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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11271595_39_238: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NEQ) 4908583_34_225: single domain, from Gemmata obscuriglobus UQM 2246 (has NEQ) 6251338_25_220: tandem domain, from Chthoniobacter flavus Ellin428 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11271595_39_238 has N61 EQ 4908583_34_225 has N65 EQ 6251338_25_220 has N64 EQ 11271595_39_238 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11271595_39_238 has N E86 Q 4908583_34_225 has N E87 Q 6251338_25_220 has N E86 Q 11271595_39_238 and 2 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11271595_39_238 has NE Q88 4908583_34_225 has NE Q89 6251338_25_220 has NE Q88 11271595_39_238 and 2 similar proteins have Q aligning to 166Q 11271595_39_238: single domain, from Isosphaera pallida IS1B, ATCC 43644 11271595_39_23811271595_39_238: single domain, from Isosphaera pallida IS1B, ATCC 43644 0.247 4908583_34_225: single domain, from Gemmata obscuriglobus UQM 2246 4908583_34_2254908583_34_225: single domain, from Gemmata obscuriglobus UQM 2246 6251338_25_220: tandem domain, from Chthoniobacter flavus Ellin428 6251338_25_2206251338_25_220: tandem domain, from Chthoniobacter flavus Ellin428 11271595_39_238: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NEQ)11271595_39_238 single domain, from Isosphaera pallida IS1B, ATCC 43644 4908583_34_225: single domain, from Gemmata obscuriglobus UQM 2246 (has NEQ)4908583_34_225 single domain, from Gemmata obscuriglobus UQM 2246 6251338_25_220: tandem domain, from Chthoniobacter flavus Ellin428 (has NEQ)6251338_25_220 tandem domain, from Chthoniobacter flavus Ellin428 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory