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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10307487_204_385: tandem domain, from Pirellula staleyi DSM 6068 (has NEQ) 2760771_804_979: with other domain, from Blastopirellula marina DSM 3645 (has DQQ) 2762174_615_790: with other domain, from Blastopirellula marina DSM 3645 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 10307487_204_385 has N64 EQ 2760771_804_979 has D64 QQ 2762174_615_790 has N64 EQ 10307487_204_385 has N64 aligning to 134N 2760771_804_979 has D64 aligning to 134D 2762174_615_790 has N64 aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 10307487_204_385 has N E85 Q 2760771_804_979 has D Q84 Q 2762174_615_790 has N E84 Q 10307487_204_385 has E85 aligning to 164E 2760771_804_979 has Q84 aligning to 164Q 2762174_615_790 has E84 aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 10307487_204_385 has NE Q87 2760771_804_979 has DQ Q86 2762174_615_790 has NE Q86 10307487_204_385 and 2 similar proteins have Q aligning to 166Q 10307487_204_385: tandem domain, from Pirellula staleyi DSM 6068 10307487_204_38510307487_204_385: tandem domain, from Pirellula staleyi DSM 6068 0.999 2760771_804_979: with other domain, from Blastopirellula marina DSM 3645 2760771_804_9792760771_804_979: with other domain, from Blastopirellula marina DSM 3645 2762174_615_790: with other domain, from Blastopirellula marina DSM 3645 2762174_615_7902762174_615_790: with other domain, from Blastopirellula marina DSM 3645 10307487_204_385: tandem domain, from Pirellula staleyi DSM 6068 (has NEQ)10307487_204_385 tandem domain, from Pirellula staleyi DSM 6068 2760771_804_979: with other domain, from Blastopirellula marina DSM 3645 (has DQQ)2760771_804_979 with other domain, from Blastopirellula marina DSM 3645 2762174_615_790: with other domain, from Blastopirellula marina DSM 3645 (has NEQ)2762174_615_790 with other domain, from Blastopirellula marina DSM 3645 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory