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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.998 558057_260_435: tandem domain, from Pirellula sp. 1 10307912_359_538: tandem domain, from Pirellula staleyi DSM 6068 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 tandem domain, from Pirellula sp. 1 558057_260_435 tandem domain, from Pirellula sp. 1 558057_260_435 at #155 558057_260_435 at #155 - 558057_260_435 at #156 558057_260_435 at #156 - 558057_260_435 at #157 558057_260_435 at #157 - 558057_260_435 at #158 558057_260_435 at #158 - 558057_260_435 at #159 558057_260_435 at #159 - 558057_260_435 at #160 558057_260_435 at #160 - 558057_260_435 at #162 558057_260_435 at #162 - 558057_260_435 at #164 558057_260_435 at #164 - 558057_260_435 at #165 558057_260_435 at #165 - 558057_260_435 at #168 558057_260_435 at #168 - 558057_260_435 at #169: L4 558057_260_435 at #169: L4 L 558057_260_435 at #171: E5 558057_260_435 at #171: E5 E 558057_260_435 at #172: G6 558057_260_435 at #172: G6 G 558057_260_435 at #180: W7 558057_260_435 at #180: W7 W 558057_260_435 at #181: T8 558057_260_435 at #181: T8 T 558057_260_435 at #185: V9 558057_260_435 at #185: V9 V 558057_260_435 at #186: R10 558057_260_435 at #186: R10 R 558057_260_435 at #187: E11 558057_260_435 at #187: E11 E 558057_260_435 at #188: G12 558057_260_435 at #188: G12 G 558057_260_435 at #189: M13 558057_260_435 at #189: M13 M 558057_260_435 at #190: E14 558057_260_435 at #190: E14 E 558057_260_435 at #191: G15 558057_260_435 at #191: G15 G 558057_260_435 at #195: E16 558057_260_435 at #195: E16 E 558057_260_435 at #196 558057_260_435 at #196 - 558057_260_435 at #197 558057_260_435 at #197 - 558057_260_435 at #198: Y17 558057_260_435 at #198: Y17 Y 558057_260_435 at #235: I19 558057_260_435 at #235: I19 I 558057_260_435 at #236: D20 558057_260_435 at #236: D20 D 558057_260_435 at #237: D21 558057_260_435 at #237: D21 D 558057_260_435 at #238: D22 558057_260_435 at #238: D22 D 558057_260_435 at #240: G23 558057_260_435 at #240: G23 G 558057_260_435 at #268: H24 558057_260_435 at #268: H24 H 558057_260_435 at #269: L25 558057_260_435 at #269: L25 L 558057_260_435 at #270: V26 558057_260_435 at #270: V26 V 558057_260_435 at #294 558057_260_435 at #294 - 558057_260_435 at #295 558057_260_435 at #295 - 558057_260_435 at #296: V27 558057_260_435 at #296: V27 V 558057_260_435 at #297: D28 558057_260_435 at #297: D28 D 558057_260_435 at #298: G29 558057_260_435 at #298: G29 G 558057_260_435 at #299: G30 558057_260_435 at #299: G30 G 558057_260_435 at #300: K31 558057_260_435 at #300: K31 K 558057_260_435 at #301: Q32 558057_260_435 at #301: Q32 Q 558057_260_435 at #303: Q33 558057_260_435 at #303: Q33 Q 558057_260_435 at #304: L34 558057_260_435 at #304: L34 L 558057_260_435 at #305: E35 558057_260_435 at #305: E35 E 558057_260_435 at #306: T36 558057_260_435 at #306: T36 T 558057_260_435 at #312: K37 558057_260_435 at #312: K37 K 558057_260_435 at #318: A38 558057_260_435 at #318: A38 A 558057_260_435 at #321: V39 558057_260_435 at #321: V39 V 558057_260_435 at #322: F40 558057_260_435 at #322: F40 F 558057_260_435 at #324: G41 558057_260_435 at #324: G41 G 558057_260_435 at #326: D42 558057_260_435 at #326: D42 D 558057_260_435 at #327: F43 558057_260_435 at #327: F43 F 558057_260_435 at #328: V44 558057_260_435 at #328: V44 V 558057_260_435 at #329: M45 558057_260_435 at #329: M45 M 558057_260_435 at #330: L46 558057_260_435 at #330: L46 L 558057_260_435 at #331: A47 558057_260_435 at #331: A47 A 558057_260_435 at #332: D48 558057_260_435 at #332: D48 D 558057_260_435 at #333: Y49 558057_260_435 at #333: Y49 Y 558057_260_435 at #334: K50 558057_260_435 at #334: K50 K 558057_260_435 at #335: M51 558057_260_435 at #335: M51 M 558057_260_435 at #351: D53 558057_260_435 at #351: D53 D 558057_260_435 at #352: P54 558057_260_435 at #352: P54 P 558057_260_435 at #354: K55 558057_260_435 at #354: K55 K 558057_260_435 at #355: S56 558057_260_435 at #355: S56 S 558057_260_435 at #385: N57 558057_260_435 at #385: N57 N 558057_260_435 at #386: S58 558057_260_435 at #386: S58 S 558057_260_435 at #387: G59 558057_260_435 at #387: G59 G 558057_260_435 at #388: L60 558057_260_435 at #388: L60 L 558057_260_435 at #389: F61 558057_260_435 at #389: F61 F 558057_260_435 at #390: F62 558057_260_435 at #390: F62 F 558057_260_435 at #391: R63 558057_260_435 at #391: R63 R 558057_260_435 at #392: A64 558057_260_435 at #392: A64 A 558057_260_435 at #393: I65 558057_260_435 at #393: I65 I 558057_260_435 at #423 558057_260_435 at #423 - 558057_260_435 at #424 558057_260_435 at #424 - 558057_260_435 at #425 558057_260_435 at #425 - 558057_260_435 at #426: P66 558057_260_435 at #426: P66 P 558057_260_435 at #430: G67 558057_260_435 at #430: G67 G 558057_260_435 at #431: D68 558057_260_435 at #431: D68 D 558057_260_435 at #432: E69 558057_260_435 at #432: E69 E 558057_260_435 at #433: M70 558057_260_435 at #433: M70 M 558057_260_435 at #434: M71 558057_260_435 at #434: M71 M 558057_260_435 at #435: G72 558057_260_435 at #435: G72 G 558057_260_435 at #436: Y73 558057_260_435 at #436: Y73 Y 558057_260_435 at #438: E74 558057_260_435 at #438: E74 E 558057_260_435 at #439: C75 558057_260_435 at #439: C75 C 558057_260_435 at #440: Q76 558057_260_435 at #440: Q76 Q 558057_260_435 at #441: V77 558057_260_435 at #441: V77 V 558057_260_435 at #442: S78 558057_260_435 at #442: S78 S 558057_260_435 at #443: N79 558057_260_435 at #443: N79 N 558057_260_435 at #450: E80 558057_260_435 at #450: E80 E 558057_260_435 at #451: L81 558057_260_435 at #451: L81 L 558057_260_435 at #452: I82 558057_260_435 at #452: I82 I 558057_260_435 at #453: D83 558057_260_435 at #453: D83 D 558057_260_435 at #475: Q88 558057_260_435 at #475: Q88 Q 558057_260_435 at #476: P89 558057_260_435 at #476: P89 P 558057_260_435 at #477: A90 558057_260_435 at #477: A90 A 558057_260_435 at #478: D91 558057_260_435 at #478: D91 D 558057_260_435 at #479: C92 558057_260_435 at #479: C92 C 558057_260_435 at #480: G93 558057_260_435 at #480: G93 G 558057_260_435 at #481: A94 558057_260_435 at #481: A94 A 558057_260_435 at #482: G95 558057_260_435 at #482: G95 G 558057_260_435 at #483: G96 558057_260_435 at #483: G96 G 558057_260_435 at #484: I97 558057_260_435 at #484: I97 I 558057_260_435 at #485: F98 558057_260_435 at #485: F98 F 558057_260_435 at #486 558057_260_435 at #486 - 558057_260_435 at #487 558057_260_435 at #487 - 558057_260_435 at #530 558057_260_435 at #530 - 558057_260_435 at #532 558057_260_435 at #532 - 558057_260_435 at #533: R99 558057_260_435 at #533: R99 R 558057_260_435 at #534: R100 558057_260_435 at #534: R100 R 558057_260_435 at #535: Q101 558057_260_435 at #535: Q101 Q 558057_260_435 at #544: D102 558057_260_435 at #544: D102 D 558057_260_435 at #545: A103 558057_260_435 at #545: A103 A 558057_260_435 at #548: R104 558057_260_435 at #548: R104 R 558057_260_435 at #549: V105 558057_260_435 at #549: V105 V 558057_260_435 at #550: V106 558057_260_435 at #550: V106 V 558057_260_435 at #551: A107 558057_260_435 at #551: A107 A 558057_260_435 at #552: G108 558057_260_435 at #552: G108 G 558057_260_435 at #553: E109 558057_260_435 at #553: E109 E 558057_260_435 at #554: P110 558057_260_435 at #554: P110 P 558057_260_435 at #555: K111 558057_260_435 at #555: K111 K 558057_260_435 at #556: R112 558057_260_435 at #556: R112 R 558057_260_435 at #557: W113 558057_260_435 at #557: W113 W 558057_260_435 at #558: N114 558057_260_435 at #558: N114 N 558057_260_435 at #559: S115 558057_260_435 at #559: S115 S 558057_260_435 at #560: I116 558057_260_435 at #560: I116 I 558057_260_435 at #561: L117 558057_260_435 at #561: L117 L 558057_260_435 at #562: L118 558057_260_435 at #562: L118 L 558057_260_435 at #565: V119 558057_260_435 at #565: V119 V 558057_260_435 at #566: A120 558057_260_435 at #566: A120 A 558057_260_435 at #568: E121 558057_260_435 at #568: E121 E 558057_260_435 at #570: G122 558057_260_435 at #570: G122 G 558057_260_435 at #571: N123 558057_260_435 at #571: N123 N 558057_260_435 at #572: H124 558057_260_435 at #572: H124 H 558057_260_435 at #588: F125 558057_260_435 at #588: F125 F 558057_260_435 at #589: A126 558057_260_435 at #589: A126 A 558057_260_435 at #592: T127 558057_260_435 at #592: T127 T 558057_260_435 at #594: W128 558057_260_435 at #594: W128 W 558057_260_435 at #595: V129 558057_260_435 at #595: V129 V 558057_260_435 at #596: N130 558057_260_435 at #596: N130 N 558057_260_435 at #598: G131 558057_260_435 at #598: G131 G 558057_260_435 at #599: L132 558057_260_435 at #599: L132 L 558057_260_435 at #600: Q133 558057_260_435 at #600: Q133 Q 558057_260_435 at #601: V134 558057_260_435 at #601: V134 V 558057_260_435 at #602: T135 558057_260_435 at #602: T135 T 558057_260_435 at #603: D136 558057_260_435 at #603: D136 D 558057_260_435 at #604: I137 558057_260_435 at #604: I137 I 558057_260_435 at #605: V138 558057_260_435 at #605: V138 V 558057_260_435 at #606: D139 558057_260_435 at #606: D139 D 558057_260_435 at #607: T140 558057_260_435 at #607: T140 T 558057_260_435 at #608: R141 558057_260_435 at #608: R141 R 558057_260_435 at #609: K142 558057_260_435 at #609: K142 K 558057_260_435 at #610: A143 558057_260_435 at #610: A143 A 558057_260_435 at #611: D144 558057_260_435 at #611: D144 D 558057_260_435 at #612: E145 558057_260_435 at #612: E145 E 558057_260_435 at #613: N146 558057_260_435 at #613: N146 N 558057_260_435 at #614: P147 558057_260_435 at #614: P147 P 558057_260_435 at #615: R148 558057_260_435 at #615: R148 R 558057_260_435 at #616: R149 558057_260_435 at #616: R149 R 558057_260_435 at #640: L151 558057_260_435 at #640: L151 L 558057_260_435 at #641: R152 558057_260_435 at #641: R152 R 558057_260_435 at #642: L153 558057_260_435 at #642: L153 L 558057_260_435 at #643: E154 558057_260_435 at #643: E154 E 558057_260_435 at #644: P155 558057_260_435 at #644: P155 P 558057_260_435 at #645: G156 558057_260_435 at #645: G156 G 558057_260_435 at #646: S157 558057_260_435 at #646: S157 S 558057_260_435 at #647: I158 558057_260_435 at #647: I158 I 558057_260_435 at #648: I159 558057_260_435 at #648: I159 I 558057_260_435 at #649: V160 558057_260_435 at #649: V160 V 558057_260_435 at #650: Q161 558057_260_435 at #650: Q161 Q 558057_260_435 at #653: G162 558057_260_435 at #653: G162 G 558057_260_435 at #654: H163 558057_260_435 at #654: H163 H 558057_260_435 at #655: D164 558057_260_435 at #655: D164 D 558057_260_435 at #668: K165 558057_260_435 at #668: K165 K 558057_260_435 at #689: T166 558057_260_435 at #689: T166 T 558057_260_435 at #690: T167 558057_260_435 at #690: T167 T 558057_260_435 at #691: Q168 558057_260_435 at #691: Q168 Q 558057_260_435 at #694: Y171 558057_260_435 at #694: Y171 Y 558057_260_435 at #695: R172 558057_260_435 at #695: R172 R 558057_260_435 at #696: Q173 558057_260_435 at #696: Q173 Q 558057_260_435 at #697: I174 558057_260_435 at #697: I174 I 558057_260_435 at #698: A175 558057_260_435 at #698: A175 A 558057_260_435 at #699 558057_260_435 at #699 - 558057_260_435 at #700 558057_260_435 at #700 - tandem domain, from Pirellula staleyi DSM 6068 10307912_359_538 tandem domain, from Pirellula staleyi DSM 6068 10307912_359_538 at #155 10307912_359_538 at #155 - 10307912_359_538 at #156 10307912_359_538 at #156 - 10307912_359_538 at #157 10307912_359_538 at #157 - 10307912_359_538 at #158 10307912_359_538 at #158 - 10307912_359_538 at #159: I2 10307912_359_538 at #159: I2 I 10307912_359_538 at #160: F3 10307912_359_538 at #160: F3 F 10307912_359_538 at #162: N4 10307912_359_538 at #162: N4 N 10307912_359_538 at #164: G5 10307912_359_538 at #164: G5 G 10307912_359_538 at #165: K6 10307912_359_538 at #165: K6 K 10307912_359_538 at #168: D7 10307912_359_538 at #168: D7 D 10307912_359_538 at #169: L8 10307912_359_538 at #169: L8 L 10307912_359_538 at #171: T9 10307912_359_538 at #171: T9 T 10307912_359_538 at #172: G10 10307912_359_538 at #172: G10 G 10307912_359_538 at #180: W11 10307912_359_538 at #180: W11 W 10307912_359_538 at #181: S12 10307912_359_538 at #181: S12 S 10307912_359_538 at #185: Q13 10307912_359_538 at #185: Q13 Q 10307912_359_538 at #186: P14 10307912_359_538 at #186: P14 P 10307912_359_538 at #187: E15 10307912_359_538 at #187: E15 E 10307912_359_538 at #188: G16 10307912_359_538 at #188: G16 G 10307912_359_538 at #189: S17 10307912_359_538 at #189: S17 S 10307912_359_538 at #190: K18 10307912_359_538 at #190: K18 K 10307912_359_538 at #191: S19 10307912_359_538 at #191: S19 S 10307912_359_538 at #195: E20 10307912_359_538 at #195: E20 E 10307912_359_538 at #196 10307912_359_538 at #196 - 10307912_359_538 at #197: F21 10307912_359_538 at #197: F21 F 10307912_359_538 at #198: S22 10307912_359_538 at #198: S22 S 10307912_359_538 at #235: V23 10307912_359_538 at #235: V23 V 10307912_359_538 at #236: S24 10307912_359_538 at #236: S24 S 10307912_359_538 at #237: E25 10307912_359_538 at #237: E25 E 10307912_359_538 at #238: D26 10307912_359_538 at #238: D26 D 10307912_359_538 at #240: G27 10307912_359_538 at #240: G27 G 10307912_359_538 at #268: L28 10307912_359_538 at #268: L28 L 10307912_359_538 at #269: L29 10307912_359_538 at #269: L29 L 10307912_359_538 at #270: K30 10307912_359_538 at #270: K30 K 10307912_359_538 at #294 10307912_359_538 at #294 - 10307912_359_538 at #295 10307912_359_538 at #295 - 10307912_359_538 at #296: V31 10307912_359_538 at #296: V31 V 10307912_359_538 at #297: K32 10307912_359_538 at #297: K32 K 10307912_359_538 at #298: N33 10307912_359_538 at #298: N33 N 10307912_359_538 at #299: G34 10307912_359_538 at #299: G34 G 10307912_359_538 at #300: R35 10307912_359_538 at #300: R35 R 10307912_359_538 at #301: G36 10307912_359_538 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10307912_359_538 at #700 10307912_359_538 at #700 - download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory