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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEE) 7044010_37_278: single domain, from Caulobacter sp. K31 (has NEE) BT2157 has N at position 134 (alignment position 385)N134 1261712_62_315 has N92 EE 7044010_37_278 has N96 EE 1261712_62_315 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 1261712_62_315 has N E115 E 7044010_37_278 has N E119 E 1261712_62_315 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 1261712_62_315 has NE E117 7044010_37_278 has NE E121 1261712_62_315 and 1 similar proteins have E aligning to 166E 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 1261712_62_3151261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 7044010_37_278: single domain, from Caulobacter sp. K31 7044010_37_2787044010_37_278: single domain, from Caulobacter sp. K31 1261712_62_315: single domain, from Novosphingobium aromaticivorans DSM 12444 (has NEE)1261712_62_315 single domain, from Novosphingobium aromaticivorans DSM 12444 7044010_37_278: single domain, from Caulobacter sp. K31 (has NEE)7044010_37_278 single domain, from Caulobacter sp. K31 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory