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Zoomed into a clade of 6 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11000386_925_1125: with other domain, near sugar dehydrogenase, from Alistipes finegoldii AHN 2437, DSM 17242 (has NEQ) 4595173_477_662: with other domain, from Planctomyces maris DSM 8797 (has NEQ) 4614159_29_215: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has NEQ) 4909469_250_435: tandem domain, from Gemmata obscuriglobus UQM 2246 (has NEQ) 6005680_33_220: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ) 10306114_33_218: single domain, from Pirellula staleyi DSM 6068 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11000386_925_1125 has N63 EQ 4595173_477_662 has N62 EQ 4614159_29_215 has N60 EQ 4909469_250_435 has N60 EQ 6005680_33_220 has N60 EQ 10306114_33_218 has N60 EQ 11000386_925_1125 and 5 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11000386_925_1125 has N E82 Q 4595173_477_662 has N E82 Q 4614159_29_215 has N E86 Q 4909469_250_435 has N E81 Q 6005680_33_220 has N E84 Q 10306114_33_218 has N E79 Q 11000386_925_1125 and 5 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11000386_925_1125 has NE Q84 4595173_477_662 has NE Q84 4614159_29_215 has NE Q88 4909469_250_435 has NE Q83 6005680_33_220 has NE Q86 10306114_33_218 has NE Q81 11000386_925_1125 and 5 similar proteins have Q aligning to 166Q 11000386_925_1125: with other domain, near sugar dehydrogenase, from Alistipes finegoldii AHN 2437, DSM 17242 11000386_925_112511000386_925_1125: with other domain, near sugar dehydrogenase, from Alistipes finegoldii AHN 2437, DSM 17242 0.306 4595173_477_662: with other domain, from Planctomyces maris DSM 8797 4595173_477_6624595173_477_662: with other domain, from Planctomyces maris DSM 8797 0.787 0.971 4614159_29_215: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_29_2154614159_29_215: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4909469_250_435: tandem domain, from Gemmata obscuriglobus UQM 2246 4909469_250_4354909469_250_435: tandem domain, from Gemmata obscuriglobus UQM 2246 0.653 6005680_33_220: single domain, from Verrucomicrobium spinosum DSM 4136 6005680_33_2206005680_33_220: single domain, from Verrucomicrobium spinosum DSM 4136 10306114_33_218: single domain, from Pirellula staleyi DSM 6068 10306114_33_21810306114_33_218: single domain, from Pirellula staleyi DSM 6068 11000386_925_1125: with other domain, near sugar dehydrogenase, from Alistipes finegoldii AHN 2437, DSM 17242 (has NEQ)11000386_925_1125 with other domain, near sugar dehydrogenase, from Alistipes finegoldii AHN 2437, DSM 17242 4595173_477_662: with other domain, from Planctomyces maris DSM 8797 (has NEQ)4595173_477_662 with other domain, from Planctomyces maris DSM 8797 4614159_29_215: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has NEQ)4614159_29_215 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4909469_250_435: tandem domain, from Gemmata obscuriglobus UQM 2246 (has NEQ)4909469_250_435 tandem domain, from Gemmata obscuriglobus UQM 2246 6005680_33_220: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ)6005680_33_220 single domain, from Verrucomicrobium spinosum DSM 4136 10306114_33_218: single domain, from Pirellula staleyi DSM 6068 (has NEQ)10306114_33_218 single domain, from Pirellula staleyi DSM 6068 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory