356681_30_214 at #655: G174 G 10356681_30_214 at #668: G175 10356681_30_214 at #668: G175 G 10356681_30_214 at #689: E176 10356681_30_214 at #689: E176 E 10356681_30_214 at #690: V177 10356681_30_214 at #690: V177 V 10356681_30_214 at #691: W178 10356681_30_214 at #691: W178 W 10356681_30_214 at #694: Y179 10356681_30_214 at #694: Y179 Y 10356681_30_214 at #695: R180 10356681_30_214 at #695: R180 R 10356681_30_214 at #696: N181 10356681_30_214 at #696: N181 N 10356681_30_214 at #697: V182 10356681_30_214 at #697: V182 V 10356681_30_214 at #698: R183 10356681_30_214 at #698: R183 R 10356681_30_214 at #699: I184 10356681_30_214 at #699: I184 I 10356681_30_214 at #700: R185 10356681_30_214 at #700: R185 R tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442 tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_256_442 at #155 10359233_256_442 at #155 - 10359233_256_442 at #156 10359233_256_442 at #156 - 10359233_256_442 at #157: E2 10359233_256_442 at #157: E2 E 10359233_256_442 at #158: D3 10359233_256_442 at #158: D3 D 10359233_256_442 at #159: L4 10359233_256_442 at #159: L4 L 10359233_256_442 at #160: F5 10359233_256_442 at #160: F5 F 10359233_256_442 at #162: A6 10359233_256_442 at #162: A6 A 10359233_256_442 at #164: T7 10359233_256_442 at #164: T7 T 10359233_256_442 at #165: G8 10359233_256_442 at #165: G8 G 10359233_256_442 at #168: D9 10359233_256_442 at #168: D9 D 10359233_256_442 at #169: F10 10359233_256_442 at #169: F10 F 10359233_256_442 at #171: S11 10359233_256_442 at #171: S11 S 10359233_256_442 at #172: N12 10359233_256_442 at #172: N12 N 10359233_256_442 at #180: W13 10359233_256_442 at #180: W13 W 10359233_256_442 at #181: T14 10359233_256_442 at #181: T14 T 10359233_256_442 at #185: N15 10359233_256_442 at #185: N15 N 10359233_256_442 at #186: P16 10359233_256_442 at #186: P16 P 10359233_256_442 at #187: K17 10359233_256_442 at #187: K17 K 10359233_256_442 at #188: G18 10359233_256_442 at #188: G18 G 10359233_256_442 at #189: G19 10359233_256_442 at #189: G19 G 10359233_256_442 at #190: P20 10359233_256_442 at #190: P20 P 10359233_256_442 at #191: V21 10359233_256_442 at #191: V21 V 10359233_256_442 at #195: G22 10359233_256_442 at #195: G22 G 10359233_256_442 at #196: K23 10359233_256_442 at #196: K23 K 10359233_256_442 at #197: G24 10359233_256_442 at #197: G24 G 10359233_256_442 at #198: W25 10359233_256_442 at #198: W25 W 10359233_256_442 at #235: S26 10359233_256_442 at #235: S26 S 10359233_256_442 at #236: I27 10359233_256_442 at #236: I27 I 10359233_256_442 at #237: E28 10359233_256_442 at #237: E28 E 10359233_256_442 at #238: N29 10359233_256_442 at #238: N29 N 10359233_256_442 at #240: G30 10359233_256_442 at #240: G30 G 10359233_256_442 at #268: I31 10359233_256_442 at #268: I31 I 10359233_256_442 at #269: V32 10359233_256_442 at #269: V32 V 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory