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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

3722085_28_214: single domain, from Parabacteroides distasonis ATCC 8503 (has NEN) 5647962_33_212: single domain, from Opitutus terrae PB90-1 (has NQQ) BT2157 has N at position 134 (alignment position 385)N134 3722085_28_214 has N69 EN 5647962_33_212 has N59 QQ 3722085_28_214 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 3722085_28_214 has N E88 N 5647962_33_212 has N Q81 Q 3722085_28_214 has E88 aligning to 164E 5647962_33_212 has Q81 aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 3722085_28_214 has NE N90 5647962_33_212 has NQ Q83 3722085_28_214 has N90 aligning to 166N 5647962_33_212 has Q83 aligning to 166Q 3722085_28_214: single domain, from Parabacteroides distasonis ATCC 8503 3722085_28_2143722085_28_214: single domain, from Parabacteroides distasonis ATCC 8503 5647962_33_212: single domain, from Opitutus terrae PB90-1 5647962_33_2125647962_33_212: single domain, from Opitutus terrae PB90-1 3722085_28_214: single domain, from Parabacteroides distasonis ATCC 8503 (has NEN)3722085_28_214 single domain, from Parabacteroides distasonis ATCC 8503 5647962_33_212: single domain, from Opitutus terrae PB90-1 (has NQQ)5647962_33_212 single domain, from Opitutus terrae PB90-1 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory