Sites on a Tree

 

Download tree, alignment (240 x 716), positions, or descriptions, or see permanent link to this page, or start over.

Upload descriptions:
The table should be tab-delimited with the sequence identifier in the 1st column and the description in the 2nd column. Optionally, add fields named color and URL.

Select positions to show: in

Or see functional positions, see filtered positions, or see all positions.

Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

Find sequence pattern:

Highlight proteins:

3558251_5_190: single domain, from Pseudomonas stutzeri A1501 (has NEQ) 5650184_80_251: single domain, from Opitutus terrae PB90-1 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 3558251_5_190 has N57 EQ 5650184_80_251 has N41 EQ 3558251_5_190 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 3558251_5_190 has N E77 Q 5650184_80_251 has N E61 Q 3558251_5_190 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 3558251_5_190 has NE Q79 5650184_80_251 has NE Q63 3558251_5_190 and 1 similar proteins have Q aligning to 166Q 3558251_5_190: single domain, from Pseudomonas stutzeri A1501 3558251_5_1903558251_5_190: single domain, from Pseudomonas stutzeri A1501 5650184_80_251: single domain, from Opitutus terrae PB90-1 5650184_80_2515650184_80_251: single domain, from Opitutus terrae PB90-1 3558251_5_190: single domain, from Pseudomonas stutzeri A1501 (has NEQ)3558251_5_190 single domain, from Pseudomonas stutzeri A1501 5650184_80_251: single domain, from Opitutus terrae PB90-1 (has NEQ)5650184_80_251 single domain, from Opitutus terrae PB90-1 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory