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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4594548_352_539: with other domain, near sugar dehydrogenase, from Planctomyces maris DSM 8797 (has NEQ) 4614230_39_205: single domain, from Lentisphaera araneosa HTCC2155 (has NEQ) 6253107_21_166: single domain, from Chthoniobacter flavus Ellin428 (has NEQ) 11294916_26_207: single domain, from Planctomyces brasiliensis DSM 5305 (has NEQ) 2224519_22_203: single domain, from Solibacter usitatus Ellin6076 (has NQQ) BT2157 has N at position 134 (alignment position 385)N134 4594548_352_539 has N63 EQ 4614230_39_205 has N42 EQ 6253107_21_166 has N16 EQ 11294916_26_207 has N69 EQ 2224519_22_203 has N76 QQ 4594548_352_539 and 4 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 4594548_352_539 has N E82 Q 4614230_39_205 has N E60 Q 6253107_21_166 has N E34 Q 11294916_26_207 has N E88 Q 2224519_22_203 has N Q92 Q 4594548_352_539 and 2 similar proteins have E aligning to 164E 11294916_26_207 has E88 aligning to 164E 2224519_22_203 has Q92 aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 4594548_352_539 has NE Q84 4614230_39_205 has NE Q62 6253107_21_166 has NE Q36 11294916_26_207 has NE Q90 2224519_22_203 has NQ Q94 4594548_352_539 and 4 similar proteins have Q aligning to 166Q 0.973 4594548_352_539: with other domain, near sugar dehydrogenase, from Planctomyces maris DSM 8797 4594548_352_5394594548_352_539: with other domain, near sugar dehydrogenase, from Planctomyces maris DSM 8797 0.793 4614230_39_205: single domain, from Lentisphaera araneosa HTCC2155 4614230_39_2054614230_39_205: single domain, from Lentisphaera araneosa HTCC2155 6253107_21_166: single domain, from Chthoniobacter flavus Ellin428 6253107_21_1666253107_21_166: single domain, from Chthoniobacter flavus Ellin428 0.899 11294916_26_207: single domain, from Planctomyces brasiliensis DSM 5305 11294916_26_20711294916_26_207: single domain, from Planctomyces brasiliensis DSM 5305 2224519_22_203: single domain, from Solibacter usitatus Ellin6076 2224519_22_2032224519_22_203: single domain, from Solibacter usitatus Ellin6076 4594548_352_539: with other domain, near sugar dehydrogenase, from Planctomyces maris DSM 8797 (has NEQ)4594548_352_539 with other domain, near sugar dehydrogenase, from Planctomyces maris DSM 8797 4614230_39_205: single domain, from Lentisphaera araneosa HTCC2155 (has NEQ)4614230_39_205 single domain, from Lentisphaera araneosa HTCC2155 6253107_21_166: single domain, from Chthoniobacter flavus Ellin428 (has NEQ)6253107_21_166 single domain, from Chthoniobacter flavus Ellin428 11294916_26_207: single domain, from Planctomyces brasiliensis DSM 5305 (has NEQ)11294916_26_207 single domain, from Planctomyces brasiliensis DSM 5305 2224519_22_203: single domain, from Solibacter usitatus Ellin6076 (has NQQ)2224519_22_203 single domain, from Solibacter usitatus Ellin6076 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory