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Zoomed into a clade of 7 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 (has NEQ) 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ) 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has NEQ) 3722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 (has NEQ) 11000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 (has NEQ) 7460989_37_237: single domain, from Pedobacter heparinus DSM 2366 (has NEQ) 10265754_21_224: single domain, from Spirosoma linguale DSM 74 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11036482_44_240 has N67 EQ 11129142_59_261 has N70 EQ 11227662_34_258 has N74 EQ 3722681_42_255 has N75 EQ 11000384_42_248 has N68 EQ 7460989_37_237 has N68 EQ 10265754_21_224 has N63 EQ 11036482_44_240 and 6 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11036482_44_240 has N E87 Q 11129142_59_261 has N E92 Q 11227662_34_258 has N E95 Q 3722681_42_255 has N E97 Q 11000384_42_248 has N E90 Q 7460989_37_237 has N E90 Q 10265754_21_224 has N E85 Q 11036482_44_240 and 6 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11036482_44_240 has NE Q89 11129142_59_261 has NE Q94 11227662_34_258 has NE Q97 3722681_42_255 has NE Q99 11000384_42_248 has NE Q92 7460989_37_237 has NE Q92 10265754_21_224 has NE Q87 11036482_44_240 and 6 similar proteins have Q aligning to 166Q 0.953 11036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 11036482_44_24011036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 0.953 0.948 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11129142_59_26111129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 11227662_34_25811227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 0.866 0.672 3722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 3722681_42_2553722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 11000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 11000384_42_24811000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 7460989_37_237: single domain, from Pedobacter heparinus DSM 2366 7460989_37_2377460989_37_237: single domain, from Pedobacter heparinus DSM 2366 10265754_21_224: single domain, from Spirosoma linguale DSM 74 10265754_21_22410265754_21_224: single domain, from Spirosoma linguale DSM 74 11036482_44_240: single domain, from Niastella koreensis GR20-10, DSM 17620 (has NEQ)11036482_44_240 single domain, from Niastella koreensis GR20-10, DSM 17620 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ)11129142_59_261 single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has NEQ)11227662_34_258 single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 3722681_42_255: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 (has NEQ)3722681_42_255 single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 11000384_42_248: tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 (has NEQ)11000384_42_248 tandem domain, from Alistipes finegoldii AHN 2437, DSM 17242 7460989_37_237: single domain, from Pedobacter heparinus DSM 2366 (has NEQ)7460989_37_237 single domain, from Pedobacter heparinus DSM 2366 10265754_21_224: single domain, from Spirosoma linguale DSM 74 (has NEQ)10265754_21_224 single domain, from Spirosoma linguale DSM 74 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory