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Zoomed into a clade of 16 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has DEQ) 11228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has DEQ) 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 (has DEQ) 10266833_46_287: single domain, from Spirosoma linguale DSM 74 (has DEQ) 5646854_22_277: single domain, from Opitutus terrae PB90-1 (has DEQ) 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 (has DEQ) 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c (has DEQ) 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 (has DEQ) 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEE) 7044010_37_278: single domain, from Caulobacter sp. K31 (has NEE) 5708882_24_263: single domain, from Cellvibrio japonicus Ueda107 (has DEQ) 11035244_21_215: single domain, from Niastella koreensis GR20-10, DSM 17620 (has DEQ) 10359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 (has DEQ) 4593654_515_746: with redox domain, from Planctomyces maris DSM 8797 (has DEQ) 11185153_25_218: single domain, from Ornithobacterium rhinotracheale DSM 15997 (has NQQ) 3395994_38_271: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 6003772_60_269 has D50 EQ 11228697_40_270 has D78 EQ 7665029_26_279 has D105 EQ 10266833_46_287 has D96 EQ 5646854_22_277 has D106 EQ 11023056_44_295 has D100 EQ 3500619_44_289 has D107 EQ 11202245_37_274 has D105 EQ 1261712_62_315 has N92 EE 7044010_37_278 has N96 EE 5708882_24_263 has D94 EQ 11035244_21_215 has D78 EQ 10359430_45_269 has D90 EQ 4593654_515_746 has D86 EQ 11185153_25_218 has N75 QQ 3395994_38_271 has N90 EQ 6003772_60_269 and 1 similar proteins have D aligning to 134D 7665029_26_279 and 1 similar proteins have D aligning to 134D 5646854_22_277 has D106 aligning to 134D 11023056_44_295 and 2 similar proteins have D aligning to 134D 1261712_62_315 and 1 similar proteins have N aligning to 134N 5708882_24_263 has D94 aligning to 134D 11035244_21_215 and 2 similar proteins have D aligning to 134D 11185153_25_218 has N75 aligning to 134N 3395994_38_271 has N90 aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 6003772_60_269 has D E73 Q 11228697_40_270 has D E101 Q 7665029_26_279 has D E129 Q 10266833_46_287 has D E118 Q 5646854_22_277 has D E129 Q 11023056_44_295 has D E123 Q 3500619_44_289 has D E130 Q 11202245_37_274 has D E128 Q 1261712_62_315 has N E115 E 7044010_37_278 has N E119 E 5708882_24_263 has D E117 Q 11035244_21_215 has D E97 Q 10359430_45_269 has D E108 Q 4593654_515_746 has D E105 Q 11185153_25_218 has N Q96 Q 3395994_38_271 has N E110 Q 6003772_60_269 and 13 similar proteins have E aligning to 164E 11185153_25_218 has Q96 aligning to 164Q 3395994_38_271 has E110 aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 6003772_60_269 has DE Q75 11228697_40_270 has DE Q103 7665029_26_279 has DE Q131 10266833_46_287 has DE Q120 5646854_22_277 has DE Q131 11023056_44_295 has DE Q125 3500619_44_289 has DE Q132 11202245_37_274 has DE Q130 1261712_62_315 has NE E117 7044010_37_278 has NE E121 5708882_24_263 has DE Q119 11035244_21_215 has DE Q99 10359430_45_269 has DE Q110 4593654_515_746 has DE Q107 11185153_25_218 has NQ Q98 3395994_38_271 has NE Q112 6003772_60_269 and 1 similar proteins have Q aligning to 166Q 7665029_26_279 and 1 similar proteins have Q aligning to 166Q 5646854_22_277 has Q131 aligning to 166Q 11023056_44_295 and 2 similar proteins have Q aligning to 166Q 1261712_62_315 and 1 similar proteins have E aligning to 166E 5708882_24_263 has Q119 aligning to 166Q 11035244_21_215 and 2 similar proteins have Q aligning to 166Q 11185153_25_218 has Q98 aligning to 166Q 3395994_38_271 has Q112 aligning to 166Q 0.255 0.456 0.223 0.946 6003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 6003772_60_2696003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 11228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 11228697_40_27011228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 0.935 0.954 0.194 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 7665029_26_2797665029_26_279: single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 10266833_46_28710266833_46_287: single domain, from Spirosoma linguale DSM 74 0.839 5646854_22_277: single domain, from Opitutus terrae PB90-1 5646854_22_2775646854_22_277: single domain, from Opitutus terrae PB90-1 0.882 0.165 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 11023056_44_29511023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 0.989 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c 3500619_44_2893500619_44_289: single domain, from Pseudoalteromonas atlantica T6c 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 11202245_37_27411202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 0.998 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 1261712_62_3151261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 7044010_37_278: single domain, from Caulobacter sp. K31 7044010_37_2787044010_37_278: single domain, from Caulobacter sp. K31 5708882_24_263: single domain, from Cellvibrio japonicus Ueda107 5708882_24_2635708882_24_263: single domain, from Cellvibrio japonicus Ueda107 0.840 11035244_21_215: single domain, from Niastella koreensis GR20-10, DSM 17620 11035244_21_21511035244_21_215: single domain, from Niastella koreensis GR20-10, DSM 17620 0.896 10359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 10359430_45_26910359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 4593654_515_746: with redox domain, from Planctomyces maris DSM 8797 4593654_515_7464593654_515_746: with redox domain, from Planctomyces maris DSM 8797 11185153_25_218: single domain, from Ornithobacterium rhinotracheale DSM 15997 11185153_25_21811185153_25_218: single domain, from Ornithobacterium rhinotracheale DSM 15997 3395994_38_271: single domain, from Novosphingobium aromaticivorans DSM 12444 3395994_38_2713395994_38_271: single domain, from Novosphingobium aromaticivorans DSM 12444 6003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has DEQ)6003772_60_269 with redox domain, from Verrucomicrobium spinosum DSM 4136 11228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has DEQ)11228697_40_270 single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 (has DEQ)7665029_26_279 single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 (has DEQ)10266833_46_287 single domain, from Spirosoma linguale DSM 74 5646854_22_277: single domain, from Opitutus terrae PB90-1 (has DEQ)5646854_22_277 single domain, from Opitutus terrae PB90-1 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 (has DEQ)11023056_44_295 single domain, from Cellulophaga algicola IC166, DSM 14237 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c (has DEQ)3500619_44_289 single domain, from Pseudoalteromonas atlantica T6c 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 (has DEQ)11202245_37_274 single domain, from Cytophaga fermentans IAM 14302, DSM 9555 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEE)1261712_62_315 single domain, from Novosphingobium aromaticivorans DSM 12444 7044010_37_278: single domain, from Caulobacter sp. K31 (has NEE)7044010_37_278 single domain, from Caulobacter sp. K31 5708882_24_263: single domain, from Cellvibrio japonicus Ueda107 (has DEQ)5708882_24_263 single domain, from Cellvibrio japonicus Ueda107 11035244_21_215: single domain, from Niastella koreensis GR20-10, DSM 17620 (has DEQ)11035244_21_215 single domain, from Niastella koreensis GR20-10, DSM 17620 10359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 (has DEQ)10359430_45_269 single domain, from Coraliomargarita akajimensis DSM 45221 4593654_515_746: with redox domain, from Planctomyces maris DSM 8797 (has DEQ)4593654_515_746 with redox domain, from Planctomyces maris DSM 8797 11185153_25_218: single domain, from Ornithobacterium rhinotracheale DSM 15997 (has NQQ)11185153_25_218 single domain, from Ornithobacterium rhinotracheale DSM 15997 3395994_38_271: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEQ)3395994_38_271 single domain, from Novosphingobium aromaticivorans DSM 12444 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory