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Zoomed into a clade of 9 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

7665029_26_279: single domain, from Hirschia baltica ATCC 49814 (has DEQ) 10266833_46_287: single domain, from Spirosoma linguale DSM 74 (has DEQ) 5646854_22_277: single domain, from Opitutus terrae PB90-1 (has DEQ) 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 (has DEQ) 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c (has DEQ) 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 (has DEQ) 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEE) 7044010_37_278: single domain, from Caulobacter sp. K31 (has NEE) 5708882_24_263: single domain, from Cellvibrio japonicus Ueda107 (has DEQ) BT2157 has N at position 134 (alignment position 385)N134 7665029_26_279 has D105 EQ 10266833_46_287 has D96 EQ 5646854_22_277 has D106 EQ 11023056_44_295 has D100 EQ 3500619_44_289 has D107 EQ 11202245_37_274 has D105 EQ 1261712_62_315 has N92 EE 7044010_37_278 has N96 EE 5708882_24_263 has D94 EQ 7665029_26_279 and 1 similar proteins have D aligning to 134D 5646854_22_277 has D106 aligning to 134D 11023056_44_295 and 2 similar proteins have D aligning to 134D 1261712_62_315 and 1 similar proteins have N aligning to 134N 5708882_24_263 has D94 aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 7665029_26_279 has D E129 Q 10266833_46_287 has D E118 Q 5646854_22_277 has D E129 Q 11023056_44_295 has D E123 Q 3500619_44_289 has D E130 Q 11202245_37_274 has D E128 Q 1261712_62_315 has N E115 E 7044010_37_278 has N E119 E 5708882_24_263 has D E117 Q 7665029_26_279 and 8 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 7665029_26_279 has DE Q131 10266833_46_287 has DE Q120 5646854_22_277 has DE Q131 11023056_44_295 has DE Q125 3500619_44_289 has DE Q132 11202245_37_274 has DE Q130 1261712_62_315 has NE E117 7044010_37_278 has NE E121 5708882_24_263 has DE Q119 7665029_26_279 and 1 similar proteins have Q aligning to 166Q 5646854_22_277 has Q131 aligning to 166Q 11023056_44_295 and 2 similar proteins have Q aligning to 166Q 1261712_62_315 and 1 similar proteins have E aligning to 166E 5708882_24_263 has Q119 aligning to 166Q 0.954 0.194 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 7665029_26_2797665029_26_279: single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 10266833_46_28710266833_46_287: single domain, from Spirosoma linguale DSM 74 0.839 5646854_22_277: single domain, from Opitutus terrae PB90-1 5646854_22_2775646854_22_277: single domain, from Opitutus terrae PB90-1 0.882 0.165 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 11023056_44_29511023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 0.989 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c 3500619_44_2893500619_44_289: single domain, from Pseudoalteromonas atlantica T6c 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 11202245_37_27411202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 0.998 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 1261712_62_3151261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 7044010_37_278: single domain, from Caulobacter sp. K31 7044010_37_2787044010_37_278: single domain, from Caulobacter sp. K31 5708882_24_263: single domain, from Cellvibrio japonicus Ueda107 5708882_24_2635708882_24_263: single domain, from Cellvibrio japonicus Ueda107 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 (has DEQ)7665029_26_279 single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 (has DEQ)10266833_46_287 single domain, from Spirosoma linguale DSM 74 5646854_22_277: single domain, from Opitutus terrae PB90-1 (has DEQ)5646854_22_277 single domain, from Opitutus terrae PB90-1 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 (has DEQ)11023056_44_295 single domain, from Cellulophaga algicola IC166, DSM 14237 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c (has DEQ)3500619_44_289 single domain, from Pseudoalteromonas atlantica T6c 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 (has DEQ)11202245_37_274 single domain, from Cytophaga fermentans IAM 14302, DSM 9555 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEE)1261712_62_315 single domain, from Novosphingobium aromaticivorans DSM 12444 7044010_37_278: single domain, from Caulobacter sp. K31 (has NEE)7044010_37_278 single domain, from Caulobacter sp. K31 5708882_24_263: single domain, from Cellvibrio japonicus Ueda107 (has DEQ)5708882_24_263 single domain, from Cellvibrio japonicus Ueda107 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory