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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.194 7665029_26_279: single domain, from Hirschia baltica ATCC 49814 10266833_46_287: single domain, from Spirosoma linguale DSM 74 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Hirschia baltica ATCC 49814 7665029_26_279 single domain, from Hirschia baltica ATCC 49814 7665029_26_279 at #155: Q1 7665029_26_279 at #155: Q1 Q 7665029_26_279 at #156: W2 7665029_26_279 at #156: W2 W 7665029_26_279 at #157: T3 7665029_26_279 at #157: T3 T 7665029_26_279 at #158: P4 7665029_26_279 at #158: P4 P 7665029_26_279 at #159: L5 7665029_26_279 at #159: L5 L 7665029_26_279 at #160: L6 7665029_26_279 at #160: L6 L 7665029_26_279 at #162: D7 7665029_26_279 at #162: D7 D 7665029_26_279 at #164 7665029_26_279 at #164 - 7665029_26_279 at #165: E8 7665029_26_279 at #165: E8 E 7665029_26_279 at #168: D9 7665029_26_279 at #168: D9 D 7665029_26_279 at #169: L10 7665029_26_279 at #169: L10 L 7665029_26_279 at #171: S11 7665029_26_279 at #171: S11 S 7665029_26_279 at #172: Q12 7665029_26_279 at #172: Q12 Q 7665029_26_279 at #180: W13 7665029_26_279 at #180: W13 W 7665029_26_279 at #181: D14 7665029_26_279 at #181: D14 D 7665029_26_279 at #185: I15 7665029_26_279 at #185: I15 I 7665029_26_279 at #186: Y16 7665029_26_279 at #186: Y16 Y 7665029_26_279 at #187: L17 7665029_26_279 at #187: L17 L 7665029_26_279 at #188: S18 7665029_26_279 at #188: S18 S 7665029_26_279 at #189: Y19 7665029_26_279 at #189: Y19 Y 7665029_26_279 at #190: R20 7665029_26_279 at #190: R20 R 7665029_26_279 at #191: H21 7665029_26_279 at #191: H21 H 7665029_26_279 at #195: Q22 7665029_26_279 at #195: Q22 Q 7665029_26_279 at #196: Y23 7665029_26_279 at #196: Y23 Y 7665029_26_279 at #197: G24 7665029_26_279 at #197: G24 G 7665029_26_279 at #198: Y25 7665029_26_279 at #198: Y25 Y 7665029_26_279 at #235: I56 7665029_26_279 at #235: I56 I 7665029_26_279 at #236: V57 7665029_26_279 at #236: V57 V 7665029_26_279 at #237: K58 7665029_26_279 at #237: K58 K 7665029_26_279 at #238: D59 7665029_26_279 at #238: D59 D 7665029_26_279 at #240: G60 7665029_26_279 at #240: G60 G 7665029_26_279 at #268: E61 7665029_26_279 at #268: E61 E 7665029_26_279 at #269: P62 7665029_26_279 at #269: P62 P 7665029_26_279 at #270: V63 7665029_26_279 at #270: V63 V 7665029_26_279 at #294: R65 7665029_26_279 at #294: R65 R 7665029_26_279 at #295: V66 7665029_26_279 at #295: V66 V 7665029_26_279 at #296: S67 7665029_26_279 at #296: S67 S 7665029_26_279 at #297: G68 7665029_26_279 at #297: G68 G 7665029_26_279 at #298: E69 7665029_26_279 at #298: E69 E 7665029_26_279 at #299: A70 7665029_26_279 at #299: A70 A 7665029_26_279 at #300: Y71 7665029_26_279 at #300: Y71 Y 7665029_26_279 at #301: G72 7665029_26_279 at #301: G72 G 7665029_26_279 at #303: A73 7665029_26_279 at #303: A73 A 7665029_26_279 at #304: V74 7665029_26_279 at #304: V74 V 7665029_26_279 at #305: I75 7665029_26_279 at #305: I75 I 7665029_26_279 at #306: S76 7665029_26_279 at #306: S76 S 7665029_26_279 at #312: K77 7665029_26_279 at #312: K77 K 7665029_26_279 at #318: K78 7665029_26_279 at #318: K78 K 7665029_26_279 at #321: E79 7665029_26_279 at #321: E79 E 7665029_26_279 at #322: Y80 7665029_26_279 at #322: Y80 Y 7665029_26_279 at #324: R81 7665029_26_279 at #324: R81 R 7665029_26_279 at #326: N82 7665029_26_279 at #326: N82 N 7665029_26_279 at #327: Y83 7665029_26_279 at #327: Y83 Y 7665029_26_279 at #328: R84 7665029_26_279 at #328: R84 R 7665029_26_279 at #329: L85 7665029_26_279 at #329: L85 L 7665029_26_279 at #330: K86 7665029_26_279 at #330: K86 K 7665029_26_279 at #331: L87 7665029_26_279 at #331: L87 L 7665029_26_279 at #332: K88 7665029_26_279 at #332: K88 K 7665029_26_279 at #333: V89 7665029_26_279 at #333: V89 V 7665029_26_279 at #334: K90 7665029_26_279 at #334: K90 K 7665029_26_279 at #335: W91 7665029_26_279 at #335: W91 W 7665029_26_279 at #351: P97 7665029_26_279 at #351: P97 P 7665029_26_279 at #352: P98 7665029_26_279 at #352: P98 P 7665029_26_279 at #354: R99 7665029_26_279 at #354: R99 R 7665029_26_279 at #355: E100 7665029_26_279 at #355: E100 E 7665029_26_279 at #385: D105 7665029_26_279 at #385: D105 D 7665029_26_279 at #386: S106 7665029_26_279 at #386: S106 S 7665029_26_279 at #387: G107 7665029_26_279 at #387: G107 G 7665029_26_279 at #388: I108 7665029_26_279 at #388: I108 I 7665029_26_279 at #389: L109 7665029_26_279 at #389: L109 L 7665029_26_279 at #390: Y110 7665029_26_279 at #390: Y110 Y 7665029_26_279 at #391: H111 7665029_26_279 at #391: H111 H 7665029_26_279 at #392: S112 7665029_26_279 at #392: S112 S 7665029_26_279 at #393: I113 7665029_26_279 at #393: I113 I 7665029_26_279 at #423: A118 7665029_26_279 at #423: A118 A 7665029_26_279 at #424: D119 7665029_26_279 at #424: D119 D 7665029_26_279 at #425: H120 7665029_26_279 at #425: H120 H 7665029_26_279 at #426: W121 7665029_26_279 at #426: W121 W 7665029_26_279 at #430: R122 7665029_26_279 at #430: R122 R 7665029_26_279 at #431: S123 7665029_26_279 at #431: S123 S 7665029_26_279 at #432: W124 7665029_26_279 at #432: W124 W 7665029_26_279 at #433: M125 7665029_26_279 at #433: M125 M 7665029_26_279 at #434: L126 7665029_26_279 at #434: L126 L 7665029_26_279 at #435: S127 7665029_26_279 at #435: S127 S 7665029_26_279 at #436: Q128 7665029_26_279 at #436: Q128 Q 7665029_26_279 at #438: E129 7665029_26_279 at #438: E129 E 7665029_26_279 at #439: F130 7665029_26_279 at #439: F130 F 7665029_26_279 at #440: Q131 7665029_26_279 at #440: Q131 Q 7665029_26_279 at #441: I132 7665029_26_279 at #441: I132 I 7665029_26_279 at #442: M133 7665029_26_279 at #442: M133 M 7665029_26_279 at #443: Q134 7665029_26_279 at #443: Q134 Q 7665029_26_279 at #450: G135 7665029_26_279 at #450: G135 G 7665029_26_279 at #451: H136 7665029_26_279 at #451: H136 H 7665029_26_279 at #452: M137 7665029_26_279 at #452: M137 M 7665029_26_279 at #453: G138 7665029_26_279 at #453: G138 G 7665029_26_279 at #475 7665029_26_279 at #475 - 7665029_26_279 at #476: D139 7665029_26_279 at #476: D139 D 7665029_26_279 at #477: F140 7665029_26_279 at #477: F140 F 7665029_26_279 at #478: W141 7665029_26_279 at #478: W141 W 7665029_26_279 at #479: N142 7665029_26_279 at #479: N142 N 7665029_26_279 at #480: Q143 7665029_26_279 at #480: Q143 Q 7665029_26_279 at #481: A144 7665029_26_279 at #481: A144 A 7665029_26_279 at #482: N145 7665029_26_279 at #482: N145 N 7665029_26_279 at #483: S146 7665029_26_279 at #483: S146 S 7665029_26_279 at #484: A147 7665029_26_279 at #484: A147 A 7665029_26_279 at #485: I148 7665029_26_279 at #485: I148 I 7665029_26_279 at #486: D149 7665029_26_279 at #486: D149 D 7665029_26_279 at #487: I150 7665029_26_279 at #487: I150 I 7665029_26_279 at #530: I178 7665029_26_279 at #530: I178 I 7665029_26_279 at #532: G180 7665029_26_279 at #532: G180 G 7665029_26_279 at #533: F181 7665029_26_279 at #533: F181 F 7665029_26_279 at #534: V182 7665029_26_279 at #534: V182 V 7665029_26_279 at #535: L183 7665029_26_279 at #535: L183 L 7665029_26_279 at #544: R184 7665029_26_279 at #544: R184 R 7665029_26_279 at #545: K185 7665029_26_279 at #545: K185 K 7665029_26_279 at #548: E186 7665029_26_279 at #548: E186 E 7665029_26_279 at #549: N187 7665029_26_279 at #549: N187 N 7665029_26_279 at #550: H188 7665029_26_279 at #550: H188 H 7665029_26_279 at #551: E189 7665029_26_279 at #551: E189 E 7665029_26_279 at #552: N190 7665029_26_279 at #552: N190 N 7665029_26_279 at #553: P191 7665029_26_279 at #553: P191 P 7665029_26_279 at #554: H192 7665029_26_279 at #554: H192 H 7665029_26_279 at #555: G193 7665029_26_279 at #555: G193 G 7665029_26_279 at #556: Q194 7665029_26_279 at #556: Q194 Q 7665029_26_279 at #557: W195 7665029_26_279 at #557: W195 W 7665029_26_279 at #558: N196 7665029_26_279 at #558: N196 N 7665029_26_279 at #559: E197 7665029_26_279 at #559: E197 E 7665029_26_279 at #560: L198 7665029_26_279 at #560: L198 L 7665029_26_279 at #561: E199 7665029_26_279 at #561: E199 E 7665029_26_279 at #562: L200 7665029_26_279 at #562: L200 L 7665029_26_279 at #565: I201 7665029_26_279 at #565: I201 I 7665029_26_279 at #566: C202 7665029_26_279 at #566: C202 C 7665029_26_279 at #568: H203 7665029_26_279 at #568: H203 H 7665029_26_279 at #570: E204 7665029_26_279 at #570: E204 E 7665029_26_279 at #571: G205 7665029_26_279 at #571: G205 G 7665029_26_279 at #572: R206 7665029_26_279 at #572: R206 R 7665029_26_279 at #588: S207 7665029_26_279 at #588: S207 S 7665029_26_279 at #589: L208 7665029_26_279 at #589: L208 L 7665029_26_279 at #592: H209 7665029_26_279 at #592: H209 H 7665029_26_279 at #594: I210 7665029_26_279 at #594: I210 I 7665029_26_279 at #595: V211 7665029_26_279 at #595: V211 V 7665029_26_279 at #596: N212 7665029_26_279 at #596: N212 N 7665029_26_279 at #598: G213 7665029_26_279 at #598: G213 G 7665029_26_279 at #599: H214 7665029_26_279 at #599: H214 H 7665029_26_279 at #600: V215 7665029_26_279 at #600: V215 V 7665029_26_279 at #601: V216 7665029_26_279 at #601: V216 V 7665029_26_279 at #602: M217 7665029_26_279 at #602: M217 M 7665029_26_279 at #603: A218 7665029_26_279 at #603: A218 A 7665029_26_279 at #604: L219 7665029_26_279 at #604: L219 L 7665029_26_279 at #605: Q220 7665029_26_279 at #605: Q220 Q 7665029_26_279 at #606: N221 7665029_26_279 at #606: N221 N 7665029_26_279 at #607: S222 7665029_26_279 at #607: S222 S 7665029_26_279 at #608: R223 7665029_26_279 at #608: R223 R 7665029_26_279 at #609: Y224 7665029_26_279 at #609: Y224 Y 7665029_26_279 at #610: I225 7665029_26_279 at #610: I225 I 7665029_26_279 at #611: E226 7665029_26_279 at #611: E226 E 7665029_26_279 at #612: N227 7665029_26_279 at #612: N227 N 7665029_26_279 at #613: G228 7665029_26_279 at #613: G228 G 7665029_26_279 at #614: E229 7665029_26_279 at #614: E229 E 7665029_26_279 at #615: A230 7665029_26_279 at #615: A230 A 7665029_26_279 at #616: I231 7665029_26_279 at #616: I231 I 7665029_26_279 at #640 7665029_26_279 at #640 - 7665029_26_279 at #641: D232 7665029_26_279 at #641: D232 D 7665029_26_279 at #642: L233 7665029_26_279 at #642: L233 L 7665029_26_279 at #643: Y234 7665029_26_279 at #643: Y234 Y 7665029_26_279 at #644: E235 7665029_26_279 at #644: E235 E 7665029_26_279 at #645: G236 7665029_26_279 at #645: G236 G 7665029_26_279 at #646: K237 7665029_26_279 at #646: K237 K 7665029_26_279 at #647: I238 7665029_26_279 at #647: I238 I 7665029_26_279 at #648: Q239 7665029_26_279 at #648: Q239 Q 7665029_26_279 at #649: L240 7665029_26_279 at #649: L240 L 7665029_26_279 at #650: Q241 7665029_26_279 at #650: Q241 Q 7665029_26_279 at #653: S242 7665029_26_279 at #653: S242 S 7665029_26_279 at #654: E243 7665029_26_279 at #654: E243 E 7665029_26_279 at #655: A244 7665029_26_279 at #655: A244 A 7665029_26_279 at #668: A245 7665029_26_279 at #668: A245 A 7665029_26_279 at #689: E246 7665029_26_279 at #689: E246 E 7665029_26_279 at #690: L247 7665029_26_279 at #690: L247 L 7665029_26_279 at #691: F248 7665029_26_279 at #691: F248 F 7665029_26_279 at #694: Y249 7665029_26_279 at #694: Y249 Y 7665029_26_279 at #695: K250 7665029_26_279 at #695: K250 K 7665029_26_279 at #696: D251 7665029_26_279 at #696: D251 D 7665029_26_279 at #697: I252 7665029_26_279 at #697: I252 I 7665029_26_279 at #698: E253 7665029_26_279 at #698: E253 E 7665029_26_279 at #699: I254 7665029_26_279 at #699: I254 I 7665029_26_279 at #700 7665029_26_279 at #700 - single domain, from Spirosoma linguale DSM 74 10266833_46_287 single domain, from Spirosoma linguale DSM 74 10266833_46_287 at #155: K1 10266833_46_287 at #155: K1 K 10266833_46_287 at #156: W2 10266833_46_287 at #156: W2 W 10266833_46_287 at #157: Q3 10266833_46_287 at #157: Q3 Q 10266833_46_287 at #158: S4 10266833_46_287 at #158: S4 S 10266833_46_287 at #159: L5 10266833_46_287 at #159: L5 L 10266833_46_287 at #160: F6 10266833_46_287 at #160: F6 F 10266833_46_287 at #162: N7 10266833_46_287 at #162: N7 N 10266833_46_287 at #164: G8 10266833_46_287 at #164: G8 G 10266833_46_287 at #165: K9 10266833_46_287 at #165: K9 K 10266833_46_287 at #168: N10 10266833_46_287 at #168: N10 N 10266833_46_287 at #169: L11 10266833_46_287 at #169: L11 L 10266833_46_287 at #171: S12 10266833_46_287 at #171: S12 S 10266833_46_287 at #172: G13 10266833_46_287 at #172: G13 G 10266833_46_287 at #180: W14 10266833_46_287 at #180: W14 W 10266833_46_287 at #181: E15 10266833_46_287 at #181: E15 E 10266833_46_287 at #185: T16 10266833_46_287 at #185: T16 T 10266833_46_287 at #186: Y17 10266833_46_287 at #186: Y17 Y 10266833_46_287 at #187: L18 10266833_46_287 at #187: L18 L 10266833_46_287 at #188: D19 10266833_46_287 at #188: D19 D 10266833_46_287 at #189: K20 10266833_46_287 at #189: K20 K 10266833_46_287 at #190: P21 10266833_46_287 at #190: P21 P 10266833_46_287 at #191: Y22 10266833_46_287 at #191: Y22 Y 10266833_46_287 at #195: A23 10266833_46_287 at #195: A23 A 10266833_46_287 at #196 10266833_46_287 at #196 - 10266833_46_287 at #197 10266833_46_287 at #197 - 10266833_46_287 at #198: K24 10266833_46_287 at #198: K24 K 10266833_46_287 at #235: V47 10266833_46_287 at #235: V47 V 10266833_46_287 at #236: T48 10266833_46_287 at #236: T48 T 10266833_46_287 at #237: V49 10266833_46_287 at #237: V49 V 10266833_46_287 at #238: D50 10266833_46_287 at #238: D50 D 10266833_46_287 at #240: G51 10266833_46_287 at #240: G51 G 10266833_46_287 at #268: K52 10266833_46_287 at #268: K52 K 10266833_46_287 at #269: P53 10266833_46_287 at #269: P53 P 10266833_46_287 at #270: A54 10266833_46_287 at #270: A54 A 10266833_46_287 at #294: R56 10266833_46_287 at #294: R56 R 10266833_46_287 at #295: I57 10266833_46_287 at #295: I57 I 10266833_46_287 at #296: S58 10266833_46_287 at #296: S58 S 10266833_46_287 at #297: G59 10266833_46_287 at 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory