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Zoomed into a clade of 7 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10981894_25_253: single domain, from Leadbetterella byssophila 4M15, DSM 17132 (has NEQ) 5848961_43_276: single domain, from Caulobacter crescentus NA1000 (has NEQ) 7094637_39_268: single domain, from Sphingomonas wittichii RW1 (has NEQ) 11295415_26_253: single domain, from Planctomyces brasiliensis DSM 5305 (has NEQ) 7399905_41_280: single domain, from Dyadobacter fermentans DSM 18053 (has NEQ) 2712523_30_259: single domain, from Tenacibaculum sp. MED152 (has NEQ) 2766517_33_261: single domain, from Flavobacteriales bacterium HTCC2170 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 10981894_25_253 has N85 EQ 5848961_43_276 has N87 EQ 7094637_39_268 has N86 EQ 11295415_26_253 has N86 EQ 7399905_41_280 has N87 EQ 2712523_30_259 has N87 EQ 2766517_33_261 has N87 EQ 10981894_25_253 and 6 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 10981894_25_253 has N E109 Q 5848961_43_276 has N E111 Q 7094637_39_268 has N E110 Q 11295415_26_253 has N E110 Q 7399905_41_280 has N E111 Q 2712523_30_259 has N E111 Q 2766517_33_261 has N E111 Q 10981894_25_253 and 6 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 10981894_25_253 has NE Q111 5848961_43_276 has NE Q113 7094637_39_268 has NE Q112 11295415_26_253 has NE Q112 7399905_41_280 has NE Q113 2712523_30_259 has NE Q113 2766517_33_261 has NE Q113 10981894_25_253 and 6 similar proteins have Q aligning to 166Q 10981894_25_253: single domain, from Leadbetterella byssophila 4M15, DSM 17132 10981894_25_25310981894_25_253: single domain, from Leadbetterella byssophila 4M15, DSM 17132 0.882 0.974 5848961_43_276: single domain, from Caulobacter crescentus NA1000 5848961_43_2765848961_43_276: single domain, from Caulobacter crescentus NA1000 7094637_39_268: single domain, from Sphingomonas wittichii RW1 7094637_39_2687094637_39_268: single domain, from Sphingomonas wittichii RW1 0.355 11295415_26_253: single domain, from Planctomyces brasiliensis DSM 5305 11295415_26_25311295415_26_253: single domain, from Planctomyces brasiliensis DSM 5305 0.789 7399905_41_280: single domain, from Dyadobacter fermentans DSM 18053 7399905_41_2807399905_41_280: single domain, from Dyadobacter fermentans DSM 18053 0.049 2712523_30_259: single domain, from Tenacibaculum sp. MED152 2712523_30_2592712523_30_259: single domain, from Tenacibaculum sp. MED152 2766517_33_261: single domain, from Flavobacteriales bacterium HTCC2170 2766517_33_2612766517_33_261: single domain, from Flavobacteriales bacterium HTCC2170 10981894_25_253: single domain, from Leadbetterella byssophila 4M15, DSM 17132 (has NEQ)10981894_25_253 single domain, from Leadbetterella byssophila 4M15, DSM 17132 5848961_43_276: single domain, from Caulobacter crescentus NA1000 (has NEQ)5848961_43_276 single domain, from Caulobacter crescentus NA1000 7094637_39_268: single domain, from Sphingomonas wittichii RW1 (has NEQ)7094637_39_268 single domain, from Sphingomonas wittichii RW1 11295415_26_253: single domain, from Planctomyces brasiliensis DSM 5305 (has NEQ)11295415_26_253 single domain, from Planctomyces brasiliensis DSM 5305 7399905_41_280: single domain, from Dyadobacter fermentans DSM 18053 (has NEQ)7399905_41_280 single domain, from Dyadobacter fermentans DSM 18053 2712523_30_259: single domain, from Tenacibaculum sp. MED152 (has NEQ)2712523_30_259 single domain, from Tenacibaculum sp. MED152 2766517_33_261: single domain, from Flavobacteriales bacterium HTCC2170 (has NEQ)2766517_33_261 single domain, from Flavobacteriales bacterium HTCC2170 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory