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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4591527_43_215: single domain, from Planctomyces maris DSM 8797 (has NEQ) 2223153_25_190: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 4908135_36_246: single domain, from Gemmata obscuriglobus UQM 2246 (has NEQ) 554351_85_257: single domain, from Pirellula sp. 1 (has NEQ) 11269824_44_215: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 4591527_43_215 has N60 EQ 2223153_25_190 has N62 EQ 4908135_36_246 has N97 EQ 554351_85_257 has N63 EQ 11269824_44_215 has N68 EQ 4591527_43_215 and 4 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 4591527_43_215 has N E80 Q 2223153_25_190 has N E80 Q 4908135_36_246 has N E115 Q 554351_85_257 has N E81 Q 11269824_44_215 has N E86 Q 4591527_43_215 and 4 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 4591527_43_215 has NE Q82 2223153_25_190 has NE Q82 4908135_36_246 has NE Q117 554351_85_257 has NE Q83 11269824_44_215 has NE Q88 4591527_43_215 and 4 similar proteins have Q aligning to 166Q 4591527_43_215: single domain, from Planctomyces maris DSM 8797 4591527_43_2154591527_43_215: single domain, from Planctomyces maris DSM 8797 0.993 2223153_25_190: single domain, from Solibacter usitatus Ellin6076 2223153_25_1902223153_25_190: single domain, from Solibacter usitatus Ellin6076 0.910 4908135_36_246: single domain, from Gemmata obscuriglobus UQM 2246 4908135_36_2464908135_36_246: single domain, from Gemmata obscuriglobus UQM 2246 0.878 554351_85_257: single domain, from Pirellula sp. 1 554351_85_257554351_85_257: single domain, from Pirellula sp. 1 11269824_44_215: single domain, from Isosphaera pallida IS1B, ATCC 43644 11269824_44_21511269824_44_215: single domain, from Isosphaera pallida IS1B, ATCC 43644 4591527_43_215: single domain, from Planctomyces maris DSM 8797 (has NEQ)4591527_43_215 single domain, from Planctomyces maris DSM 8797 2223153_25_190: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2223153_25_190 single domain, from Solibacter usitatus Ellin6076 4908135_36_246: single domain, from Gemmata obscuriglobus UQM 2246 (has NEQ)4908135_36_246 single domain, from Gemmata obscuriglobus UQM 2246 554351_85_257: single domain, from Pirellula sp. 1 (has NEQ)554351_85_257 single domain, from Pirellula sp. 1 11269824_44_215: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NEQ)11269824_44_215 single domain, from Isosphaera pallida IS1B, ATCC 43644 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory