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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.780 0.967 0.849 6254985_35_202: single domain, from Chthoniobacter flavus Ellin428 0.909 0.744 7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 0.758 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 0.806 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 0.056 4594702_67_283: single domain, from Planctomyces maris DSM 8797 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 0.982 0.796 0.978 0.447 6004649_25_232: single domain, from Verrucomicrobium spinosum DSM 4136 7470545_41_248: single domain, from Chitinophaga pinensis DSM 2588 0.752 0.825 4909907_81_246: single domain, from Gemmata obscuriglobus UQM 2246 11269095_78_293: single domain, from Isosphaera pallida IS1B, ATCC 43644 0.641 10356726_29_240: single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 4615506_175_363: with redox domain, from Lentisphaera araneosa HTCC2155 0.912 6005885_41_249: single domain, from Verrucomicrobium spinosum DSM 4136 0.580 0.735 0.421 0.541 0.473 4907078_48_238: single domain, from Gemmata obscuriglobus UQM 2246 0.909 0.890 4592216_152_332: single domain, from Planctomyces maris DSM 8797 6253284_153_334: single domain, from Chthoniobacter flavus Ellin428 0.213 0.802 557004_164_355: single domain, near sugar dehydrogenase, from Pirellula sp. 1 4612146_159_339: single domain, from Lentisphaera araneosa HTCC2155 0.880 0.840 10307987_154_329: single domain, from Pirellula staleyi DSM 6068 4616236_34_216: single domain, from Lentisphaera araneosa HTCC2155 557181_269_442: single domain, from Pirellula sp. 1 0.970 2221624_159_350: single domain, from Solibacter usitatus Ellin6076 7460876_127_321: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 554434_59_259: single domain, from Pirellula sp. 1 1937924_811_999: with other domain, from Streptomyces coelicolor A3(2) 0.808 10356341_141_326: single domain, from Coraliomargarita akajimensis DSM 45221 0.953 0.882 0.468 0.460 0.115 0.876 7398304_63_256: single domain, from Dyadobacter fermentans DSM 18053 0.886 3723559_59_253: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 0.992 5848954_85_286: single domain, from Caulobacter crescentus NA1000 0.052 Pedo557__CA265_RS22975: single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 11045354_54_254: single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 11293044_51_238: single domain, from Planctomyces brasiliensis DSM 5305 4612339_494_704: with other domain, from Lentisphaera araneosa HTCC2155 0.338 6000757_65_257: single domain, from Verrucomicrobium spinosum DSM 4136 6004177_75_267: single domain, from Verrucomicrobium spinosum DSM 4136 0.777 0.633 10356898_71_256: single domain, from Coraliomargarita akajimensis DSM 45221 4614844_78_263: single domain, from Lentisphaera araneosa HTCC2155 2220738_87_285: single domain, from Solibacter usitatus Ellin6076 Korea__Ga0059261_0549: single domain, from Sphingomonas koreensis DSMZ 15582 0.923 0.774 2221882_149_317: single domain, from Solibacter usitatus Ellin6076 6000697_153_324: single domain, from Verrucomicrobium spinosum DSM 4136 0.030 2224728_148_318: single domain, from Solibacter usitatus Ellin6076 11127748_199_365: single domain, from Aquiflexum balticum BA160, DSM 16537 1 /site single domain, from Chthoniobacter flavus Ellin428 6254985_35_202 single domain, from Chthoniobacter flavus Ellin428 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 7462545_728_927 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 single domain, from Solibacter usitatus Ellin6076 2223539_22_227 single domain, from Solibacter usitatus Ellin6076 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_234_440 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 single domain, from Gemmata obscuriglobus UQM 2246 4908012_29_247 single domain, from Gemmata obscuriglobus UQM 2246 single domain, from Planctomyces brasiliensis DSM 5305 11292817_33_232 single domain, from Planctomyces brasiliensis DSM 5305 single domain, from Planctomyces maris DSM 8797 4594702_67_283 single domain, from Planctomyces maris DSM 8797 tandem domain, from Chthoniobacter flavus Ellin428 6251338_238_441 tandem domain, from Chthoniobacter flavus Ellin428 single domain, from Verrucomicrobium spinosum DSM 4136 6004649_25_232 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Chitinophaga pinensis DSM 2588 7470545_41_248 single domain, from Chitinophaga pinensis DSM 2588 single domain, from Gemmata obscuriglobus UQM 2246 4909907_81_246 single domain, from Gemmata obscuriglobus UQM 2246 single domain, from Isosphaera pallida IS1B, ATCC 43644 11269095_78_293 single domain, from Isosphaera pallida IS1B, ATCC 43644 single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 10356726_29_240 single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 with redox domain, from Lentisphaera araneosa HTCC2155 4615506_175_363 with redox domain, from Lentisphaera araneosa HTCC2155 single domain, from Verrucomicrobium spinosum DSM 4136 6005885_41_249 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Gemmata obscuriglobus UQM 2246 4907078_48_238 single domain, from Gemmata obscuriglobus UQM 2246 single domain, from Planctomyces maris DSM 8797 4592216_152_332 single domain, from Planctomyces maris DSM 8797 single domain, from Chthoniobacter flavus Ellin428 6253284_153_334 single domain, from Chthoniobacter flavus Ellin428 single domain, near sugar dehydrogenase, from Pirellula sp. 1 557004_164_355 single domain, near sugar dehydrogenase, from Pirellula sp. 1 single domain, from Lentisphaera araneosa HTCC2155 4612146_159_339 single domain, from Lentisphaera araneosa HTCC2155 single domain, from Pirellula staleyi DSM 6068 10307987_154_329 single domain, from Pirellula staleyi DSM 6068 single domain, from Lentisphaera araneosa HTCC2155 4616236_34_216 single domain, from Lentisphaera araneosa HTCC2155 single domain, from Pirellula sp. 1 557181_269_442 single domain, from Pirellula sp. 1 single domain, from Solibacter usitatus Ellin6076 2221624_159_350 single domain, from Solibacter usitatus Ellin6076 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 7460876_127_321 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 single domain, from Pirellula sp. 1 554434_59_259 single domain, from Pirellula sp. 1 with other domain, from Streptomyces coelicolor A3(2) 1937924_811_999 with other domain, from Streptomyces coelicolor A3(2) single domain, from Coraliomargarita akajimensis DSM 45221 10356341_141_326 single domain, from Coraliomargarita akajimensis DSM 45221 single domain, from Dyadobacter fermentans DSM 18053 7398304_63_256 single domain, from Dyadobacter fermentans DSM 18053 single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 3723559_59_253 single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 single domain, from Caulobacter crescentus NA1000 5848954_85_286 single domain, from Caulobacter crescentus NA1000 single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 Pedo557__CA265_RS22975 single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 11045354_54_254 single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 single domain, from Planctomyces brasiliensis DSM 5305 11293044_51_238 single domain, from Planctomyces brasiliensis DSM 5305 with other domain, from Lentisphaera araneosa HTCC2155 4612339_494_704 with other domain, from Lentisphaera araneosa HTCC2155 single domain, from Verrucomicrobium spinosum DSM 4136 6000757_65_257 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Verrucomicrobium spinosum DSM 4136 6004177_75_267 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Coraliomargarita akajimensis DSM 45221 10356898_71_256 single domain, from Coraliomargarita akajimensis DSM 45221 single domain, from Lentisphaera araneosa HTCC2155 4614844_78_263 single domain, from Lentisphaera araneosa HTCC2155 single domain, from Solibacter usitatus Ellin6076 2220738_87_285 single domain, from Solibacter usitatus Ellin6076 single domain, from Sphingomonas koreensis DSMZ 15582 Korea__Ga0059261_0549 single domain, from Sphingomonas koreensis DSMZ 15582 single domain, from Solibacter usitatus Ellin6076 2221882_149_317 single domain, from Solibacter usitatus Ellin6076 single domain, from Verrucomicrobium spinosum DSM 4136 6000697_153_324 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Solibacter usitatus Ellin6076 2224728_148_318 single domain, from Solibacter usitatus Ellin6076 single domain, from Aquiflexum balticum BA160, DSM 16537 11127748_199_365 single domain, from Aquiflexum balticum BA160, DSM 16537 download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory