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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

7376920_669_882: with redox domain, from Methylobacterium nodulans ORS 2060 (has NEQ) 5653674_1059_1234: with redox domain, from Streptomyces griseus subsp. griseus NBRC 13350 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 7376920_669_882 has N62 EQ 5653674_1059_1234 has N60 EQ 7376920_669_882 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 7376920_669_882 has N E98 Q 5653674_1059_1234 has N E82 Q 7376920_669_882 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 7376920_669_882 has NE Q100 5653674_1059_1234 has NE Q84 7376920_669_882 and 1 similar proteins have Q aligning to 166Q 7376920_669_882: with redox domain, from Methylobacterium nodulans ORS 2060 7376920_669_8827376920_669_882: with redox domain, from Methylobacterium nodulans ORS 2060 5653674_1059_1234: with redox domain, from Streptomyces griseus subsp. griseus NBRC 13350 5653674_1059_12345653674_1059_1234: with redox domain, from Streptomyces griseus subsp. griseus NBRC 13350 7376920_669_882: with redox domain, from Methylobacterium nodulans ORS 2060 (has NEQ)7376920_669_882 with redox domain, from Methylobacterium nodulans ORS 2060 5653674_1059_1234: with redox domain, from Streptomyces griseus subsp. griseus NBRC 13350 (has NEQ)5653674_1059_1234 with redox domain, from Streptomyces griseus subsp. griseus NBRC 13350 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory