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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has DEQ) 11228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has DEQ) BT2157 has N at position 134 (alignment position 385)N134 6003772_60_269 has D50 EQ 11228697_40_270 has D78 EQ 6003772_60_269 and 1 similar proteins have D aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 6003772_60_269 has D E73 Q 11228697_40_270 has D E101 Q 6003772_60_269 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 6003772_60_269 has DE Q75 11228697_40_270 has DE Q103 6003772_60_269 and 1 similar proteins have Q aligning to 166Q 6003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 6003772_60_2696003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 11228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 11228697_40_27011228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 6003772_60_269: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has DEQ)6003772_60_269 with redox domain, from Verrucomicrobium spinosum DSM 4136 11228697_40_270: single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 (has DEQ)11228697_40_270 single domain, near sugar dehydrogenase, from Cyclobacterium marinum DSM 745 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory