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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

1.000 2225943_20_213: single domain, from Solibacter usitatus Ellin6076 11176218_20_201: single domain, from Gillisia limnaea R-8282, DSM 15749 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Solibacter usitatus Ellin6076 2225943_20_213 single domain, from Solibacter usitatus Ellin6076 2225943_20_213 at #155 2225943_20_213 at #155 - 2225943_20_213 at #156 2225943_20_213 at #156 - 2225943_20_213 at #157: I1 2225943_20_213 at #157: I1 I 2225943_20_213 at #158: K2 2225943_20_213 at #158: K2 K 2225943_20_213 at #159: L3 2225943_20_213 at #159: L3 L 2225943_20_213 at #160: W4 2225943_20_213 at #160: W4 W 2225943_20_213 at #162: N5 2225943_20_213 at #162: N5 N 2225943_20_213 at #164: G6 2225943_20_213 at #164: G6 G 2225943_20_213 at #165: K7 2225943_20_213 at #165: K7 K 2225943_20_213 at #168: N8 2225943_20_213 at #168: N8 N 2225943_20_213 at #169: L9 2225943_20_213 at #169: L9 L 2225943_20_213 at #171: D10 2225943_20_213 at #171: D10 D 2225943_20_213 at #172: G11 2225943_20_213 at #172: G11 G 2225943_20_213 at #180: W12 2225943_20_213 at #180: W12 W 2225943_20_213 at #181: S13 2225943_20_213 at #181: S13 S 2225943_20_213 at #185: R14 2225943_20_213 at #185: R14 R 2225943_20_213 at #186: L15 2225943_20_213 at #186: L15 L 2225943_20_213 at #187: T16 2225943_20_213 at #187: T16 T 2225943_20_213 at #188: R17 2225943_20_213 at #188: R17 R 2225943_20_213 at #189: H18 2225943_20_213 at #189: H18 H 2225943_20_213 at #190: E19 2225943_20_213 at #190: E19 E 2225943_20_213 at #191: G20 2225943_20_213 at #191: G20 G 2225943_20_213 at #195: E21 2225943_20_213 at #195: E21 E 2225943_20_213 at #196: A22 2225943_20_213 at #196: A22 A 2225943_20_213 at #197: D23 2225943_20_213 at #197: D23 D 2225943_20_213 at #198: H24 2225943_20_213 at #198: H24 H 2225943_20_213 at #235: K29 2225943_20_213 at #235: K29 K 2225943_20_213 at #236: I30 2225943_20_213 at #236: I30 I 2225943_20_213 at #237: A31 2225943_20_213 at #237: A31 A 2225943_20_213 at #238: N32 2225943_20_213 at #238: N32 N 2225943_20_213 at #240: G33 2225943_20_213 at #240: G33 G 2225943_20_213 at #268: L34 2225943_20_213 at #268: L34 L 2225943_20_213 at #269: L35 2225943_20_213 at #269: L35 L 2225943_20_213 at #270: I36 2225943_20_213 at #270: I36 I 2225943_20_213 at #294: T37 2225943_20_213 at #294: T37 T 2225943_20_213 at #295: D38 2225943_20_213 at #295: D38 D 2225943_20_213 at #296: P39 2225943_20_213 at #296: P39 P 2225943_20_213 at #297: N40 2225943_20_213 at #297: N40 N 2225943_20_213 at #298: A41 2225943_20_213 at #298: A41 A 2225943_20_213 at #299: P42 2225943_20_213 at #299: P42 P 2225943_20_213 at #300: E43 2225943_20_213 at #300: E43 E 2225943_20_213 at #301: D44 2225943_20_213 at #301: D44 D 2225943_20_213 at #303: D45 2225943_20_213 at #303: D45 D 2225943_20_213 at #304: I46 2225943_20_213 at #304: I46 I 2225943_20_213 at #305: W47 2225943_20_213 at #305: W47 W 2225943_20_213 at #306: Y48 2225943_20_213 at #306: Y48 Y 2225943_20_213 at #312: P49 2225943_20_213 at #312: P49 P 2225943_20_213 at #318: K50 2225943_20_213 at #318: K50 K 2225943_20_213 at #321: K52 2225943_20_213 at #321: K52 K 2225943_20_213 at #322: I53 2225943_20_213 at #322: I53 I 2225943_20_213 at #324: G54 2225943_20_213 at #324: G54 G 2225943_20_213 at #326: N55 2225943_20_213 at #326: N55 N 2225943_20_213 at #327: A56 2225943_20_213 at #327: A56 A 2225943_20_213 at #328: T57 2225943_20_213 at #328: T57 T 2225943_20_213 at #329: I58 2225943_20_213 at #329: I58 I 2225943_20_213 at #330: R59 2225943_20_213 at #330: R59 R 2225943_20_213 at #331: V60 2225943_20_213 at #331: V60 V 2225943_20_213 at #332: V61 2225943_20_213 at #332: V61 V 2225943_20_213 at #333: Y62 2225943_20_213 at #333: Y62 Y 2225943_20_213 at #334: K63 2225943_20_213 at #334: K63 K 2225943_20_213 at #335: V64 2225943_20_213 at #335: V64 V 2225943_20_213 at #351: S66 2225943_20_213 at #351: S66 S 2225943_20_213 at #352: E67 2225943_20_213 at #352: E67 E 2225943_20_213 at #354: R68 2225943_20_213 at #354: R68 R 2225943_20_213 at #355: A69 2225943_20_213 at #355: A69 A 2225943_20_213 at #385: N70 2225943_20_213 at #385: N70 N 2225943_20_213 at #386: S71 2225943_20_213 at #386: S71 S 2225943_20_213 at #387: G72 2225943_20_213 at #387: G72 G 2225943_20_213 at #388: I73 2225943_20_213 at #388: I73 I 2225943_20_213 at #389: F74 2225943_20_213 at #389: F74 F 2225943_20_213 at #390: I75 2225943_20_213 at #390: I75 I 2225943_20_213 at #391: R76 2225943_20_213 at #391: R76 R 2225943_20_213 at #392: I77 2225943_20_213 at #392: I77 I 2225943_20_213 at #393: P78 2225943_20_213 at #393: P78 P 2225943_20_213 at #423: K82 2225943_20_213 at #423: K82 K 2225943_20_213 at #424: S83 2225943_20_213 at #424: S83 S 2225943_20_213 at #425: E84 2225943_20_213 at #425: E84 E 2225943_20_213 at #426: D85 2225943_20_213 at #426: D85 D 2225943_20_213 at #430: D86 2225943_20_213 at #430: D86 D 2225943_20_213 at #431: A87 2225943_20_213 at #431: A87 A 2225943_20_213 at #432: I88 2225943_20_213 at #432: I88 I 2225943_20_213 at #433: N89 2225943_20_213 at #433: N89 N 2225943_20_213 at #434: K90 2225943_20_213 at #434: K90 K 2225943_20_213 at #435: G91 2225943_20_213 at #435: G91 G 2225943_20_213 at #436: I92 2225943_20_213 at #436: I92 I 2225943_20_213 at #438: E93 2225943_20_213 at #438: E93 E 2225943_20_213 at #439: V94 2225943_20_213 at #439: V94 V 2225943_20_213 at #440: Q95 2225943_20_213 at #440: Q95 Q 2225943_20_213 at #441: I96 2225943_20_213 at #441: I96 I 2225943_20_213 at #442: D97 2225943_20_213 at #442: D97 D 2225943_20_213 at #443: Q98 2225943_20_213 at #443: Q98 Q 2225943_20_213 at #450: G99 2225943_20_213 at #450: G99 G 2225943_20_213 at #451: D100 2225943_20_213 at #451: D100 D 2225943_20_213 at #452: D101 2225943_20_213 at #452: D101 D 2225943_20_213 at #453: D102 2225943_20_213 at #453: D102 D 2225943_20_213 at #475 2225943_20_213 at #475 - 2225943_20_213 at #476 2225943_20_213 at #476 - 2225943_20_213 at #477 2225943_20_213 at #477 - 2225943_20_213 at #478: W103 2225943_20_213 at #478: W103 W 2225943_20_213 at #479: H104 2225943_20_213 at #479: H104 H 2225943_20_213 at #480: C105 2225943_20_213 at #480: C105 C 2225943_20_213 at #481: T106 2225943_20_213 at #481: T106 T 2225943_20_213 at #482: G107 2225943_20_213 at #482: G107 G 2225943_20_213 at #483: V108 2225943_20_213 at #483: V108 V 2225943_20_213 at #484: L109 2225943_20_213 at #484: L109 L 2225943_20_213 at #485: Y110 2225943_20_213 at #485: Y110 Y 2225943_20_213 at #486 2225943_20_213 at #486 - 2225943_20_213 at #487 2225943_20_213 at #487 - 2225943_20_213 at #530 2225943_20_213 at #530 - 2225943_20_213 at #532: S111 2225943_20_213 at #532: S111 S 2225943_20_213 at #533: M112 2225943_20_213 at #533: M112 M 2225943_20_213 at #534: V113 2225943_20_213 at #534: V113 V 2225943_20_213 at #535: K114 2225943_20_213 at #535: K114 K 2225943_20_213 at #544: A115 2225943_20_213 at #544: A115 A 2225943_20_213 at #545: K116 2225943_20_213 at #545: K116 K 2225943_20_213 at #548: A117 2225943_20_213 at #548: A117 A 2225943_20_213 at #549: R118 2225943_20_213 at #549: R118 R 2225943_20_213 at #550: P119 2225943_20_213 at #550: P119 P 2225943_20_213 at #551: S120 2225943_20_213 at #551: S120 S 2225943_20_213 at #552: K121 2225943_20_213 at #552: K121 K 2225943_20_213 at #553: P122 2225943_20_213 at #553: P122 P 2225943_20_213 at #554: I123 2225943_20_213 at #554: I123 I 2225943_20_213 at #555: G124 2225943_20_213 at #555: G124 G 2225943_20_213 at #556: E125 2225943_20_213 at #556: E125 E 2225943_20_213 at #557: W126 2225943_20_213 at #557: W126 W 2225943_20_213 at #558: N127 2225943_20_213 at #558: N127 N 2225943_20_213 at #559: T128 2225943_20_213 at #559: T128 T 2225943_20_213 at #560: M129 2225943_20_213 at #560: M129 M 2225943_20_213 at #561: E130 2225943_20_213 at #561: E130 E 2225943_20_213 at #562: I131 2225943_20_213 at #562: I131 I 2225943_20_213 at #565: K132 2225943_20_213 at #565: K132 K 2225943_20_213 at #566: M133 2225943_20_213 at #566: M133 M 2225943_20_213 at #568: Q134 2225943_20_213 at #568: Q134 Q 2225943_20_213 at #570: G135 2225943_20_213 at #570: G135 G 2225943_20_213 at #571: P136 2225943_20_213 at #571: P136 P 2225943_20_213 at #572: R137 2225943_20_213 at #572: R137 R 2225943_20_213 at #588: T138 2225943_20_213 at #588: T138 T 2225943_20_213 at #589: I139 2225943_20_213 at #589: I139 I 2225943_20_213 at #592: V140 2225943_20_213 at #592: V140 V 2225943_20_213 at #594: T141 2225943_20_213 at #594: T141 T 2225943_20_213 at #595: V142 2225943_20_213 at #595: V142 V 2225943_20_213 at #596: N143 2225943_20_213 at #596: N143 N 2225943_20_213 at #598: G144 2225943_20_213 at #598: G144 G 2225943_20_213 at #599: V145 2225943_20_213 at #599: V145 V 2225943_20_213 at #600: L146 2225943_20_213 at #600: L146 L 2225943_20_213 at #601: V147 2225943_20_213 at #601: V147 V 2225943_20_213 at #602: T148 2225943_20_213 at #602: T148 T 2225943_20_213 at #603: D149 2225943_20_213 at #603: D149 D 2225943_20_213 at #604: Y150 2225943_20_213 at #604: Y150 Y 2225943_20_213 at #605: D151 2225943_20_213 at #605: D151 D 2225943_20_213 at #606: G152 2225943_20_213 at #606: G152 G 2225943_20_213 at #607: V153 2225943_20_213 at #607: V153 V 2225943_20_213 at #608: T154 2225943_20_213 at #608: T154 T 2225943_20_213 at #609: P155 2225943_20_213 at #609: P155 P 2225943_20_213 at #610: A156 2225943_20_213 at #610: A156 A 2225943_20_213 at #611: P157 2225943_20_213 at #611: P157 P 2225943_20_213 at #612: E158 2225943_20_213 at #612: E158 E 2225943_20_213 at #613: K159 2225943_20_213 at #613: K159 K 2225943_20_213 at #614: V160 2225943_20_213 at #614: V160 V 2225943_20_213 at #615: K161 2225943_20_213 at #615: K161 K 2225943_20_213 at #616: S162 2225943_20_213 at #616: S162 S 2225943_20_213 at #640: R169 2225943_20_213 at #640: R169 R 2225943_20_213 at #641: R170 2225943_20_213 at #641: R170 R 2225943_20_213 at #642: P171 2225943_20_213 at #642: P171 P 2225943_20_213 at #643: D172 2225943_20_213 at #643: D172 D 2225943_20_213 at #644: T173 2225943_20_213 at #644: T173 T 2225943_20_213 at #645: G174 2225943_20_213 at #645: G174 G 2225943_20_213 at #646: F175 2225943_20_213 at #646: F175 F 2225943_20_213 at #647: I176 2225943_20_213 at #647: I176 I 2225943_20_213 at #648: A177 2225943_20_213 at #648: A177 A 2225943_20_213 at #649: V178 2225943_20_213 at #649: V178 V 2225943_20_213 at #650: Q179 2225943_20_213 at #650: Q179 Q 2225943_20_213 at #653: H180 2225943_20_213 at #653: H180 H 2225943_20_213 at #654: H181 2225943_20_213 at #654: H181 H 2225943_20_213 at #655: S182 2225943_20_213 at #655: S182 S 2225943_20_213 at #668: G185 2225943_20_213 at #668: G185 G 2225943_20_213 at #689: V186 2225943_20_213 at #689: V186 V 2225943_20_213 at #690: V187 2225943_20_213 at #690: V187 V 2225943_20_213 at #691: T188 2225943_20_213 at #691: T188 T 2225943_20_213 at #694: F189 2225943_20_213 at #694: F189 F 2225943_20_213 at #695: K190 2225943_20_213 at #695: K190 K 2225943_20_213 at #696: E191 2225943_20_213 at #696: E191 E 2225943_20_213 at #697: I192 2225943_20_213 at #697: I192 I 2225943_20_213 at #698: T193 2225943_20_213 at #698: T193 T 2225943_20_213 at #699 2225943_20_213 at #699 - 2225943_20_213 at #700 2225943_20_213 at #700 - single domain, from Gillisia limnaea R-8282, DSM 15749 11176218_20_201 single domain, from Gillisia limnaea R-8282, DSM 15749 11176218_20_201 at #155: E1 11176218_20_201 at #155: E1 E 11176218_20_201 at #156: W2 11176218_20_201 at #156: W2 W 11176218_20_201 at #157: I3 11176218_20_201 at #157: I3 I 11176218_20_201 at #158: P4 11176218_20_201 at #158: P4 P 11176218_20_201 at #159: L5 11176218_20_201 at #159: L5 L 11176218_20_201 at #160: F6 11176218_20_201 at #160: F6 F 11176218_20_201 at #162: N7 11176218_20_201 at #162: N7 N 11176218_20_201 at #164: G8 11176218_20_201 at #164: G8 G 11176218_20_201 at #165: E9 11176218_20_201 at #165: E9 E 11176218_20_201 at #168: N10 11176218_20_201 at #168: N10 N 11176218_20_201 at #169: M11 11176218_20_201 at #169: M11 M 11176218_20_201 at #171: E12 11176218_20_201 at #171: E12 E 11176218_20_201 at #172: G13 11176218_20_201 at #172: G13 G 11176218_20_201 at #180: W14 11176218_20_201 at #180: W14 W 11176218_20_201 at #181: E15 11176218_20_201 at #181: E15 E 11176218_20_201 at #185: Q16 11176218_20_201 at #185: Q16 Q 11176218_20_201 at #186: V17 11176218_20_201 at #186: V17 V 11176218_20_201 at #187: G18 11176218_20_201 at #187: G18 G 11176218_20_201 at #188: N19 11176218_20_201 at #188: N19 N 11176218_20_201 at #189: G20 11176218_20_201 at #189: G20 G 11176218_20_201 at #190: N21 11176218_20_201 at #190: N21 N 11176218_20_201 at #191: F22 11176218_20_201 at #191: F22 F 11176218_20_201 at #195: I23 11176218_20_201 at #195: I23 I 11176218_20_201 at #196 11176218_20_201 at #196 - 11176218_20_201 at #197 11176218_20_201 at #197 - 11176218_20_201 at #198 11176218_20_201 at #198 - 11176218_20_201 at #235 11176218_20_201 at #235 - 11176218_20_201 at #236: L24 11176218_20_201 at #236: L24 L 11176218_20_201 at #237: E25 11176218_20_201 at #237: E25 E 11176218_20_201 at #238: N26 11176218_20_201 at #238: N26 N 11176218_20_201 at #240: G27 11176218_20_201 at #240: G27 G 11176218_20_201 at #268: M28 11176218_20_201 at #268: M28 M 11176218_20_201 at #269: L29 11176218_20_201 at #269: L29 L 11176218_20_201 at #270: K30 11176218_20_201 at #270: K30 K 11176218_20_201 at #294 11176218_20_201 at #294 - 11176218_20_201 at #295 11176218_20_201 at #295 - 11176218_20_201 at #296: S31 11176218_20_201 at #296: S31 S 11176218_20_201 at #297: S32 11176218_20_201 at #297: S32 S 11176218_20_201 at #298: G33 11176218_20_201 at #298: G33 G 11176218_20_201 at #299: G34 11176218_20_201 at #299: G34 G 11176218_20_201 at #300: M35 11176218_20_201 at #300: M35 M 11176218_20_201 at #301: G36 11176218_20_201 at #301: G36 G 11176218_20_201 at #303: L37 11176218_20_201 at #303: L37 L 11176218_20_201 at #304: L38 11176218_20_201 at #304: L38 L 11176218_20_201 at #305: W39 11176218_20_201 at #305: W39 W 11176218_20_201 at #306: F40 11176218_20_201 at #306: F40 F 11176218_20_201 at #312: T41 11176218_20_201 at #312: T41 T 11176218_20_201 at #318: K43 11176218_20_201 at #318: K43 K 11176218_20_201 at #321: K44 11176218_20_201 at #321: K44 K 11176218_20_201 at #322: F45 11176218_20_201 at #322: F45 F 11176218_20_201 at #324: E46 11176218_20_201 at #324: E46 E 11176218_20_201 at #326: N47 11176218_20_201 at #326: N47 N 11176218_20_201 at #327: A48 11176218_20_201 at #327: A48 A 11176218_20_201 at #328: R49 11176218_20_201 at #328: R49 R 11176218_20_201 at #329: I50 11176218_20_201 at #329: I50 I 11176218_20_201 at #330: K51 11176218_20_201 at #330: K51 K 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory