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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

7665029_26_279: single domain, from Hirschia baltica ATCC 49814 (has DEQ) 10266833_46_287: single domain, from Spirosoma linguale DSM 74 (has DEQ) BT2157 has N at position 134 (alignment position 385)N134 7665029_26_279 has D105 EQ 10266833_46_287 has D96 EQ 7665029_26_279 and 1 similar proteins have D aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 7665029_26_279 has D E129 Q 10266833_46_287 has D E118 Q 7665029_26_279 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 7665029_26_279 has DE Q131 10266833_46_287 has DE Q120 7665029_26_279 and 1 similar proteins have Q aligning to 166Q 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 7665029_26_2797665029_26_279: single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 10266833_46_28710266833_46_287: single domain, from Spirosoma linguale DSM 74 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 (has DEQ)7665029_26_279 single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 (has DEQ)10266833_46_287 single domain, from Spirosoma linguale DSM 74 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory