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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4592896_57_240: single domain, from Planctomyces maris DSM 8797 (has NQQ) 9545202_270_455: with other domain, from Emiliania huxleyi CCMP1516 (has GEQ) BT2157 has N at position 134 (alignment position 385)N134 4592896_57_240 has N77 QQ 9545202_270_455 has G71 EQ 4592896_57_240 has N77 aligning to 134N 9545202_270_455 has G71 aligning to 134G BT2157 has E at position 164 (alignment position 438)E164 4592896_57_240 has N Q96 Q 9545202_270_455 has G E90 Q 4592896_57_240 has Q96 aligning to 164Q 9545202_270_455 has E90 aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 4592896_57_240 has NQ Q98 9545202_270_455 has GE Q92 4592896_57_240 and 1 similar proteins have Q aligning to 166Q 4592896_57_240: single domain, from Planctomyces maris DSM 8797 4592896_57_2404592896_57_240: single domain, from Planctomyces maris DSM 8797 9545202_270_455: with other domain, from Emiliania huxleyi CCMP1516 9545202_270_4559545202_270_455: with other domain, from Emiliania huxleyi CCMP1516 4592896_57_240: single domain, from Planctomyces maris DSM 8797 (has NQQ)4592896_57_240 single domain, from Planctomyces maris DSM 8797 9545202_270_455: with other domain, from Emiliania huxleyi CCMP1516 (has GEQ)9545202_270_455 with other domain, from Emiliania huxleyi CCMP1516 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory