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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6253341_25_206: single domain, from Chthoniobacter flavus Ellin428 (has NEQ) 2764129_27_207: single domain, from Blastopirellula marina DSM 3645 (has NEQ) 6004371_23_210: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 6253341_25_206 has N66 EQ 2764129_27_207 has N64 EQ 6004371_23_210 has N67 EQ 6253341_25_206 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 6253341_25_206 has N E86 Q 2764129_27_207 has N E84 Q 6004371_23_210 has N E87 Q 6253341_25_206 and 2 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 6253341_25_206 has NE Q88 2764129_27_207 has NE Q86 6004371_23_210 has NE Q89 6253341_25_206 and 2 similar proteins have Q aligning to 166Q 6253341_25_206: single domain, from Chthoniobacter flavus Ellin428 6253341_25_2066253341_25_206: single domain, from Chthoniobacter flavus Ellin428 0.905 2764129_27_207: single domain, from Blastopirellula marina DSM 3645 2764129_27_2072764129_27_207: single domain, from Blastopirellula marina DSM 3645 6004371_23_210: single domain, from Verrucomicrobium spinosum DSM 4136 6004371_23_2106004371_23_210: single domain, from Verrucomicrobium spinosum DSM 4136 6253341_25_206: single domain, from Chthoniobacter flavus Ellin428 (has NEQ)6253341_25_206 single domain, from Chthoniobacter flavus Ellin428 2764129_27_207: single domain, from Blastopirellula marina DSM 3645 (has NEQ)2764129_27_207 single domain, from Blastopirellula marina DSM 3645 6004371_23_210: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ)6004371_23_210 single domain, from Verrucomicrobium spinosum DSM 4136 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory