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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 (has DEQ) 4593654_515_746: with redox domain, from Planctomyces maris DSM 8797 (has DEQ) BT2157 has N at position 134 (alignment position 385)N134 10359430_45_269 has D90 EQ 4593654_515_746 has D86 EQ 10359430_45_269 and 1 similar proteins have D aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 10359430_45_269 has D E108 Q 4593654_515_746 has D E105 Q 10359430_45_269 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 10359430_45_269 has DE Q110 4593654_515_746 has DE Q107 10359430_45_269 and 1 similar proteins have Q aligning to 166Q 10359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 10359430_45_26910359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 4593654_515_746: with redox domain, from Planctomyces maris DSM 8797 4593654_515_7464593654_515_746: with redox domain, from Planctomyces maris DSM 8797 10359430_45_269: single domain, from Coraliomargarita akajimensis DSM 45221 (has DEQ)10359430_45_269 single domain, from Coraliomargarita akajimensis DSM 45221 4593654_515_746: with redox domain, from Planctomyces maris DSM 8797 (has DEQ)4593654_515_746 with redox domain, from Planctomyces maris DSM 8797 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory