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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.971 4614159_29_215: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4909469_250_435: tandem domain, from Gemmata obscuriglobus UQM 2246 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_29_215 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_29_215 at #155 4614159_29_215 at #155 - 4614159_29_215 at #156: F1 4614159_29_215 at #156: F1 F 4614159_29_215 at #157: T2 4614159_29_215 at #157: T2 T 4614159_29_215 at #158: S3 4614159_29_215 at #158: S3 S 4614159_29_215 at #159: L4 4614159_29_215 at #159: L4 L 4614159_29_215 at #160: F5 4614159_29_215 at #160: F5 F 4614159_29_215 at #162: E6 4614159_29_215 at #162: E6 E 4614159_29_215 at #164: D8 4614159_29_215 at #164: D8 D 4614159_29_215 at #165: A9 4614159_29_215 at #165: A9 A 4614159_29_215 at #168: D10 4614159_29_215 at #168: D10 D 4614159_29_215 at #169: L11 4614159_29_215 at #169: L11 L 4614159_29_215 at #171: T13 4614159_29_215 at #171: T13 T 4614159_29_215 at #172: N14 4614159_29_215 at #172: N14 N 4614159_29_215 at #180: W15 4614159_29_215 at #180: W15 W 4614159_29_215 at #181: I16 4614159_29_215 at #181: I16 I 4614159_29_215 at #185: G17 4614159_29_215 at #185: G17 G 4614159_29_215 at #186: N18 4614159_29_215 at #186: N18 N 4614159_29_215 at #187: T19 4614159_29_215 at #187: T19 T 4614159_29_215 at #188: Q20 4614159_29_215 at #188: Q20 Q 4614159_29_215 at #189: G21 4614159_29_215 at #189: G21 G 4614159_29_215 at #190 4614159_29_215 at #190 - 4614159_29_215 at #191 4614159_29_215 at #191 - 4614159_29_215 at #195 4614159_29_215 at #195 - 4614159_29_215 at #196 4614159_29_215 at #196 - 4614159_29_215 at #197 4614159_29_215 at #197 - 4614159_29_215 at #198: Y22 4614159_29_215 at #198: Y22 Y 4614159_29_215 at #235: K23 4614159_29_215 at #235: K23 K 4614159_29_215 at #236: V24 4614159_29_215 at #236: V24 V 4614159_29_215 at #237: E25 4614159_29_215 at #237: E25 E 4614159_29_215 at #238: N26 4614159_29_215 at #238: N26 N 4614159_29_215 at #240: N27 4614159_29_215 at #240: N27 N 4614159_29_215 at #268: T28 4614159_29_215 at #268: T28 T 4614159_29_215 at #269: L29 4614159_29_215 at #269: L29 L 4614159_29_215 at #270: I30 4614159_29_215 at #270: I30 I 4614159_29_215 at #294 4614159_29_215 at #294 - 4614159_29_215 at #295 4614159_29_215 at #295 - 4614159_29_215 at #296: A31 4614159_29_215 at #296: A31 A 4614159_29_215 at #297: Q32 4614159_29_215 at #297: Q32 Q 4614159_29_215 at #298: P33 4614159_29_215 at #298: P33 P 4614159_29_215 at #299: R34 4614159_29_215 at #299: R34 R 4614159_29_215 at #300: C35 4614159_29_215 at #300: C35 C 4614159_29_215 at #301: G36 4614159_29_215 at #301: G36 G 4614159_29_215 at #303: N37 4614159_29_215 at #303: N37 N 4614159_29_215 at #304: I38 4614159_29_215 at #304: I38 I 4614159_29_215 at #305: Y39 4614159_29_215 at #305: Y39 Y 4614159_29_215 at #306: T40 4614159_29_215 at #306: T40 T 4614159_29_215 at #312: A41 4614159_29_215 at #312: A41 A 4614159_29_215 at #318: K42 4614159_29_215 at #318: K42 K 4614159_29_215 at #321: E43 4614159_29_215 at #321: E43 E 4614159_29_215 at #322: Y44 4614159_29_215 at #322: Y44 Y 4614159_29_215 at #324: Q45 4614159_29_215 at #324: Q45 Q 4614159_29_215 at #326: D46 4614159_29_215 at #326: D46 D 4614159_29_215 at #327: Y47 4614159_29_215 at #327: Y47 Y 4614159_29_215 at #328: V48 4614159_29_215 at #328: V48 V 4614159_29_215 at #329: L49 4614159_29_215 at #329: L49 L 4614159_29_215 at #330: R50 4614159_29_215 at #330: R50 R 4614159_29_215 at #331: F51 4614159_29_215 at #331: F51 F 4614159_29_215 at #332: E52 4614159_29_215 at #332: E52 E 4614159_29_215 at #333: F53 4614159_29_215 at #333: F53 F 4614159_29_215 at #334: K54 4614159_29_215 at #334: K54 K 4614159_29_215 at #335: L55 4614159_29_215 at #335: L55 L 4614159_29_215 at #351: A56 4614159_29_215 at #351: A56 A 4614159_29_215 at #352: P57 4614159_29_215 at #352: P57 P 4614159_29_215 at #354: H58 4614159_29_215 at #354: H58 H 4614159_29_215 at #355: A59 4614159_29_215 at #355: A59 A 4614159_29_215 at #385: N60 4614159_29_215 at #385: N60 N 4614159_29_215 at #386: N61 4614159_29_215 at #386: N61 N 4614159_29_215 at #387: G62 4614159_29_215 at #387: G62 G 4614159_29_215 at #388: I63 4614159_29_215 at #388: I63 I 4614159_29_215 at #389: G64 4614159_29_215 at #389: G64 G 4614159_29_215 at #390: L65 4614159_29_215 at #390: L65 L 4614159_29_215 at #391: R66 4614159_29_215 at #391: R66 R 4614159_29_215 at #392: A67 4614159_29_215 at #392: A67 A 4614159_29_215 at #393: P68 4614159_29_215 at #393: P68 P 4614159_29_215 at #423: V75 4614159_29_215 at #423: V75 V 4614159_29_215 at #424: K76 4614159_29_215 at #424: K76 K 4614159_29_215 at #425: R77 4614159_29_215 at #425: R77 R 4614159_29_215 at #426: H78 4614159_29_215 at #426: H78 H 4614159_29_215 at #430: I79 4614159_29_215 at #430: I79 I 4614159_29_215 at #431: P80 4614159_29_215 at #431: P80 P 4614159_29_215 at #432: A81 4614159_29_215 at #432: A81 A 4614159_29_215 at #433: Y82 4614159_29_215 at #433: Y82 Y 4614159_29_215 at #434: S83 4614159_29_215 at #434: S83 S 4614159_29_215 at #435: T84 4614159_29_215 at #435: T84 T 4614159_29_215 at #436: V85 4614159_29_215 at #436: V85 V 4614159_29_215 at #438: E86 4614159_29_215 at #438: E86 E 4614159_29_215 at #439: I87 4614159_29_215 at #439: I87 I 4614159_29_215 at #440: Q88 4614159_29_215 at #440: Q88 Q 4614159_29_215 at #441: I89 4614159_29_215 at #441: I89 I 4614159_29_215 at #442: L90 4614159_29_215 at #442: L90 L 4614159_29_215 at #443: D91 4614159_29_215 at #443: D91 D 4614159_29_215 at #450: N92 4614159_29_215 at #450: N92 N 4614159_29_215 at #451: T93 4614159_29_215 at #451: T93 T 4614159_29_215 at #452: H94 4614159_29_215 at #452: H94 H 4614159_29_215 at #453: P95 4614159_29_215 at #453: P95 P 4614159_29_215 at #475: L100 4614159_29_215 at #475: L100 L 4614159_29_215 at #476: K101 4614159_29_215 at #476: K101 K 4614159_29_215 at #477: D102 4614159_29_215 at #477: D102 D 4614159_29_215 at #478: H103 4614159_29_215 at #478: H103 H 4614159_29_215 at #479: Q104 4614159_29_215 at #479: Q104 Q 4614159_29_215 at #480: F105 4614159_29_215 at #480: F105 F 4614159_29_215 at #481: H106 4614159_29_215 at #481: H106 H 4614159_29_215 at #482: G107 4614159_29_215 at #482: G107 G 4614159_29_215 at #483: S108 4614159_29_215 at #483: S108 S 4614159_29_215 at #484: A109 4614159_29_215 at #484: A109 A 4614159_29_215 at #485: Y110 4614159_29_215 at #485: Y110 Y 4614159_29_215 at #486 4614159_29_215 at #486 - 4614159_29_215 at #487 4614159_29_215 at #487 - 4614159_29_215 at #530 4614159_29_215 at #530 - 4614159_29_215 at #532: G111 4614159_29_215 at #532: G111 G 4614159_29_215 at #533: I112 4614159_29_215 at #533: I112 I 4614159_29_215 at #534: A113 4614159_29_215 at #534: A113 A 4614159_29_215 at #535: A114 4614159_29_215 at #535: A114 A 4614159_29_215 at #544: A115 4614159_29_215 at #544: A115 A 4614159_29_215 at #545: K116 4614159_29_215 at #545: K116 K 4614159_29_215 at #548: R117 4614159_29_215 at #548: R117 R 4614159_29_215 at #549: G118 4614159_29_215 at #549: G118 G 4614159_29_215 at #550: F119 4614159_29_215 at #550: F119 F 4614159_29_215 at #551: L120 4614159_29_215 at #551: L120 L 4614159_29_215 at #552: K121 4614159_29_215 at #552: K121 K 4614159_29_215 at #553: P122 4614159_29_215 at #553: P122 P 4614159_29_215 at #554: L123 4614159_29_215 at #554: L123 L 4614159_29_215 at #555: G124 4614159_29_215 at #555: G124 G 4614159_29_215 at #556: E125 4614159_29_215 at #556: E125 E 4614159_29_215 at #557: W126 4614159_29_215 at #557: W126 W 4614159_29_215 at #558: N127 4614159_29_215 at #558: N127 N 4614159_29_215 at #559: Y128 4614159_29_215 at #559: Y128 Y 4614159_29_215 at #560: Q129 4614159_29_215 at #560: Q129 Q 4614159_29_215 at #561: E130 4614159_29_215 at #561: E130 E 4614159_29_215 at #562: I131 4614159_29_215 at #562: I131 I 4614159_29_215 at #565: H132 4614159_29_215 at #565: H132 H 4614159_29_215 at #566: L133 4614159_29_215 at #566: L133 L 4614159_29_215 at #568: K134 4614159_29_215 at #568: K134 K 4614159_29_215 at #570: A135 4614159_29_215 at #570: A135 A 4614159_29_215 at #571: S136 4614159_29_215 at #571: S136 S 4614159_29_215 at #572: H137 4614159_29_215 at #572: H137 H 4614159_29_215 at #588: L138 4614159_29_215 at #588: L138 L 4614159_29_215 at #589: Q139 4614159_29_215 at #589: Q139 Q 4614159_29_215 at #592: V140 4614159_29_215 at #592: V140 V 4614159_29_215 at #594: I141 4614159_29_215 at #594: I141 I 4614159_29_215 at #595: L142 4614159_29_215 at #595: L142 L 4614159_29_215 at #596: N143 4614159_29_215 at #596: N143 N 4614159_29_215 at #598: G144 4614159_29_215 at #598: G144 G 4614159_29_215 at #599: E145 4614159_29_215 at #599: E145 E 4614159_29_215 at #600: K146 4614159_29_215 at #600: K146 K 4614159_29_215 at #601: I147 4614159_29_215 at #601: I147 I 4614159_29_215 at #602: L148 4614159_29_215 at #602: L148 L 4614159_29_215 at #603: D149 4614159_29_215 at #603: D149 D 4614159_29_215 at #604: C150 4614159_29_215 at #604: C150 C 4614159_29_215 at #605: D151 4614159_29_215 at #605: D151 D 4614159_29_215 at #606: I152 4614159_29_215 at #606: I152 I 4614159_29_215 at #607: A153 4614159_29_215 at #607: A153 A 4614159_29_215 at #608: S154 4614159_29_215 at #608: S154 S 4614159_29_215 at #609: G155 4614159_29_215 at #609: G155 G 4614159_29_215 at #610: D156 4614159_29_215 at #610: D156 D 4614159_29_215 at #611: A157 4614159_29_215 at #611: A157 A 4614159_29_215 at #612: G158 4614159_29_215 at #612: G158 G 4614159_29_215 at #613: K159 4614159_29_215 at #613: K159 K 4614159_29_215 at #614: Y160 4614159_29_215 at #614: Y160 Y 4614159_29_215 at #615: A161 4614159_29_215 at #615: A161 A 4614159_29_215 at #616: K162 4614159_29_215 at #616: K162 K 4614159_29_215 at #640: R164 4614159_29_215 at #640: R164 R 4614159_29_215 at #641: D165 4614159_29_215 at #641: D165 D 4614159_29_215 at #642: R166 4614159_29_215 at #642: R166 R 4614159_29_215 at #643: T167 4614159_29_215 at #643: T167 T 4614159_29_215 at #644: S168 4614159_29_215 at #644: S168 S 4614159_29_215 at #645: G169 4614159_29_215 at #645: G169 G 4614159_29_215 at #646: H170 4614159_29_215 at #646: H170 H 4614159_29_215 at #647: I171 4614159_29_215 at #647: I171 I 4614159_29_215 at #648: A172 4614159_29_215 at #648: A172 A 4614159_29_215 at #649: I173 4614159_29_215 at #649: I173 I 4614159_29_215 at #650: A174 4614159_29_215 at #650: A174 A 4614159_29_215 at #653: G175 4614159_29_215 at #653: G175 G 4614159_29_215 at #654: H176 4614159_29_215 at #654: H176 H 4614159_29_215 at #655: G177 4614159_29_215 at #655: G177 G 4614159_29_215 at #668: P178 4614159_29_215 at #668: P178 P 4614159_29_215 at #689: G179 4614159_29_215 at #689: G179 G 4614159_29_215 at #690: V180 4614159_29_215 at #690: V180 V 4614159_29_215 at #691: T181 4614159_29_215 at #691: T181 T 4614159_29_215 at #694: F182 4614159_29_215 at #694: F182 F 4614159_29_215 at #695: R183 4614159_29_215 at #695: R183 R 4614159_29_215 at #696: N184 4614159_29_215 at #696: N184 N 4614159_29_215 at #697: I185 4614159_29_215 at #697: I185 I 4614159_29_215 at #698: S186 4614159_29_215 at #698: S186 S 4614159_29_215 at #699: V187 4614159_29_215 at #699: V187 V 4614159_29_215 at #700 4614159_29_215 at #700 - tandem domain, from Gemmata obscuriglobus UQM 2246 4909469_250_435 tandem domain, from Gemmata obscuriglobus UQM 2246 4909469_250_435 at #155: G1 4909469_250_435 at #155: G1 G 4909469_250_435 at #156: F2 4909469_250_435 at #156: F2 F 4909469_250_435 at #157: E3 4909469_250_435 at #157: E3 E 4909469_250_435 at #158: P4 4909469_250_435 at #158: P4 P 4909469_250_435 at #159: L5 4909469_250_435 at #159: L5 L 4909469_250_435 at #160: F6 4909469_250_435 at #160: F6 F 4909469_250_435 at #162: N7 4909469_250_435 at #162: N7 N 4909469_250_435 at #164: G8 4909469_250_435 at #164: G8 G 4909469_250_435 at #165: T9 4909469_250_435 at #165: T9 T 4909469_250_435 at #168: D10 4909469_250_435 at #168: D10 D 4909469_250_435 at #169: F11 4909469_250_435 at #169: F11 F 4909469_250_435 at #171: D12 4909469_250_435 at #171: D12 D 4909469_250_435 at #172: G13 4909469_250_435 at #172: G13 G 4909469_250_435 at #180: W14 4909469_250_435 at #180: W14 W 4909469_250_435 at #181: A15 4909469_250_435 at #181: A15 A 4909469_250_435 at #185: G16 4909469_250_435 at #185: G16 G 4909469_250_435 at #186: A17 4909469_250_435 at #186: A17 A 4909469_250_435 at #187 4909469_250_435 at #187 - 4909469_250_435 at #188 4909469_250_435 at #188 - 4909469_250_435 at #189: L18 4909469_250_435 at #189: L18 L 4909469_250_435 at #190 4909469_250_435 at #190 - 4909469_250_435 at #191 4909469_250_435 at #191 - 4909469_250_435 at #195 4909469_250_435 at #195 - 4909469_250_435 at #196 4909469_250_435 at #196 - 4909469_250_435 at #197: D19 4909469_250_435 at #197: D19 D 4909469_250_435 at #198: N20 4909469_250_435 at #198: N20 N 4909469_250_435 at #235: E22 4909469_250_435 at #235: E22 E 4909469_250_435 at #236: V23 4909469_250_435 at #236: V23 V 4909469_250_435 at #237: A24 4909469_250_435 at #237: A24 A 4909469_250_435 at #238: D25 4909469_250_435 at #238: D25 D 4909469_250_435 at #240: G26 4909469_250_435 at #240: G26 G 4909469_250_435 at #268: A27 4909469_250_435 at #268: A27 A 4909469_250_435 at #269: I28 4909469_250_435 at #269: I28 I 4909469_250_435 at #270: V29 4909469_250_435 at #270: V29 V 4909469_250_435 at #294 4909469_250_435 at #294 - 4909469_250_435 at #295: C30 4909469_250_435 at #295: C30 C 4909469_250_435 at #296: K31 4909469_250_435 at #296: K31 K 4909469_250_435 at #297: K32 4909469_250_435 at #297: K32 K 4909469_250_435 at #298: G33 4909469_250_435 at #298: G33 G 4909469_250_435 at #299: K34 4909469_250_435 at #299: K34 K 4909469_250_435 at #300: G35 4909469_250_435 at #300: G35 G 4909469_250_435 at #301: G36 4909469_250_435 at #301: G36 G 4909469_250_435 at #303: N37 4909469_250_435 at #303: N37 N 4909469_250_435 at #304: V38 4909469_250_435 at #304: V38 V 4909469_250_435 at #305: Y39 4909469_250_435 at #305: Y39 Y 4909469_250_435 at #306: A40 4909469_250_435 at #306: A40 A 4909469_250_435 at #312: K41 4909469_250_435 at #312: K41 K 4909469_250_435 at #318: P42 4909469_250_435 at #318: P42 P 4909469_250_435 at #321: E43 4909469_250_435 at #321: E43 E 4909469_250_435 at #322: F44 4909469_250_435 at #322: F44 F 4909469_250_435 at #324: A45 4909469_250_435 at #324: A45 A 4909469_250_435 at #326: D46 4909469_250_435 at #326: D46 D 4909469_250_435 at #327: F47 4909469_250_435 at #327: F47 F 4909469_250_435 at #328: V48 4909469_250_435 at #328: V48 V 4909469_250_435 at #329: V49 4909469_250_435 at #329: V49 V 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4909469_250_435 at #700: R186 4909469_250_435 at #700: R186 R download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory