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Zoomed into a clade of 6 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6004649_25_232: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ) 7470545_41_248: single domain, from Chitinophaga pinensis DSM 2588 (has NEQ) 4909907_81_246: single domain, from Gemmata obscuriglobus UQM 2246 (has NEQ) 11269095_78_293: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NEQ) 10356726_29_240: single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 (has NEQ) 4615506_175_363: with redox domain, from Lentisphaera araneosa HTCC2155 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 6004649_25_232 has N87 EQ 7470545_41_248 has N72 EQ 4909907_81_246 has N32 EQ 11269095_78_293 has N80 EQ 10356726_29_240 has N79 EQ 4615506_175_363 has N58 EQ 6004649_25_232 and 5 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 6004649_25_232 has N E97 Q 7470545_41_248 has N E82 Q 4909907_81_246 has N E42 Q 11269095_78_293 has N E90 Q 10356726_29_240 has N E89 Q 4615506_175_363 has N E68 Q 6004649_25_232 and 5 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 6004649_25_232 has NE Q99 7470545_41_248 has NE Q84 4909907_81_246 has NE Q44 11269095_78_293 has NE Q92 10356726_29_240 has NE Q91 4615506_175_363 has NE Q70 6004649_25_232 and 5 similar proteins have Q aligning to 166Q 0.447 6004649_25_232: single domain, from Verrucomicrobium spinosum DSM 4136 6004649_25_2326004649_25_232: single domain, from Verrucomicrobium spinosum DSM 4136 7470545_41_248: single domain, from Chitinophaga pinensis DSM 2588 7470545_41_2487470545_41_248: single domain, from Chitinophaga pinensis DSM 2588 0.752 0.825 4909907_81_246: single domain, from Gemmata obscuriglobus UQM 2246 4909907_81_2464909907_81_246: single domain, from Gemmata obscuriglobus UQM 2246 11269095_78_293: single domain, from Isosphaera pallida IS1B, ATCC 43644 11269095_78_29311269095_78_293: single domain, from Isosphaera pallida IS1B, ATCC 43644 0.641 10356726_29_240: single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 10356726_29_24010356726_29_240: single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 4615506_175_363: with redox domain, from Lentisphaera araneosa HTCC2155 4615506_175_3634615506_175_363: with redox domain, from Lentisphaera araneosa HTCC2155 6004649_25_232: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ)6004649_25_232 single domain, from Verrucomicrobium spinosum DSM 4136 7470545_41_248: single domain, from Chitinophaga pinensis DSM 2588 (has NEQ)7470545_41_248 single domain, from Chitinophaga pinensis DSM 2588 4909907_81_246: single domain, from Gemmata obscuriglobus UQM 2246 (has NEQ)4909907_81_246 single domain, from Gemmata obscuriglobus UQM 2246 11269095_78_293: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NEQ)11269095_78_293 single domain, from Isosphaera pallida IS1B, ATCC 43644 10356726_29_240: single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 (has NEQ)10356726_29_240 single domain, near sugar dehydrogenase, from Coraliomargarita akajimensis DSM 45221 4615506_175_363: with redox domain, from Lentisphaera araneosa HTCC2155 (has NEQ)4615506_175_363 with redox domain, from Lentisphaera araneosa HTCC2155 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory