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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4594702_67_283: single domain, from Planctomyces maris DSM 8797 (has DQN) 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 (has EEE) BT2157 has N at position 134 (alignment position 385)N134 4594702_67_283 has D97 QN 6251338_238_441 has E75 EE 4594702_67_283 has D97 aligning to 134D 6251338_238_441 has E75 aligning to 134E BT2157 has E at position 164 (alignment position 438)E164 4594702_67_283 has D Q109 N 6251338_238_441 has E E89 E 4594702_67_283 has Q109 aligning to 164Q 6251338_238_441 has E89 aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 4594702_67_283 has DQ N111 6251338_238_441 has EE E91 4594702_67_283 has N111 aligning to 166N 6251338_238_441 has E91 aligning to 166E 4594702_67_283: single domain, from Planctomyces maris DSM 8797 4594702_67_2834594702_67_283: single domain, from Planctomyces maris DSM 8797 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 6251338_238_4416251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 4594702_67_283: single domain, from Planctomyces maris DSM 8797 (has DQN)4594702_67_283 single domain, from Planctomyces maris DSM 8797 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 (has EEE)6251338_238_441 tandem domain, from Chthoniobacter flavus Ellin428 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory