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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ) 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11129142_59_261 has N70 EQ 11227662_34_258 has N74 EQ 11129142_59_261 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11129142_59_261 has N E92 Q 11227662_34_258 has N E95 Q 11129142_59_261 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11129142_59_261 has NE Q94 11227662_34_258 has NE Q97 11129142_59_261 and 1 similar proteins have Q aligning to 166Q 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11129142_59_26111129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 11227662_34_25811227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 11129142_59_261: single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 (has NEQ)11129142_59_261 single domain, near sugar dehydrogenase, from Aquiflexum balticum BA160, DSM 16537 11227662_34_258: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has NEQ)11227662_34_258 single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory