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Zoomed into a clade of 8 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6254985_35_202: single domain, from Chthoniobacter flavus Ellin428 (has DQQ) 7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 (has DQQ) 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 (has DQQ) 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has DQQ) 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 (has DQQ) 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 (has DQQ) 4594702_67_283: single domain, from Planctomyces maris DSM 8797 (has DQN) 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 (has EEE) BT2157 has N at position 134 (alignment position 385)N134 6254985_35_202 has D62 QQ 7462545_728_927 has D89 QQ 2223539_22_227 has D90 QQ 4614159_234_440 has D92 QQ 4908012_29_247 has D85 QQ 11292817_33_232 has D83 QQ 4594702_67_283 has D97 QN 6251338_238_441 has E75 EE 6254985_35_202 and 5 similar proteins have D aligning to 134D 4594702_67_283 has D97 aligning to 134D 6251338_238_441 has E75 aligning to 134E BT2157 has E at position 164 (alignment position 438)E164 6254985_35_202 has D Q72 Q 7462545_728_927 has D Q99 Q 2223539_22_227 has D Q100 Q 4614159_234_440 has D Q102 Q 4908012_29_247 has D Q95 Q 11292817_33_232 has D Q93 Q 4594702_67_283 has D Q109 N 6251338_238_441 has E E89 E 6254985_35_202 and 5 similar proteins have Q aligning to 164Q 4594702_67_283 has Q109 aligning to 164Q 6251338_238_441 has E89 aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 6254985_35_202 has DQ Q74 7462545_728_927 has DQ Q101 2223539_22_227 has DQ Q102 4614159_234_440 has DQ Q104 4908012_29_247 has DQ Q97 11292817_33_232 has DQ Q95 4594702_67_283 has DQ N111 6251338_238_441 has EE E91 6254985_35_202 and 5 similar proteins have Q aligning to 166Q 4594702_67_283 has N111 aligning to 166N 6251338_238_441 has E91 aligning to 166E 0.849 6254985_35_202: single domain, from Chthoniobacter flavus Ellin428 6254985_35_2026254985_35_202: single domain, from Chthoniobacter flavus Ellin428 0.909 0.744 7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 7462545_728_9277462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 0.758 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 2223539_22_2272223539_22_227: single domain, from Solibacter usitatus Ellin6076 0.806 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_234_4404614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 4908012_29_2474908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 11292817_33_23211292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 0.056 4594702_67_283: single domain, from Planctomyces maris DSM 8797 4594702_67_2834594702_67_283: single domain, from Planctomyces maris DSM 8797 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 6251338_238_4416251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 6254985_35_202: single domain, from Chthoniobacter flavus Ellin428 (has DQQ)6254985_35_202 single domain, from Chthoniobacter flavus Ellin428 7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 (has DQQ)7462545_728_927 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 (has DQQ)2223539_22_227 single domain, from Solibacter usitatus Ellin6076 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has DQQ)4614159_234_440 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 (has DQQ)4908012_29_247 single domain, from Gemmata obscuriglobus UQM 2246 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 (has DQQ)11292817_33_232 single domain, from Planctomyces brasiliensis DSM 5305 4594702_67_283: single domain, from Planctomyces maris DSM 8797 (has DQN)4594702_67_283 single domain, from Planctomyces maris DSM 8797 6251338_238_441: tandem domain, from Chthoniobacter flavus Ellin428 (has EEE)6251338_238_441 tandem domain, from Chthoniobacter flavus Ellin428 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory