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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 (has DEQ) 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c (has DEQ) 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 (has DEQ) BT2157 has N at position 134 (alignment position 385)N134 11023056_44_295 has D100 EQ 3500619_44_289 has D107 EQ 11202245_37_274 has D105 EQ 11023056_44_295 and 2 similar proteins have D aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 11023056_44_295 has D E123 Q 3500619_44_289 has D E130 Q 11202245_37_274 has D E128 Q 11023056_44_295 and 2 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11023056_44_295 has DE Q125 3500619_44_289 has DE Q132 11202245_37_274 has DE Q130 11023056_44_295 and 2 similar proteins have Q aligning to 166Q 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 11023056_44_29511023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 0.989 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c 3500619_44_2893500619_44_289: single domain, from Pseudoalteromonas atlantica T6c 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 11202245_37_27411202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 11023056_44_295: single domain, from Cellulophaga algicola IC166, DSM 14237 (has DEQ)11023056_44_295 single domain, from Cellulophaga algicola IC166, DSM 14237 3500619_44_289: single domain, from Pseudoalteromonas atlantica T6c (has DEQ)3500619_44_289 single domain, from Pseudoalteromonas atlantica T6c 11202245_37_274: single domain, from Cytophaga fermentans IAM 14302, DSM 9555 (has DEQ)11202245_37_274 single domain, from Cytophaga fermentans IAM 14302, DSM 9555 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory