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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11036133_59_263: single domain, from Niastella koreensis GR20-10, DSM 17620 (has NEQ) 11075721_6_207: single domain, from Pontibacter actiniarum KMM 6156, DSM 19842 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11036133_59_263 has N73 EQ 11075721_6_207 has N70 EQ 11036133_59_263 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11036133_59_263 has N E95 Q 11075721_6_207 has N E93 Q 11036133_59_263 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11036133_59_263 has NE Q97 11075721_6_207 has NE Q95 11036133_59_263 and 1 similar proteins have Q aligning to 166Q 11036133_59_263: single domain, from Niastella koreensis GR20-10, DSM 17620 11036133_59_26311036133_59_263: single domain, from Niastella koreensis GR20-10, DSM 17620 11075721_6_207: single domain, from Pontibacter actiniarum KMM 6156, DSM 19842 11075721_6_20711075721_6_207: single domain, from Pontibacter actiniarum KMM 6156, DSM 19842 11036133_59_263: single domain, from Niastella koreensis GR20-10, DSM 17620 (has NEQ)11036133_59_263 single domain, from Niastella koreensis GR20-10, DSM 17620 11075721_6_207: single domain, from Pontibacter actiniarum KMM 6156, DSM 19842 (has NEQ)11075721_6_207 single domain, from Pontibacter actiniarum KMM 6156, DSM 19842 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory