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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

3772626_642_829: with redox domain, from Microcystis aeruginosa NIES-843 (has NEQ) 4904579_682_860: with redox domain, from Gemmata obscuriglobus UQM 2246 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 3772626_642_829 has N64 EQ 4904579_682_860 has N32 EQ 3772626_642_829 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 3772626_642_829 has N E85 Q 4904579_682_860 has N E56 Q 3772626_642_829 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 3772626_642_829 has NE Q87 4904579_682_860 has NE Q58 3772626_642_829 and 1 similar proteins have Q aligning to 166Q 3772626_642_829: with redox domain, from Microcystis aeruginosa NIES-843 3772626_642_8293772626_642_829: with redox domain, from Microcystis aeruginosa NIES-843 4904579_682_860: with redox domain, from Gemmata obscuriglobus UQM 2246 4904579_682_8604904579_682_860: with redox domain, from Gemmata obscuriglobus UQM 2246 3772626_642_829: with redox domain, from Microcystis aeruginosa NIES-843 (has NEQ)3772626_642_829 with redox domain, from Microcystis aeruginosa NIES-843 4904579_682_860: with redox domain, from Gemmata obscuriglobus UQM 2246 (has NEQ)4904579_682_860 with redox domain, from Gemmata obscuriglobus UQM 2246 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory